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Novel fungicidal benzylsulfanyl-phenylguanidines.
Thevissen K, Pellens K, De Brucker K, François IE, Chow KK, Meert EM, Meert W, Van Minnebruggen G, Borgers M, Vroome V, Levin J, De Vos D, Maes L, Cos P, Cammue BP. Thevissen K, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3686-92. doi: 10.1016/j.bmcl.2011.04.075. Epub 2011 Apr 24. Bioorg Med Chem Lett. 2011. PMID: 21576022
Compounds 665 and 666 combined potent fungicidal (MFC=5 muM) and bactericidal activity (minimal bactericidal concentration, MBC for S. epidermidis 4 muM). In an in vivo Caenorhabditis elegans model, compounds 665 and 667 exhibited less toxicity than 666 and 684. ...
Compounds 665 and 666 combined potent fungicidal (MFC=5 muM) and bactericidal activity (minimal bactericidal concentration, MBC for S