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Demographic, clinical, and ancestry characterization of a large cluster of mucopolysaccharidosis IV A in the Brazilian Northeast region.
Dos Santos-Lopes SS, de Oliveira JMF, de Queiroga Nascimento D, Montenegro YHA, Leistner-Segal S, Brusius-Facchin AC, Eufrazino Gondim C, Giugliani R, de Medeiros PFV. Dos Santos-Lopes SS, et al. Am J Med Genet A. 2021 Oct;185(10):2929-2940. doi: 10.1002/ajmg.a.62375. Epub 2021 Jun 2. Am J Med Genet A. 2021. PMID: 34076347
Paternal ancestry was 94.2% (16/17) European, 5.8% (1/17) African, and 0% Amerindian. The European paternal haplogroups R1a, R1b, and R* accounted for 94.2% (16/17) of the patients. The R1b haplogroup, identified in 59% (10/17) of the patients, is frequently found in popul …
Paternal ancestry was 94.2% (16/17) European, 5.8% (1/17) African, and 0% Amerindian. The European paternal haplogroups R1a, R1b, and R
Fluorimetric determination of aqueous formaldehyde employing heating and ultrasound-assisted approach through its derivatization with a ß-diketone-nickel(2+) complex immobilized in a PMMA flow cell.
de Araújo ALS, Cavalcante CO, Lavorante AF, Silva WE, Belian MF. de Araújo ALS, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2024 Apr 5;310:123792. doi: 10.1016/j.saa.2023.123792. Epub 2023 Dec 29. Spectrochim Acta A Mol Biomol Spectrosc. 2024. PMID: 38244431
Under the optimum experimental conditions, a linear response ranging from 1.0 to 10.0 mg/L FA (R = 0.997 and n = 10), and a detection (3sigma criterion) and quantification (10 sigma criterion) limit estimated at 0.129 and 0.389 mg/L, respectively were achieved. ...
Under the optimum experimental conditions, a linear response ranging from 1.0 to 10.0 mg/L FA (R = 0.997 and n = 10), and a detection …
Kinetics of the Reaction of OH with Isoprene over a Wide Range of Temperature and Pressure Including Direct Observation of Equilibrium with the OH Adducts.
Medeiros DJ, Blitz MA, James L, Speak TH, Seakins PW. Medeiros DJ, et al. J Phys Chem A. 2018 Sep 20;122(37):7239-7255. doi: 10.1021/acs.jpca.8b04829. Epub 2018 Sep 7. J Phys Chem A. 2018. PMID: 30137992 Free article.
Above 700 K, the OH decays were no longer single exponentials due to regeneration of OH from adduct decomposition and the establishment of the OH + C(5)H(8) HOC(5)H(8) equilibrium (R1a, R-1a). This equilibrium was analyzed by comparison to a master equation model of reacti …
Above 700 K, the OH decays were no longer single exponentials due to regeneration of OH from adduct decomposition and the establishment of t …
Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity.
Washburn N, Schwab I, Ortiz D, Bhatnagar N, Lansing JC, Medeiros A, Tyler S, Mekala D, Cochran E, Sarvaiya H, Garofalo K, Meccariello R, Meador JW 3rd, Rutitzky L, Schultes BC, Ling L, Avery W, Nimmerjahn F, Manning AM, Kaundinya GV, Bosques CJ. Washburn N, et al. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1297-306. doi: 10.1073/pnas.1422481112. Epub 2015 Mar 2. Proc Natl Acad Sci U S A. 2015. PMID: 25733881 Free PMC article.
Molecularly targeted drug combinations demonstrate selective effectiveness for myeloid- and lymphoid-derived hematologic malignancies.
Kurtz SE, Eide CA, Kaempf A, Khanna V, Savage SL, Rofelty A, English I, Ho H, Pandya R, Bolosky WJ, Poon H, Deininger MW, Collins R, Swords RT, Watts J, Pollyea DA, Medeiros BC, Traer E, Tognon CE, Mori M, Druker BJ, Tyner JW. Kurtz SE, et al. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7554-E7563. doi: 10.1073/pnas.1703094114. Epub 2017 Aug 7. Proc Natl Acad Sci U S A. 2017. PMID: 28784769 Free PMC article.
Evaluation of seeds ethanolic extracts of Triplaris gardneriana Wedd. using in vitro and in vivo toxicological methods.
Almeida TS, Arantes MR, Lopes Neto JJ, Souza TM, Pessoa IP, Medeiros JL, Tabosa PMS, Moreira TB, Farias DF, Carvalho AFU. Almeida TS, et al. J Toxicol Environ Health A. 2020 Feb 16;83(4):135-152. doi: 10.1080/15287394.2020.1731035. Epub 2020 Mar 2. J Toxicol Environ Health A. 2020. PMID: 32114934
The investigation provides important information on potentially adverse aspects of EETg, which need to be considered prior to the therapeutic utilization of this plant.Abbreviations: EETg: ethanolic extract of T. gardneriana seeds; MCF7: michigan cancer foundation-7 which refers …
The investigation provides important information on potentially adverse aspects of EETg, which need to be considered prior to the therapeuti …
Direct Trace Fitting of Experimental Data Using the Master Equation: Testing Theory and Experiments on the OH + C2H4 Reaction.
Medeiros DJ, Robertson SH, Blitz MA, Seakins PW. Medeiros DJ, et al. J Phys Chem A. 2020 May 21;124(20):4015-4024. doi: 10.1021/acs.jpca.0c02132. Epub 2020 May 11. J Phys Chem A. 2020. PMID: 32353235 Free article.
The time-resolved OH traces have been directly and globally fitted with a master equation in order to extract delta(R)H(0)(0), the binding energy of the HOC(2)H(4) adduct, with respect to reagents. The global approach allows the role that OH abstraction plays at higher tem …
The time-resolved OH traces have been directly and globally fitted with a master equation in order to extract delta(R)H(0)(0), the bi …