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2020 24
2021 30
2022 8
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Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.
WHO Solidarity Trial Consortium, Pan H, Peto R, Henao-Restrepo AM, Preziosi MP, Sathiyamoorthy V, Abdool Karim Q, Alejandria MM, Hernández García C, Kieny MP, Malekzadeh R, Murthy S, Reddy KS, Roses Periago M, Abi Hanna P, Ader F, Al-Bader AM, Alhasawi A, Allum E, Alotaibi A, Alvarez-Moreno CA, Appadoo S, Asiri A, Aukrust P, Barratt-Due A, Bellani S, Branca M, Cappel-Porter HBC, Cerrato N, Chow TS, Como N, Eustace J, García PJ, Godbole S, Gotuzzo E, Griskevicius L, Hamra R, Hassan M, Hassany M, Hutton D, Irmansyah I, Jancoriene L, Kirwan J, Kumar S, Lennon P, Lopardo G, Lydon P, Magrini N, Maguire T, Manevska S, Manuel O, McGinty S, Medina MT, Mesa Rubio ML, Miranda-Montoya MC, Nel J, Nunes EP, Perola M, Portolés A, Rasmin MR, Raza A, Rees H, Reges PPS, Rogers CA, Salami K, Salvadori MI, Sinani N, Sterne JAC, Stevanovikj M, Tacconelli E, Tikkinen KAO, Trelle S, Zaid H, Røttingen JA, Swaminathan S. WHO Solidarity Trial Consortium, et al. N Engl J Med. 2021 Feb 11;384(6):497-511. doi: 10.1056/NEJMoa2023184. Epub 2020 Dec 2. N Engl J Med. 2021. PMID: 33264556 Free PMC article. Clinical Trial.
BACKGROUND: World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a - in patients hospitalized with coronavirus disease 2019 ( …
BACKGROUND: World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - r …
Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.
GBD 2019 Stroke Collaborators. GBD 2019 Stroke Collaborators. Lancet Neurol. 2021 Oct;20(10):795-820. doi: 10.1016/S1474-4422(21)00252-0. Epub 2021 Sep 3. Lancet Neurol. 2021. PMID: 34487721 Free PMC article.
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. METHODS: We applied GBD 2019 analytical tools to calculate stroke incidence, …
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these …
Ivermectin for Prophylaxis and Treatment of COVID-19: A Systematic Review and Meta-Analysis.
Cruciani M, Pati I, Masiello F, Malena M, Pupella S, De Angelis V. Cruciani M, et al. Diagnostics (Basel). 2021 Sep 8;11(9):1645. doi: 10.3390/diagnostics11091645. Diagnostics (Basel). 2021. PMID: 34573986 Free PMC article. Review.
OBJECTIVES: We undertook a new systematic review of ivermectin for the treatment and prophylaxis of COVID-19, including new primary studies, outcomes other than mortality, and grading the quality of the available evidence following the Cochrane guidance for m …
OBJECTIVES: We undertook a new systematic review of ivermectin for the treatment and prophylaxis of COVID-19, including new pr …
Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis.
Vai B, Mazza MG, Delli Colli C, Foiselle M, Allen B, Benedetti F, Borsini A, Casanova Dias M, Tamouza R, Leboyer M, Benros ME, Branchi I, Fusar-Poli P, De Picker LJ. Vai B, et al. Lancet Psychiatry. 2021 Sep;8(9):797-812. doi: 10.1016/S2215-0366(21)00232-7. Epub 2021 Jul 17. Lancet Psychiatry. 2021. PMID: 34274033 Free PMC article.
Nine studies provided data on patient race and ethnicity, and 22 studies were rated as high quality. The presence of any mental disorder was associated with an increased risk of COVID-19 mortality (OR 2.00 [95% CI 1.58-2.54]; I(2)= …
Nine studies provided data on patient race and ethnicity, and 22 studies were rated as high quality. The presence of any mental disor …
Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19-A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium.
Chou SH, Beghi E, Helbok R, Moro E, Sampson J, Altamirano V, Mainali S, Bassetti C, Suarez JI, McNett M; GCS-NeuroCOVID Consortium and ENERGY Consortium. Chou SH, et al. JAMA Netw Open. 2021 May 3;4(5):e2112131. doi: 10.1001/jamanetworkopen.2021.12131. JAMA Netw Open. 2021. PMID: 33974053 Free PMC article.
Three cohorts were included: (1) the GCS-NeuroCOVID all COVID-19 cohort (n = 3055), which included consecutive hospitalized patients with COVID-19 with and without neurological manifestations; (2) the GCS-NeuroCOVID COVID-19 neurol …
Three cohorts were included: (1) the GCS-NeuroCOVID all COVID-19 cohort (n = 3055), which included consecutive hospitalized pa …
Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019.
