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A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer.
Ott PA, Hu-Lieskovan S, Chmielowski B, Govindan R, Naing A, Bhardwaj N, Margolin K, Awad MM, Hellmann MD, Lin JJ, Friedlander T, Bushway ME, Balogh KN, Sciuto TE, Kohler V, Turnbull SJ, Besada R, Curran RR, Trapp B, Scherer J, Poran A, Harjanto D, Barthelme D, Ting YS, Dong JZ, Ware Y, Huang Y, Huang Z, Wanamaker A, Cleary LD, Moles MA, Manson K, Greshock J, Khondker ZS, Fritsch E, Rooney MS, DeMario M, Gaynor RB, Srinivasan L. Ott PA, et al. Cell. 2020 Oct 15;183(2):347-362.e24. doi: 10.1016/j.cell.2020.08.053. Cell. 2020. PMID: 33064988 Free article. Clinical Trial.
Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma.
Hu Z, Leet DE, Allesøe RL, Oliveira G, Li S, Luoma AM, Liu J, Forman J, Huang T, Iorgulescu JB, Holden R, Sarkizova S, Gohil SH, Redd RA, Sun J, Elagina L, Giobbie-Hurder A, Zhang W, Peter L, Ciantra Z, Rodig S, Olive O, Shetty K, Pyrdol J, Uduman M, Lee PC, Bachireddy P, Buchbinder EI, Yoon CH, Neuberg D, Pentelute BL, Hacohen N, Livak KJ, Shukla SA, Olsen LR, Barouch DH, Wucherpfennig KW, Fritsch EF, Keskin DB, Wu CJ, Ott PA. Hu Z, et al. Nat Med. 2021 Mar;27(3):515-525. doi: 10.1038/s41591-020-01206-4. Epub 2021 Jan 21. Nat Med. 2021. PMID: 33479501 Free PMC article.
Natural History of the Dysplastic Hip Following Modern Periacetabular Osteotomy.
Wyles CC, Vargas JS, Heidenreich MJ, Mara KC, Peters CL, Clohisy JC, Trousdale RT, Sierra RJ. Wyles CC, et al. J Bone Joint Surg Am. 2019 May 15;101(10):932-938. doi: 10.2106/JBJS.18.00983. J Bone Joint Surg Am. 2019. PMID: 31094985 Clinical Trial.
The purpose of this multicenter cohort study was to delineate the long-term radiographic natural history of the dysplastic hip following PAO. METHODS: We evaluated all patients undergoing PAO from 1996 to 2012 at 3 academic institutions in the United States. Inclusi …
The purpose of this multicenter cohort study was to delineate the long-term radiographic natural history of the dysplastic hip following …
Machine learning based algorithms to impute PaO2 from SpO2 values and development of an online calculator.
Ren S, Zupetic JA, Tabary M, DeSensi R, Nouraie M, Lu X, Boyce RD, Lee JS. Ren S, et al. Sci Rep. 2022 May 17;12(1):8235. doi: 10.1038/s41598-022-12419-7. Sci Rep. 2022. PMID: 35581469 Free PMC article.
We created an online calculator using machine learning (ML) algorithms to impute the partial pressure of oxygen (PaO(2))/fraction of delivered oxygen (FiO(2)) ratio using the non-invasive peripheral saturation of oxygen (SpO(2)) and compared the accuracy of the ML models w …
We created an online calculator using machine learning (ML) algorithms to impute the partial pressure of oxygen (PaO(2))/fraction of …
Unaddressed Cam Deformity Is Associated with Elevated Joint Contact Stress After Periacetabular Osteotomy.
Scott EJ, Thomas-Aitken HD, Glass N, Westermann R, Goetz JE, Willey MC. Scott EJ, et al. J Bone Joint Surg Am. 2018 Oct 17;100(20):e131. doi: 10.2106/JBJS.17.01631. J Bone Joint Surg Am. 2018. PMID: 30334890
Our purpose was to identify the relationship between cam deformity and joint contact stress after periacetabular osteotomy (PAO). We hypothesized that cam deformity is associated with an increase in peak joint contact stress after PAO. ...Radiographic measures of ac …
Our purpose was to identify the relationship between cam deformity and joint contact stress after periacetabular osteotomy (PAO). We …
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.
