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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2013 4
2014 5
2015 8
2016 11
2017 8
2018 6
2019 11
2020 4
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50 results
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Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.
Krajnc A, Brem J, Hinchliffe P, Calvopiña K, Panduwawala TD, Lang PA, Kamps JJAG, Tyrrell JM, Widlake E, Saward BG, Walsh TR, Spencer J, Schofield CJ. Krajnc A, et al. Among authors: brem j. J Med Chem. 2019 Sep 26;62(18):8544-8556. doi: 10.1021/acs.jmedchem.9b00911. Epub 2019 Sep 16. J Med Chem. 2019. PMID: 31454231 Free PMC article.
Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.
Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough MA, Dhir S, Proudfoot NJ, Schofield CJ. Pettinati I, et al. Among authors: brem j. Elife. 2018 Dec 3;7:e39865. doi: 10.7554/eLife.39865. Elife. 2018. PMID: 30507380 Free PMC article.
Molecular Basis of Class A β-Lactamase Inhibition by Relebactam.
Tooke CL, Hinchliffe P, Lang PA, Mulholland AJ, Brem J, Schofield CJ, Spencer J. Tooke CL, et al. Among authors: brem j. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00564-19. doi: 10.1128/AAC.00564-19. Print 2019 Oct. Antimicrob Agents Chemother. 2019. PMID: 31383664 Free PMC article.
Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation.
Lohans CT, Freeman EI, Groesen EV, Tooke CL, Hinchliffe P, Spencer J, Brem J, Schofield CJ. Lohans CT, et al. Among authors: brem j. Sci Rep. 2019 Sep 20;9(1):13608. doi: 10.1038/s41598-019-49264-0. Sci Rep. 2019. PMID: 31541180 Free PMC article.
Will morphing boron-based inhibitors beat the β-lactamases?
Krajnc A, Lang PA, Panduwawala TD, Brem J, Schofield CJ. Krajnc A, et al. Among authors: brem j. Curr Opin Chem Biol. 2019 Jun;50:101-110. doi: 10.1016/j.cbpa.2019.03.001. Epub 2019 Apr 18. Curr Opin Chem Biol. 2019. PMID: 31004962 Free PMC article. Review.
Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis.
Abboud MI, Kosmopoulou M, Krismanich AP, Johnson JW, Hinchliffe P, Brem J, Claridge TDW, Spencer J, Schofield CJ, Dmitrienko GI. Abboud MI, et al. Among authors: brem j. Chemistry. 2018 Apr 17;24(22):5734-5737. doi: 10.1002/chem.201705886. Epub 2018 Jan 17. Chemistry. 2018. PMID: 29250863 Free PMC article.
Profiling interactions of vaborbactam with metallo-β-lactamases.
Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J. Langley GW, et al. Among authors: brem j. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17. Bioorg Med Chem Lett. 2019. PMID: 31171422 Free PMC article.
The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins.
Pettinati I, Brem J, Lee SY, McHugh PJ, Schofield CJ. Pettinati I, et al. Among authors: brem j. Trends Biochem Sci. 2016 Apr;41(4):338-355. doi: 10.1016/j.tibs.2015.12.007. Epub 2016 Jan 21. Trends Biochem Sci. 2016. PMID: 26805042 Free PMC article. Review.
A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation.
Lohans CT, van Groesen E, Kumar K, Tooke CL, Spencer J, Paton RS, Brem J, Schofield CJ. Lohans CT, et al. Among authors: brem j. Angew Chem Int Ed Engl. 2018 Jan 26;57(5):1282-1285. doi: 10.1002/anie.201711308. Epub 2018 Jan 5. Angew Chem Int Ed Engl. 2018. PMID: 29236332 Free PMC article.
Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.
Zhang D, Markoulides MS, Stepanovs D, Rydzik AM, El-Hussein A, Bon C, Kamps JJAG, Umland KD, Collins PM, Cahill ST, Wang DY, von Delft F, Brem J, McDonough MA, Schofield CJ. Zhang D, et al. Among authors: brem j. Bioorg Med Chem. 2018 Jul 15;26(11):2928-2936. doi: 10.1016/j.bmc.2018.02.043. Epub 2018 Feb 23. Bioorg Med Chem. 2018. PMID: 29655609 Free PMC article.
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