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Page 1
Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities.
Zhu H, Li W, Shuai W, Liu Y, Yang L, Tan Y, Zheng T, Yao H, Xu J, Zhu Z, Yang DH, Chen ZS, Xu S. Zhu H, et al. Eur J Med Chem. 2021 Apr 15;216:113316. doi: 10.1016/j.ejmech.2021.113316. Epub 2021 Feb 24. Eur J Med Chem. 2021. PMID: 33676300
Mechanism studies demonstrated that 20b bound to the colchicine binding site and displayed potent anti-vascular activity. ...Collectively, 20b and 20b-P are novel promising anti-tubulin agents with more druggable properties and deserve to be further investiga …
Mechanism studies demonstrated that 20b bound to the colchicine binding site and displayed potent anti-vascular activity. ...Collecti …
Phyto-oxylipin mediated plant immune response to colonization and infection in the soybean-Phytophthora sojae pathosystem.
Adigun OA, Pham TH, Grapov D, Nadeem M, Jewell LE, Cheema M, Galagedara L, Thomas R. Adigun OA, et al. Front Plant Sci. 2023 May 12;14:1141823. doi: 10.3389/fpls.2023.1141823. eCollection 2023. Front Plant Sci. 2023. PMID: 37251755 Free PMC article.
Soybean root and stem rot caused by Phytophthora sojae results in approximately 20B $US crop loss annually. Phyto-oxylipins are metabolites biosynthesized in the plants by oxidative transformation of polyunsaturated fatty acids through an array of diverging metabolic pathw …
Soybean root and stem rot caused by Phytophthora sojae results in approximately 20B $US crop loss annually. Phyto-oxylipins are metab …
Computational Applications in Secondary Metabolite Discovery (CAiSMD): an online workshop.
Ntie-Kang F, Telukunta KK, Fobofou SAT, Chukwudi Osamor V, Egieyeh SA, Valli M, Djoumbou-Feunang Y, Sorokina M, Stork C, Mathai N, Zierep P, Chávez-Hernández AL, Duran-Frigola M, Babiaka SB, Tematio Fouedjou R, Eni DB, Akame S, Arreyetta-Bawak AB, Ebob OT, Metuge JA, Bekono BD, Isa MA, Onuku R, Shadrack DM, Musyoka TM, Patil VM, van der Hooft JJJ, da Silva Bolzani V, Medina-Franco JL, Kirchmair J, Weber T, Tastan Bishop Ö, Medema MH, Wessjohann LA, Ludwig-Müller J. Ntie-Kang F, et al. J Cheminform. 2021 Sep 6;13(1):64. doi: 10.1186/s13321-021-00546-8. J Cheminform. 2021. PMID: 34488889 Free PMC article.
Induction of targeted osteogenesis with 3-aryl-2H-benzopyrans and 3-aryl-3H-benzopyrans: Novel osteogenic agents.
Gupta A, Ahmad I, Kureel J, Hasanain M, Pandey P, Singh S, John AA, Sarkar J, Singh D. Gupta A, et al. J Steroid Biochem Mol Biol. 2016 Apr;158:63-75. doi: 10.1016/j.jsbmb.2016.01.010. Epub 2016 Jan 22. J Steroid Biochem Mol Biol. 2016. PMID: 26807865
The results showed that 20b and 32 significantly increased mineral nodule formation and the transcript levels of BMP-2, RUNX-2 and osteocalcin at 100pM concentrations respectively. Further mechanistic studies of 20b and 32 using transiently knocked down expression o …
The results showed that 20b and 32 significantly increased mineral nodule formation and the transcript levels of BMP-2, RUNX-2 and os …
Lipid mediated plant immunity in susceptible and tolerant soybean cultivars in response to Phytophthora sojae colonization and infection.
Adigun OA, Pham TH, Grapov D, Nadeem M, Jewell LE, Galagedara L, Cheema M, Thomas R. Adigun OA, et al. BMC Plant Biol. 2024 Mar 1;24(1):154. doi: 10.1186/s12870-024-04808-z. BMC Plant Biol. 2024. PMID: 38424489 Free PMC article.
The annual global crop losses due to infection by Phytophthora sojae is currently estimated at $20B USD, yet we have limited understanding of the role of lipid mediators in the adaptative strategies used by the host plant to limit infection. ...
The annual global crop losses due to infection by Phytophthora sojae is currently estimated at $20B USD, yet we have limited understa …
Expression pattern of metallothionein, MTF-1 nuclear translocation, and its dna-binding activity in zebrafish (Danio rerio) induced by zinc and cadmium.
Chen WY, John JA, Lin CH, Chang CY. Chen WY, et al. Environ Toxicol Chem. 2007 Jan;26(1):110-7. doi: 10.1897/06-153r.1. Environ Toxicol Chem. 2007. PMID: 17269467
The MTF-1 protein was produced recombinantly by inserting zebrafish mtf-1 cDNA (1.8 kb) into pET-20b(+) expression vector and expressing in Escherichia coli BL21 (DE3) pLysS host strain competent cell on induction with isopropyl-beta-D-thiogalactopyranoside. ...
The MTF-1 protein was produced recombinantly by inserting zebrafish mtf-1 cDNA (1.8 kb) into pET-20b(+) expression vector and express …
Automated data evaluation and modelling of simultaneous (19) F-(1) H medium-resolution NMR spectra for online reaction monitoring.
Zientek N, Laurain C, Meyer K, Paul A, Engel D, Guthausen G, Kraume M, Maiwald M. Zientek N, et al. Magn Reson Chem. 2016 Jun;54(6):513-20. doi: 10.1002/mrc.4216. Epub 2015 Apr 9. Magn Reson Chem. 2016. PMID: 25854892
Although, superior results are obtained from both IHM and PLS-R for (1) H MR-NMR, especially the latter demands for elaborate data pretreatment, whereas IHM models needed no previous alignment. Copyright 2015 John Wiley & Sons, Ltd....
Although, superior results are obtained from both IHM and PLS-R for (1) H MR-NMR, especially the latter demands for elaborate data pretreatm …
Expression of ayu (Plecoglossus altivelis) Pit-1 in Escherichia coli: its purification and immunohistochemical detection using monoclonal antibody.
Chiu CC, John JA, Hseu TH, Chang CY. Chiu CC, et al. Protein Expr Purif. 2002 Mar;24(2):292-301. doi: 10.1006/prep.2001.1558. Protein Expr Purif. 2002. PMID: 11858725
We inserted the coding region of Pit-1 cDNA, obtained by PCR, into a pET-20b(+) plasmid to produce recombinant Pit-1 in Escherichia coli BL21 (DE3) pLysS cells. ...
We inserted the coding region of Pit-1 cDNA, obtained by PCR, into a pET-20b(+) plasmid to produce recombinant Pit-1 in Escherichia c …