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Promotion of lipogenesis by PPARγ-activated FXR expression in adipocytes.

Shinohara S, Fujimori K. Shinohara S, et al. Among authors: fujimori k. Biochem Biophys Res Commun. 2020 Jun 18;527(1):49-55. doi: 10.1016/j.bbrc.2020.04.075. Epub 2020 Apr 24. Biochem Biophys Res Commun. 2020. PMID: 32446390

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Prostaglandin F_2α receptor antagonist attenuates LPS-induced systemic inflammatory response in mice.

Maehara T, Higashitarumi F, Kondo R, Fujimori K. Maehara T, et al. Among authors: fujimori k. FASEB J. 2020 Nov;34(11):15197-15207. doi: 10.1096/fj.202001481R. Epub 2020 Sep 28. FASEB J. 2020. PMID: 32985737

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L-PGDS-produced PGD₂ in premature, but not in mature, adipocytes increases obesity and insulin resistance.

Fujimori K, Aritake K, Oishi Y, Nagata N, Maehara T, Lazarus M, Urade Y. Fujimori K, et al. Sci Rep. 2019 Feb 13;9(1):1931. doi: 10.1038/s41598-018-38453-y. Sci Rep. 2019. PMID: 30760783 Free PMC article.

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Bicarbonate enhances the inflammatory response by activating JAK/STAT signalling in LPS + IFN-γ-stimulated macrophages.

Kawakami T, Koike A, Maehara T, Hayashi T, Fujimori K. Kawakami T, et al. Among authors: fujimori k. J Biochem. 2020 Jun 1;167(6):623-631. doi: 10.1093/jb/mvaa010. J Biochem. 2020. PMID: 31960927

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Contribution of FP receptors in M1 macrophage polarization via IL-10-regulated nuclear translocation of NF-κB p65.

Maehara T, Fujimori K. Maehara T, et al. Among authors: fujimori k. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 May;1865(5):158654. doi: 10.1016/j.bbalip.2020.158654. Epub 2020 Feb 6. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32036038

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Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages.

Koike A, Hanatani M, Fujimori K. Koike A, et al. Among authors: fujimori k. Exp Cell Res. 2019 Jul 15;380(2):171-179. doi: 10.1016/j.yexcr.2019.04.027. Epub 2019 Apr 27. Exp Cell Res. 2019. PMID: 31039349

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N¹-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR).

Masuda A, Gohda K, Iguchi Y, Fujimori K, Yamashita Y, Oda K, Une M, Teno N. Masuda A, et al. Among authors: fujimori k. Bioorg Med Chem. 2020 Jul 15;28(14):115512. doi: 10.1016/j.bmc.2020.115512. Epub 2020 May 23. Bioorg Med Chem. 2020. PMID: 32616182

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Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists.

Teno N, Yamashita Y, Masuda A, Iguchi Y, Oda K, Fujimori K, Hiramoto T, Nishimaki-Mogami T, Une M, Gohda K. Teno N, et al. Among authors: fujimori k. Bioorg Med Chem. 2019 Jun 1;27(11):2220-2227. doi: 10.1016/j.bmc.2019.04.029. Epub 2019 Apr 20. Bioorg Med Chem. 2019. PMID: 31029550

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A Limonoid, 7-Deacetoxy-7-Oxogedunin (CG-1) from Andiroba (Carapa guianensis, Meliaceae) Lowers the Accumulation of Intracellular Lipids in Adipocytes via Suppression of IRS-1/Akt-Mediated Glucose Uptake and a Decrease in GLUT4 Expression.

Matsumoto C, Koike A, Tanaka R, Fujimori K. Matsumoto C, et al. Among authors: fujimori k. Molecules. 2019 Apr 28;24(9):1668. doi: 10.3390/molecules24091668. Molecules. 2019. PMID: 31035366 Free PMC article.

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Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts.

Fujimori K, Iguchi Y, Yamashita Y, Gohda K, Teno N. Fujimori K, et al. Molecules. 2019 Nov 16;24(22):4155. doi: 10.3390/molecules24224155. Molecules. 2019. PMID: 31744088 Free PMC article.

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