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61 results

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The following terms were not found in PubMed: 20Kimball
Page 1
Updated Review and Perspective on 20S Proteasome Inhibitors in the Treatment of Lung Cancer.
Rohondia SO, Ahmed ZSO, Dou QP. Rohondia SO, et al. Curr Cancer Drug Targets. 2020;20(6):392-409. doi: 10.2174/1568009620666200226094000. Curr Cancer Drug Targets. 2020. PMID: 32101123 Review.
Many combinational therapies of 20S PIs with conventional chemotherapy were shown to be well tolerated in clinical trials. However, there have not been any consistent data showing the beneficial effects of such proteasome inhibitor-based therapies. Low clinical efficacy of …
Many combinational therapies of 20S PIs with conventional chemotherapy were shown to be well tolerated in clinical trials. However, t …
A Sensitive High-Throughput Screening Method for Identifying Small Molecule Stimulators of the Core Particle of the Proteasome.
Coleman RA, Trader DJ. Coleman RA, et al. Curr Protoc Chem Biol. 2018 Dec;10(4):e52. doi: 10.1002/cpch.52. Epub 2018 Oct 4. Curr Protoc Chem Biol. 2018. PMID: 30285317 Free PMC article.
We have recently reported a biochemical assay utilizing a FRET reporter peptide to monitor the activity of the 20S catalytic particle (20S CP) of the proteasome. This assay is designed specifically to have increased sensitivity to identify stimulators of the 20S …
We have recently reported a biochemical assay utilizing a FRET reporter peptide to monitor the activity of the 20S catalytic particle …
Signs heralding appearance of thymomas after extended thymectomy for myasthenia gravis.
Santos E, Silva AM, Stroebel P, Marinho A, Willcox N, Goncalves G, Lopes C, Marx A, Leite MI. Santos E, et al. Neurol Clin Pract. 2019 Feb;9(1):48-52. doi: 10.1212/CPJ.0000000000000551. Neurol Clin Pract. 2019. PMID: 30859007 Free PMC article. Review.
We describe 2 such cases that highlight potential early warning signs. RECENT FINDINGS: In their 20s, one woman and one man developed EOMG (AChR antibody-positive), requiring extended transsternal removal of hyperplastic thymi at ages 35 and 27, respectively. ...
We describe 2 such cases that highlight potential early warning signs. RECENT FINDINGS: In their 20s, one woman and one man developed …
The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain.
Mather M, Harley CW. Mather M, et al. Trends Cogn Sci. 2016 Mar;20(3):214-226. doi: 10.1016/j.tics.2016.01.001. Trends Cogn Sci. 2016. PMID: 26895736 Free PMC article. Review.
The LC is especially vulnerable to toxins and infection and is often the first place Alzheimer's-related pathology appears, with most people showing at least some tau pathology by their mid-20s. On the other hand, NE released from the LC during arousing, mentally challengi …
The LC is especially vulnerable to toxins and infection and is often the first place Alzheimer's-related pathology appears, with most people …
Moyamoya-Like Vasculopathy and Orbital Trauma: An Association.
Alexis JA, Lock J, Kho L, Thompson AL, Prentice DA. Alexis JA, et al. Neuroophthalmology. 2023 May 17;47(5-6):262-268. doi: 10.1080/01658107.2023.2212756. eCollection 2023. Neuroophthalmology. 2023. PMID: 38130810
An Asian man in his 20s developed asymptomatic ipsilateral moyamoya-like vascular changes following orbital and head trauma. ...
An Asian man in his 20s developed asymptomatic ipsilateral moyamoya-like vascular changes following orbital and head trauma. ...
COVID-19 vaccine triggered autoimmune hepatitis: case report.
Mathew M, John SB, Sebastian J, Ravi MD. Mathew M, et al. Eur J Hosp Pharm. 2023 Sep;30(5):e27. doi: 10.1136/ejhpharm-2022-003485. Epub 2022 Oct 7. Eur J Hosp Pharm. 2023. PMID: 36207131 Free PMC article.
AIH may also be potentiated with the use of vaccines: this case reports one such event following immunisation, along with 1 year of follow-up. A female patient in her late 20s presented to the hospital with yellowish discolouration of eyes, urine and stools. ...
AIH may also be potentiated with the use of vaccines: this case reports one such event following immunisation, along with 1 year of follow-u …
The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation.
Wang H, Li B, Asha K, Pangilinan RL, Thuraisamy A, Chopra H, Rokudai S, Yu Y, Prives CL, Zhu Y. Wang H, et al. J Biol Chem. 2021 Nov;297(5):101292. doi: 10.1016/j.jbc.2021.101292. Epub 2021 Oct 8. J Biol Chem. 2021. PMID: 34627839 Free PMC article.
We report here that zinc depletion by the ion chelator TPEN or Chelex resin results in MDMX protein degradation in a ubiquitination-independent and 20S proteasome-dependent manner. Restoration of zinc led to recovery of cellular levels of MDMX. ...
We report here that zinc depletion by the ion chelator TPEN or Chelex resin results in MDMX protein degradation in a ubiquitination-independ …
Tooth Loss and Dementia: A Critical Examination.
Thomson WM, Barak Y. Thomson WM, et al. J Dent Res. 2021 Mar;100(3):226-231. doi: 10.1177/0022034520957233. Epub 2020 Sep 18. J Dent Res. 2021. PMID: 32942945
Their less cognitively able childhood counterparts will experience higher disease rates and poorer access to care, resulting in greater incremental tooth loss. Comparison of the 2 groups at any age from the mid-20s on will show greater numbers of missing teeth in the group …
Their less cognitively able childhood counterparts will experience higher disease rates and poorer access to care, resulting in greater incr …
"I just wanted more": Hereditary cancer syndromes patients' perspectives on the utility of circulating tumour DNA testing for cancer screening.
Adi-Wauran E, Clausen M, Shickh S, Gagliardi AR, Denburg A, Oldfield LE, Sam J, Reble E, Krishnapillai S, Regier DA, Baxter NN, Dawson L, Penney LS, Foulkes W, Basik M, Sun S, Schrader KA, Karsan A, Pollett A, Pugh TJ; CHARM consortium; Kim RH, Bombard Y. Adi-Wauran E, et al. Eur J Hum Genet. 2024 Feb;32(2):176-181. doi: 10.1038/s41431-023-01473-y. Epub 2023 Oct 11. Eur J Hum Genet. 2024. PMID: 37821757
Thirty HCS patients were interviewed (n = 19 women, age range 20s-70s, n = 25 were white). Participants were highly concerned about developing cancers, particularly those without reliable screening options for early detection. ...
Thirty HCS patients were interviewed (n = 19 women, age range 20s-70s, n = 25 were white). Participants were highly concerned about d …
Do Disordered Eating Behaviours Have Long-term Health-related Consequences?
Kärkkäinen U, Mustelin L, Raevuori A, Kaprio J, Keski-Rahkonen A. Kärkkäinen U, et al. Eur Eat Disord Rev. 2018 Jan;26(1):22-28. doi: 10.1002/erv.2568. Epub 2017 Nov 21. Eur Eat Disord Rev. 2018. PMID: 29160017 Free PMC article.
OBJECTIVE: Long-term health-related consequences of disordered eating behaviours of young adults remain poorly understood. We examined whether disordered eating behaviours in mid-20s are associated with physical and mental health 10 years later. ...CONCLUSIONS: Among young …
OBJECTIVE: Long-term health-related consequences of disordered eating behaviours of young adults remain poorly understood. We examined wheth …
61 results