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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 1
2002 8
2003 18
2004 13
2005 16
2006 15
2007 11
2008 24
2009 27
2010 29
2011 22
2012 39
2013 33
2014 35
2015 39
2016 47
2017 38
2018 47
2019 46
2020 62
2021 86
2022 114
2023 115
2024 139
2025 180
2026 39

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1,126 results

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Page 1
Lithocholic acid phenocopies anti-ageing effects of calorie restriction.
Qu Q, Chen Y, Wang Y, Long S, Wang W, Yang HY, Li M, Tian X, Wei X, Liu YH, Xu S, Zhang C, Zhu M, Lam SM, Wu J, Yun C, Chen J, Xue S, Zhang B, Zheng ZZ, Piao HL, Jiang C, Guo H, Shui G, Deng X, Zhang CS, Lin SC. Qu Q, et al. Among authors: chen j. Nature. 2025 Jul;643(8070):192-200. doi: 10.1038/s41586-024-08329-5. Epub 2024 Dec 18. Nature. 2025. PMID: 39695227 Free PMC article.
Low-dose metformin targets the lysosomal AMPK pathway through PEN2.
Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, Wu J, Wei X, Qu Q, Yu Y, Long S, Feng JW, Li C, Zhang C, Xie C, Wu Y, Xu Z, Chen J, Yu Y, Huang X, He Y, Yao L, Zhang L, Zhu M, Wang W, Wang ZC, Zhang M, Bao Y, Jia W, Lin SY, Ye Z, Piao HL, Deng X, Zhang CS, Lin SC. Ma T, et al. Among authors: chen j. Nature. 2022 Mar;603(7899):159-165. doi: 10.1038/s41586-022-04431-8. Epub 2022 Feb 23. Nature. 2022. PMID: 35197629 Free PMC article.
Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity.
Zhai Y, Chen L, Zhao Q, Zheng ZH, Chen ZN, Bian H, Yang X, Lu HY, Lin P, Chen X, Chen R, Sun HY, Fan LN, Zhang K, Wang B, Sun XX, Feng Z, Zhu YM, Zhou JS, Chen SR, Zhang T, Chen SY, Chen JJ, Zhang K, Wang Y, Chang Y, Zhang R, Zhang B, Wang LJ, Li XM, He Q, Yang XM, Nan G, Xie RH, Yang L, Yang JH, Zhu P. Zhai Y, et al. Science. 2023 Mar 17;379(6637):eabg2482. doi: 10.1126/science.abg2482. Epub 2023 Mar 17. Science. 2023. PMID: 36927018
Targeting the glutamine-arginine-proline metabolism axis in cancer.
Wang D, Duan JJ, Guo YF, Chen JJ, Chen TQ, Wang J, Yu SC. Wang D, et al. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2367129. doi: 10.1080/14756366.2024.2367129. Epub 2024 Jul 25. J Enzyme Inhib Med Chem. 2024. PMID: 39051546 Free PMC article. Review.
Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing.
Qu Q, Chen Y, Wang Y, Wang W, Long S, Yang HY, Wu J, Li M, Tian X, Wei X, Liu YH, Xu S, Xiong J, Yang C, Wu Z, Huang X, Xie C, Wu Y, Xu Z, Zhang C, Zhang B, Feng JW, Chen J, Feng Y, Fang H, Lin L, Xie ZK, Sun B, Tian H, Yu Y, Piao HL, Xie XS, Deng X, Zhang CS, Lin SC. Qu Q, et al. Among authors: chen j. Nature. 2025 Jul;643(8070):201-209. doi: 10.1038/s41586-024-08348-2. Epub 2024 Dec 18. Nature. 2025. PMID: 39695235 Free PMC article.
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK.
Zhang CS, Li M, Wang Y, Li X, Zong Y, Long S, Zhang M, Feng JW, Wei X, Liu YH, Zhang B, Wu J, Zhang C, Lian W, Ma T, Tian X, Qu Q, Yu Y, Xiong J, Liu DT, Wu Z, Zhu M, Xie C, Wu Y, Xu Z, Yang C, Chen J, Huang G, He Q, Huang X, Zhang L, Sun X, Liu Q, Ghafoor A, Gui F, Zheng K, Wang W, Wang ZC, Yu Y, Zhao Q, Lin SY, Wang ZX, Piao HL, Deng X, Lin SC. Zhang CS, et al. Among authors: chen j. Nat Metab. 2022 Oct;4(10):1369-1401. doi: 10.1038/s42255-022-00640-7. Epub 2022 Oct 10. Nat Metab. 2022. PMID: 36217034 Free PMC article.
Authors' response.
Yi F, Liu OS, Lei L, Liu SL, Wang Y, Chu YH, Zhang LL, Li CR, Chen JJ, Lu YQ. Yi F, et al. Am J Orthod Dentofacial Orthop. 2023 Oct;164(4):463-464. doi: 10.1016/j.ajodo.2023.05.009. Am J Orthod Dentofacial Orthop. 2023. PMID: 37758399 No abstract available.
1,126 results