GBD 2019 Under-5 Mortality Collaborators. GBD 2019 Under-5 Mortality Collaborators. Lancet. 2021 Sep 4;398(10303):870-905. doi: 10.1016/S0140-6736(21)01207-1. Epub 2021 Aug 17. Lancet. 2021. PMID: 34416195 Free PMC article.
To understand current rates, recent trends, and potential trajectories of child mortality for the next decade, we present the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 findings for all-cause mortality and cause-specific mortali
To understand current rates, recent trends, and potential trajectories of child mortality for the next decade, we present the Global …
Immune Therapy, or Antiviral Therapy, or Both for COVID-19: A Systematic Review.
Cantini F, Goletti D, Petrone L, Najafi Fard S, Niccoli L, Foti R. Cantini F, et al. Drugs. 2020 Dec;80(18):1929-1946. doi: 10.1007/s40265-020-01421-w. Drugs. 2020. PMID: 33068263 Free PMC article.
BACKGROUND: Based on current evidence, recent guidelines of the National Institute of Health, USA indicated the use of remdesivir and dexamethasone for the treatment of COVID-19 patients with mild-moderate disease, not requiring high-flow oxygen …
BACKGROUND: Based on current evidence, recent guidelines of the National Institute of Health, USA indicated the use of …
Prolonged Low-Dose Methylprednisolone in Patients With Severe COVID-19 Pneumonia.
Salton F, Confalonieri P, Meduri GU, Santus P, Harari S, Scala R, Lanini S, Vertui V, Oggionni T, Caminati A, Patruno V, Tamburrini M, Scartabellati A, Parati M, Villani M, Radovanovic D, Tomassetti S, Ravaglia C, Poletti V, Vianello A, Gaccione AT, Guidelli L, Raccanelli R, Lucernoni P, Lacedonia D, Foschino Barbaro MP, Centanni S, Mondoni M, Davì M, Fantin A, Cao X, Torelli L, Zucchetto A, Montico M, Casarin A, Romagnoli M, Gasparini S, Bonifazi M, D'Agaro P, Marcello A, Licastro D, Ruaro B, Volpe MC, Umberger R, Confalonieri M. Salton F, et al. Open Forum Infect Dis. 2020 Sep 12;7(10):ofaa421. doi: 10.1093/ofid/ofaa421. eCollection 2020 Oct. Open Forum Infect Dis. 2020. PMID: 33072814 Free PMC article.
BACKGROUND: In hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia, progression to acute respiratory failure requiring invasive mechanical ventilation (MV) is associated with significant morbidity and mortality
BACKGROUND: In hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia, progression to acute
Maternal and Infant Outcomes Associated with Maternity Practices Related to COVID-19: The COVID Mothers Study.
Bartick MC, Valdés V, Giusti A, Chapin EM, Bhana NB, Hernández-Aguilar MT, Duarte ED, Jenkins L, Gaughan J, Feldman-Winter L. Bartick MC, et al. Breastfeed Med. 2021 Mar;16(3):189-199. doi: 10.1089/bfm.2020.0353. Epub 2021 Feb 9. Breastfeed Med. 2021. PMID: 33565900
Using multivariable logistic regression, Fisher's exact test, and summary statistics, we assessed the association of skin-to-skin care, feeding, and rooming-in with SARS-CoV-2 outcomes, breastfeeding outcomes, and maternal distress. Results: Responses …
Using multivariable logistic regression, Fisher's exact test, and summary statistics, we assessed the association of skin-to-skin car …
The global impact of SARS-CoV-2 in 181 people with cystic fibrosis.
McClenaghan E, Cosgriff R, Brownlee K, Ahern S, Burgel PR, Byrnes CA, Colombo C, Corvol H, Cheng SY, Daneau G, Elbert A, Faro A, Goss CH, Gulmans V, Gutierrez H, de Monestrol I, Jung A, Justus LN, Kashirskaya N, Marshall BC, McKone E, Middleton PG, Mondejar-Lopez P, Pastor-Vivero MD, Padoan R, Rizvi S, Ruseckaite R, Salvatore M, Stephenson AL, Filho LVRDS, Melo J, Zampoli M, Carr SB; Global Registry Harmonization Group. McClenaghan E, et al. J Cyst Fibros. 2020 Nov;19(6):868-871. doi: 10.1016/j.jcf.2020.10.003. Epub 2020 Nov 4. J Cyst Fibros. 2020. PMID: 33183965 Free PMC article.
With the growing SARS-CoV-2 pandemic, we need to better understand its impact in specific patient groups like those with Cystic Fibrosis (CF). We report on 181 people with CF (32 post-transplant) from 19 countries diagnosed with SARS-C
With the growing SARS-CoV-2 pandemic, we need to better understand its impact in specific patient groups like th …
55 results