Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors.
Ni X, Richardson RB, Godoy AS, Ferla MP, Kikawa C, Scheen J, Hannon WW, Capkin E, Lahav N, Balcomb BH, Marples PG, Fairhead M, Wang S, Williams EP, Tomlinson CWE, Aschenbrenner JC, Lithgo RM, Winokan M, Giroud C, Dolci I, Fernandes RS, Oliva G, Chandran AV, Xavier MA, Walsh MA, Thompson W, Bloom JD, Kenton NT, Lee AA, von Delft A, Barr H, Kirkegaard K, Koekemoer L, Fearon D, Evans MJ, von Delft F.
Ni X, et al. Among authors: kirkegaard k.
Nat Commun. 2025 Oct 8;16(1):8930. doi: 10.1038/s41467-025-63602-z.
Nat Commun. 2025.
PMID: 41062463
Free PMC article.