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Identification of Deubiquitinase Substrates in Saccharomyces cerevisiae by Systematic Overexpression.
Arsenault HE, Benanti JA. Arsenault HE, et al. Methods Mol Biol. 2023;2591:237-253. doi: 10.1007/978-1-0716-2803-4_14. Methods Mol Biol. 2023. PMID: 36350552
A significant hurdle to understanding the functions of deubiquitinases (DUBs) is the identification of their in vivo substrates. ...
A significant hurdle to understanding the functions of deubiquitinases (DUBs) is the identification of their in vivo substrates. ...
In Vitro-In Vivo Extrapolation of Key Transporter Activity at the Blood-Brain Barrier.
Trapa PE, Troutman MD, Lau TY, Wager TT, Maurer TS, Patel NC, West MA, Umland JP, Carlo AA, Feng B, Liras JL. Trapa PE, et al. Drug Metab Dispos. 2019 Apr;47(4):405-411. doi: 10.1124/dmd.118.083279. Epub 2019 Jan 25. Drug Metab Dispos. 2019. PMID: 30683809
Understanding the quantitative implications of P-glycoprotein and breast cancer resistance protein efflux is a key hurdle in the design of effective, centrally acting or centrally restricted therapeutics. ...
Understanding the quantitative implications of P-glycoprotein and breast cancer resistance protein efflux is a key hurdle in the desi …
Survivor and patient advocate: an interview with T.J. Sharpe.
J Sharpe T. J Sharpe T. Melanoma Manag. 2017 Sep;4(3):157-160. doi: 10.2217/mmt-2017-0012. Epub 2017 Jul 31. Melanoma Manag. 2017. PMID: 30190920 Free PMC article.
His story is about life with a serious illness, and the mental and emotional hurdles a patient must clear. He writes how a cancer patient's challenges mirror those many face, and portrays life through the optimistic prism of a patient who is on the long, winding road towar …
His story is about life with a serious illness, and the mental and emotional hurdles a patient must clear. He writes how a cancer pat …
Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni.
Lombardo FC, Pasche V, Panic G, Endriss Y, Keiser J. Lombardo FC, et al. Nat Protoc. 2019 Feb;14(2):461-481. doi: 10.1038/s41596-018-0101-y. Nat Protoc. 2019. PMID: 30610241
Whereas numerous different protocols to obtain and cultivate schistosomes have been published, those describing the drug-screening process are scarce, and none gather together parasite cultivation and early drug discovery procedures. To help overcome this hurdle, we provid …
Whereas numerous different protocols to obtain and cultivate schistosomes have been published, those describing the drug-screening process a …
The European Union's Adequacy Approach to Privacy and International Data Sharing in Health Research.
Stoddart J, Chan B, Joly Y. Stoddart J, et al. J Law Med Ethics. 2016 Mar;44(1):143-55. doi: 10.1177/1073110516644205. J Law Med Ethics. 2016. PMID: 27256130
In practice, the inconsistency with which these evaluations are made presents a hurdle to international data-sharing and makes difficult the integration of different data-sharing approaches; in the 20 years since the Directive was first adopted, the laws of only five count …
In practice, the inconsistency with which these evaluations are made presents a hurdle to international data-sharing and makes diffic …
Study protocol: Community Links to Establish Alcohol Recovery (CLEAR) for women leaving jail.
Johnson JE, Schonbrun YC, Anderson B, Kurth M, Timko C, Stein M. Johnson JE, et al. Contemp Clin Trials. 2017 Apr;55:39-46. doi: 10.1016/j.cct.2017.02.001. Epub 2017 Feb 7. Contemp Clin Trials. 2017. PMID: 28185995 Free PMC article. Clinical Trial.
We hypothesize that (Minton, 2015) 12-step involvement will mediate the intervention's effect on alcohol use, and (O'Brien, 2001) percent days abstinent will mediate the intervention's effect on STI/HIV risk-taking outcomes. Research methods accommodate logistical and philosophic …
We hypothesize that (Minton, 2015) 12-step involvement will mediate the intervention's effect on alcohol use, and (O'Brien, 2001) percent da …
Taking Action on Air Pollution Control in the Beijing-Tianjin-Hebei (BTH) Region: Progress, Challenges and Opportunities.
Wang L, Zhang F, Pilot E, Yu J, Nie C, Holdaway J, Yang L, Li Y, Wang W, Vardoulakis S, Krafft T. Wang L, et al. Int J Environ Res Public Health. 2018 Feb 9;15(2):306. doi: 10.3390/ijerph15020306. Int J Environ Res Public Health. 2018. PMID: 29425189 Free PMC article.
Further suggestions were provided to improve the conceptual design and effective implementation of respective air pollution control strategies in BTH. Our study highlights some of the major hurdles that need to be addressed to succeed with a comprehensive air pollution con …
Further suggestions were provided to improve the conceptual design and effective implementation of respective air pollution control strategi …
Bridging science and traditional knowledge to assess cumulative impacts of stressors on ecosystem health.
Mantyka-Pringle CS, Jardine TD, Bradford L, Bharadwaj L, Kythreotis AP, Fresque-Baxter J, Kelly E, Somers G, Doig LE, Jones PD, Lindenschmidt KE; Slave River and Delta Partnership. Mantyka-Pringle CS, et al. Environ Int. 2017 May;102:125-137. doi: 10.1016/j.envint.2017.02.008. Epub 2017 Feb 27. Environ Int. 2017. PMID: 28249740
Yet the combined use of Traditional Knowledge (TK) and Scientific Knowledge (SK) has both technical and philosophical hurdles to overcome, and suffers from inherently imbalanced power dynamics that can disfavour the very communities it intends to benefit. ...
Yet the combined use of Traditional Knowledge (TK) and Scientific Knowledge (SK) has both technical and philosophical hurdles to over …
We only talk about breast feeding: a discourse analysis of infant feeding messages in antenatal group-based education.
Jennifer F, Elaine B, Athena S, Virginia S. Jennifer F, et al. Midwifery. 2013 May;29(5):425-33. doi: 10.1016/j.midw.2012.02.006. Epub 2012 Apr 27. Midwifery. 2013. PMID: 22541692
Antenatal commitment to breast feeding was deemed necessary if women were to overcome potential hurdles and maintain a commitment to the supply of breast milk. The latter two discourses, drawn upon to promote the breast-feeding message, presented infants as 'hard wired' to …
Antenatal commitment to breast feeding was deemed necessary if women were to overcome potential hurdles and maintain a commitment to …