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Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis.
Clausen TM, Weiss RJ, Tremblay JR, Kellman BP, Coker J, Dworkin LA, Rodriguez JP, Chang IM, Chen T, Padala V, Karlsson R, Song H, Peck KL, Ogawa S, Sandoval DR, Joshi HJ, Wang G, Ferguson LP, Bhalerao N, Moores A, Reya T, Sander M, Caffrey TC, Grem JL, Aicher A, Heeschen C, Le D, Lewis NE, Hollingsworth MA, Grandgenett PM, Bellis SL, Miller RL, Fuster MM, Dawson DW, Engle DD, Esko JD. Clausen TM, et al. Among authors: peck kl. J Clin Invest. 2025 Sep 16;135(22):e184172. doi: 10.1172/JCI184172. eCollection 2025 Nov 17. J Clin Invest. 2025. PMID: 40924474 Free PMC article.
Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis.
Osorio-Vasquez V, Zhu J, Lumibao JC, Lande K, Peck KL, Stamp MK, Okhovat SR, Song H, Ogawa S, Kubota CS, Pantazopoulou V, Curtis K, Kuo K, Dai Y, Rock A, Bottomley CR, Thomas EJ, Hsu J, Herrera Morales A, Fowler A, McGriff T, Evensen KG, Williams AE, Larsen S, Abdulla M, Greer P, Gibson J, Downes M, Evans RM, Lowy AM, Whitcomb DC, Zou J, Molinolo A, Oh TG, White RR, Bellin M, Tiriac H, Engle DD. Osorio-Vasquez V, et al. Among authors: peck kl. Cell Stem Cell. 2026 Aug 6;33(8):1270-1288.e7. doi: 10.1016/j.stem.2026.06.002. Epub 2026 Jun 30. Cell Stem Cell. 2026. PMID: 42379165 Free PMC article.
Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer.
Dufresne S, Kuna RS, Wong K, Komarla A, Rock A, Rosada-Encarnación J, Shen C, Mondal P, Parham LR, Izidro Layng F, Peck KL, Fowler A, Lowy AM, Engle D, Tiriac H, Shaw R, Cosford N, Metallo C, Towers C. Dufresne S, et al. Among authors: peck kl. bioRxiv [Preprint]. 2025 Jun 5:2025.05.29.656904. doi: 10.1101/2025.05.29.656904. bioRxiv. 2025. PMID: 40501952 Free PMC article. Preprint.
Chronic pancreatitis patient-derived organoids reveal new paths to precision therapeutics.
Osorio-Vasquez V, Zhu J, Lumibao JC, Lande K, Peck KL, Stamp MK, Okhovat SR, Song H, Ogawa S, Kubota C, Pantazopoulou V, Dai Y, Rock A, Bottomley C, Thomas E, Hsu J, Morales AH, Fowler A, McGriff T, Evensen KG, Larsen S, Abdulla M, Greer P, Gibson J, Downes M, Evans R, Lowy AM, Whitcomb DC, Zou J, Molinolo A, Oh TG, White R, Bellin M, Tiriac H, Engle DD. Osorio-Vasquez V, et al. Among authors: peck kl. bioRxiv [Preprint]. 2025 Nov 14:2024.10.30.620903. doi: 10.1101/2024.10.30.620903. bioRxiv. 2025. PMID: 41279927 Free PMC article. Preprint.
CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma.
Hsu J, Song H, Ogawa S, Kubota CS, Peck KL, Jacobs E, Garcia-Rivera L, Zhu J, Sui Y, Jung W, Dai Y, Lumibao J, Bottomley CR, Curtis K, Bau M, Ku E, Kuo K, Morales AH, Stamp M, Rock A, Okhovat SR, Hunter T, Downes M, Evans R, Zou J, Oh TG, Zheng Y, Lowy AM, Tiriac H, Kaech SM, Engle DD. Hsu J, et al. Among authors: peck kl. bioRxiv [Preprint]. 2026 May 26:2026.05.22.727290. doi: 10.64898/2026.05.22.727290. bioRxiv. 2026. PMID: 42244695 Free PMC article. Preprint.
CA19-9 promotes liver metastasis of pancreatic cancer through E-selectin mediated extravasation.
Ogawa S, Song H, Hsu J, Pantazopoulou V, Osorio-Vasquez V, Kubota CS, Tremblay JR, Bottomley CR, Lande K, Zhu J, Peck KL, Wang Y, Curtis K, Keightley S, Tomita R, Zou J, Downes M, Evans RM, Lowy AM, Tiriac H, Engle DD. Ogawa S, et al. Among authors: peck kl. bioRxiv [Preprint]. 2026 Apr 10:2026.04.08.717301. doi: 10.64898/2026.04.08.717301. bioRxiv. 2026. PMID: 41993312 Free PMC article. Preprint.