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53 results

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Page 1
Whole-genome sequencing reveals host factors underlying critical COVID-19.
Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD, Verma A, Fowler TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A; GenOMICC investigators; 23andMe investigators; COVID-19 Human Genetics Initiative; Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK. Kousathanas A, et al. Nature. 2022 Jul;607(7917):97-103. doi: 10.1038/s41586-022-04576-6. Epub 2022 Mar 7. Nature. 2022. PMID: 35255492 Free PMC article.
Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f.
Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Veprintsev DB, Vaidehi N, Weyand SN, Tate CG. Gusach A, et al. Nat Commun. 2024 Aug 30;15(1):7555. doi: 10.1038/s41467-024-51793-w. Nat Commun. 2024. PMID: 39215004 Free PMC article.
There are two main families of G protein-coupled receptors that detect odours in humans, the odorant receptors (ORs) and the trace amine-associated receptors (TAARs). Their amino acid sequences are distinct, with the TAARs being most similar to the aminergic receptors such …
There are two main families of G protein-coupled receptors that detect odours in humans, the odorant receptors (ORs) and the trace am …
Immunonutrition.
Keith ME, Jeejeebhoy KN. Keith ME, et al. Baillieres Clin Endocrinol Metab. 1997 Dec;11(4):709-38. doi: 10.1016/s0950-351x(97)80990-1. Baillieres Clin Endocrinol Metab. 1997. PMID: 9589779 Review.
The immune system can be influenced by protein-energy malnutrition (PEM) and by catabolic illnesses such as sepsis and trauma, which in turn cause PEM. Specific trace element and vitamin deficiencies can also alter the immune state. However, overnutrition and obesity can a …
The immune system can be influenced by protein-energy malnutrition (PEM) and by catabolic illnesses such as sepsis and trauma, which in turn …
Aerospace Pressure Effects.
Tarver WJ, Volner K, Cooper JS. Tarver WJ, et al. 2022 Oct 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2022 Oct 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 29262037 Free Books & Documents.
This concept is important given that humans breathe air as a mixed gas of nitrogen (~78%), oxygen (~21%), and trace other gases. If the human body is exposed to a low enough absolute pressure, then surface fluids (tear film, saliva, and the air-exposed surface of alveoli) …
This concept is important given that humans breathe air as a mixed gas of nitrogen (~78%), oxygen (~21%), and trace other gases. If t …
Molecular recognition of an aversive odorant by the murine trace amine-associated receptor TAAR7f.
Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Verprintsev DB, Vaidehi N, Weyand SN, Tate CG. Gusach A, et al. bioRxiv [Preprint]. 2023 Jul 7:2023.07.07.547762. doi: 10.1101/2023.07.07.547762. bioRxiv. 2023. Update in: Nat Commun. 2024 Aug 30;15(1):7555. doi: 10.1038/s41467-024-51793-w. PMID: 37461561 Free PMC article. Updated. Preprint.
There are two main families of G protein-coupled receptors that detect odours in humans, the odorant receptors (ORs) and the trace amine-associated receptors (TAARs). Their amino acid sequences are distinct, with the TAARs being most similar to the aminergic receptors such …
There are two main families of G protein-coupled receptors that detect odours in humans, the odorant receptors (ORs) and the trace am …
The first intravenous anaesthetic: how well was it managed and its potential realized?
Dorrington KL, Poole W. Dorrington KL, et al. Br J Anaesth. 2013 Jan;110(1):7-12. doi: 10.1093/bja/aes388. Epub 2012 Nov 15. Br J Anaesth. 2013. PMID: 23161361 Free article. Review.
Our speciality commonly traces its origin to a demonstration of the inhalation of ether by a patient undergoing surgery in Boston in 1846. ...
Our speciality commonly traces its origin to a demonstration of the inhalation of ether by a patient undergoing surgery in Boston in …
CRISPR-induced DNA reorganization for multiplexed nucleic acid detection.
Karlikow M, Amalfitano E, Yang X, Doucet J, Chapman A, Mousavi PS, Homme P, Sutyrina P, Chan W, Lemak S, Yakunin AF, Dolezal AG, Kelley S, Foster LJ, Harpur BA, Pardee K. Karlikow M, et al. Nat Commun. 2023 Mar 17;14(1):1505. doi: 10.1038/s41467-023-36874-6. Nat Commun. 2023. PMID: 36932065 Free PMC article.
Here we report FACT (Functionalized Amplification CRISPR Tracing), a CRISPR-based nucleic acid barcoding technology compatible with Cas12a and Cas13a, enabling diagnostic outputs based on cis- and trans-cleavage from any sequence. ...
Here we report FACT (Functionalized Amplification CRISPR Tracing), a CRISPR-based nucleic acid barcoding technology compatible with C …
An outbreak of psittacosis.
Morrison WM, Hutchison RB, Thomason J, Harrington JH, Herd GW. Morrison WM, et al. J Infect. 1991 Jan;22(1):71-5. doi: 10.1016/0163-4453(91)91038-y. J Infect. 1991. PMID: 2002234
The origin of the outbreak seemed to be a local pet shop. The difficulties of diagnosis and tracing the connections with the pet shop are discussed. The clinical histories of the seven patients are described including those of the two who died....
The origin of the outbreak seemed to be a local pet shop. The difficulties of diagnosis and tracing the connections with the pet shop …
The morphology of the cardiac conduction system.
Anderson RH, Ho SY. Anderson RH, et al. Novartis Found Symp. 2003;250:6-17; discussion 18-24, 276-9. Novartis Found Symp. 2003. PMID: 12956321 Review.
Thus, it was Tawara (in 1906) who clarified the arrangement of the specialized muscular axis responsible for atrioventricular conduction, while Keith & Flack (in 1907) published the first account of the sinus node. Tawara's findings provide robust anatomic criteria for …
Thus, it was Tawara (in 1906) who clarified the arrangement of the specialized muscular axis responsible for atrioventricular conduction, wh …
ADAM "sequence" part II: hypothesis and speculation.
Opitz JM, Johnson DR, Gilbert-Barness EF. Opitz JM, et al. Am J Med Genet A. 2015 Mar;167A(3):478-503. doi: 10.1002/ajmg.a.36937. Epub 2015 Jan 21. Am J Med Genet A. 2015. PMID: 25604972 Review.
He concluded that an amniotic cord was "not an adhesion or inflammatory product but an anomalous developmental structure and present from the outset." In survivors the "traces" of damaged limb-buds "reveal the scars of poor germ-plasm." In 1958, Willis, in dismissing the a …
He concluded that an amniotic cord was "not an adhesion or inflammatory product but an anomalous developmental structure and present from th …
53 results