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Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

Huang XP, Karpiak J, Kroeze WK, Zhu H, Chen X, Moy SS, Saddoris KA, Nikolova VD, Farrell MS, Wang S, Mangano TJ, Deshpande DA, Jiang A, Penn RB, Jin J, Koller BH, Kenakin T, Shoichet BK, Roth BL. Huang XP, et al. Among authors: karpiak j. Nature. 2015 Nov 26;527(7579):477-83. doi: 10.1038/nature15699. Epub 2015 Nov 9. Nature. 2015. PMID: 26550826 Free PMC article.

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Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs.

McCorvy JD, Butler KV, Kelly B, Rechsteiner K, Karpiak J, Betz RM, Kormos BL, Shoichet BK, Dror RO, Jin J, Roth BL. McCorvy JD, et al. Among authors: karpiak j. Nat Chem Biol. 2018 Feb;14(2):126-134. doi: 10.1038/nchembio.2527. Epub 2017 Dec 11. Nat Chem Biol. 2018. PMID: 29227473 Free PMC article.

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Structure, function and pharmacology of human itch GPCRs.

Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL. Cao C, et al. Among authors: karpiak j. Nature. 2021 Dec;600(7887):170-175. doi: 10.1038/s41586-021-04126-6. Epub 2021 Nov 17. Nature. 2021. PMID: 34789874

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Selectivity Challenges in Docking Screens for GPCR Targets and Antitargets.

Weiss DR, Karpiak J, Huang XP, Sassano MF, Lyu J, Roth BL, Shoichet BK. Weiss DR, et al. Among authors: karpiak j. J Med Chem. 2018 Aug 9;61(15):6830-6845. doi: 10.1021/acs.jmedchem.8b00718. Epub 2018 Jul 24. J Med Chem. 2018. PMID: 29990431 Free PMC article.

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Treatment outcomes of COVID-19 infected patients in bi-disciplinary cardiological and cardiac surgery ward.

Wójcik M, Gąsior A, Karpiak J, Chlebuś M, Romanek J, Rak M, Kolowca M, Widenka K, Przybylski A. Wójcik M, et al. Among authors: karpiak j. Kardiol Pol. 2021 Dec 31. doi: 10.33963/KP.a2021.0194. Online ahead of print. Kardiol Pol. 2021. PMID: 34970986 Free article. No abstract available.

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Density gradient multilayer polymerization for creating complex tissue.

Karpiak JV, Ner Y, Almutairi A. Karpiak JV, et al. Adv Mater. 2012 Mar 15;24(11):1466-70. doi: 10.1002/adma.201103501. Epub 2012 Feb 9. Adv Mater. 2012. PMID: 22318771 Free PMC article.

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In silico design of novel probes for the atypical opioid receptor MRGPRX2.

Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL. Lansu K, et al. Among authors: karpiak j. Nat Chem Biol. 2017 May;13(5):529-536. doi: 10.1038/nchembio.2334. Epub 2017 Mar 13. Nat Chem Biol. 2017. PMID: 28288109 Free PMC article.

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Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking.

Rettenmaier TJ, Fan H, Karpiak J, Doak A, Sali A, Shoichet BK, Wells JA. Rettenmaier TJ, et al. Among authors: karpiak j. J Med Chem. 2015 Oct 22;58(20):8285-8291. doi: 10.1021/acs.jmedchem.5b01216. Epub 2015 Oct 12. J Med Chem. 2015. PMID: 26443011 Free PMC article.

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Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes.

Salas-Sarduy E, Landaburu LU, Karpiak J, Madauss KP, Cazzulo JJ, Agüero F, Alvarez VE. Salas-Sarduy E, et al. Among authors: karpiak j. Sci Rep. 2017 Sep 21;7(1):12073. doi: 10.1038/s41598-017-12170-4. Sci Rep. 2017. PMID: 28935948 Free PMC article.

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Actin is required for IFT regulation in Chlamydomonas reinhardtii.

Avasthi P, Onishi M, Karpiak J, Yamamoto R, Mackinder L, Jonikas MC, Sale WS, Shoichet B, Pringle JR, Marshall WF. Avasthi P, et al. Among authors: karpiak j. Curr Biol. 2014 Sep 8;24(17):2025-32. doi: 10.1016/j.cub.2014.07.038. Epub 2014 Aug 21. Curr Biol. 2014. PMID: 25155506 Free PMC article.

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