Pao PC, Seo J, Lee A, Kritskiy O, Patnaik D, Penney J, Raju RM, Geigenmuller U, Silva MC, Lucente DE, Gusella JF, Dickerson BC, Loon A, Yu MX, Bula M, Yu M, Haggarty SJ, Tsai LH. Pao PC, et al. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2217864120. doi: 10.1073/pnas.2217864120. Epub 2023 Apr 12. Proc Natl Acad Sci U S A. 2023. PMID: 37043533
When tagged with a fluorophore (FITC) and the cell-penetrating transactivator of transcription (TAT) sequence, the Cdk5i-FT peptide exhibits cell- and brain-penetrant properties and confers protection against neurodegenerative phenotypes associated with Cdk5 hyperactivity in cell …
When tagged with a fluorophore (FITC) and the cell-penetrating transactivator of transcription (TAT) sequence, the Cdk5i-FT peptide exhibits …
Assessment of Disability Related to Hip Dysplasia Using Objective Measures of Physical Performance.
Scott EJ, Willey MC, Mercado A, Davison J, Wilken JM. Scott EJ, et al. Orthop J Sports Med. 2020 Feb 27;8(2):2325967120903290. doi: 10.1177/2325967120903290. eCollection 2020 Feb. Orthop J Sports Med. 2020. PMID: 33283014 Free PMC article.
PURPOSE: To evaluate 4 different PPMs for their ability to differentiate between young adults with hip dysplasia indicated for treatment with periacetabular osteotomy (PAO) and asymptomatic controls and to test inter- and intratest reliability and relationship with popular …
PURPOSE: To evaluate 4 different PPMs for their ability to differentiate between young adults with hip dysplasia indicated for treatment wit …
Combined TCR Repertoire Profiles and Blood Cell Phenotypes Predict Melanoma Patient Response to Personalized Neoantigen Therapy plus Anti-PD-1.
Poran A, Scherer J, Bushway ME, Besada R, Balogh KN, Wanamaker A, Williams RG, Prabhakara J, Ott PA, Hu-Lieskovan S, Khondker ZS, Gaynor RB, Rooney MS, Srinivasan L. Poran A, et al. Cell Rep Med. 2020 Nov 17;1(8):100141. doi: 10.1016/j.xcrm.2020.100141. eCollection 2020 Nov 17. Cell Rep Med. 2020. PMID: 33294862 Free PMC article. Clinical Trial.
Marginal and internal fit evaluation of conventional metal-ceramic versus zirconia CAD/CAM crowns.
Paul N, Raghavendra Swamy KN, Dhakshaini MR, Sowmya S, Ravi MB. Paul N, et al. J Clin Exp Dent. 2020 Jan 1;12(1):e31-e37. doi: 10.4317/medoral.55946. eCollection 2020 Jan. J Clin Exp Dent. 2020. PMID: 31976041 Free PMC article.
The points measured were PM for marginal gap, PA for axial gap, PAO for axio-occlusal transition gap and PO and PCO for occlusal gaps using a stereomicroscope at 30 magnification. ...
The points measured were PM for marginal gap, PA for axial gap, PAO for axio-occlusal transition gap and PO and PCO for occlusal gaps …
Hitting the Target: Natural History of the Hip Based on Achieving an Acetabular Safe Zone Following Periacetabular Osteotomy.
Wyles CC, Vargas JS, Heidenreich MJ, Mara KC, Peters CL, Clohisy JC, Trousdale RT, Sierra RJ. Wyles CC, et al. J Bone Joint Surg Am. 2020 Oct 7;102(19):1734-1740. doi: 10.2106/JBJS.19.01503. J Bone Joint Surg Am. 2020. PMID: 33027126
BACKGROUND: Periacetabular osteotomy (PAO) remains the gold-standard treatment for acetabular dysplasia in skeletally mature patients with preserved cartilage. The purpose of this multicenter cohort study was to delineate the long-term radiographic natural history of the d …
BACKGROUND: Periacetabular osteotomy (PAO) remains the gold-standard treatment for acetabular dysplasia in skeletally mature patients …
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