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SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype.

Yamamoto N, Ariumi Y, Nishida N, Yamamoto R, Bauer G, Gojobori T, Shimotohno K, Mizokami M. Yamamoto N, et al. Among authors: shimotohno k. Gene. 2020 Oct 20;758:144944. doi: 10.1016/j.gene.2020.144944. Epub 2020 Jul 3. Gene. 2020. PMID: 32628976 Free PMC article.

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HCV Assembly and Egress via Modifications in Host Lipid Metabolic Systems.

Shimotohno K. Shimotohno K. Cold Spring Harb Perspect Med. 2021 Jan 4;11(1):a036814. doi: 10.1101/cshperspect.a036814. Cold Spring Harb Perspect Med. 2021. PMID: 32122916 Review.

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Angiotensin-Converting Enzyme (ACE) 1 Gene Polymorphism and Phenotypic Expression of COVID-19 Symptoms.

Yamamoto N, Nishida N, Yamamoto R, Gojobori T, Shimotohno K, Mizokami M, Ariumi Y. Yamamoto N, et al. Among authors: shimotohno k. Genes (Basel). 2021 Oct 1;12(10):1572. doi: 10.3390/genes12101572. Genes (Basel). 2021. PMID: 34680966 Free PMC article. Review.

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N-Terminal PreS1 Sequence Regulates Efficient Infection of Cell-Culture-Generated Hepatitis B Virus.

Murayama A, Yamada N, Osaki Y, Shiina M, Aly HH, Iwamoto M, Tsukuda S, Watashi K, Matsuda M, Suzuki R, Tanaka T, Moriishi K, Suzuki T, Nishitsuji H, Sugiyama M, Mizokami M, Shimotohno K, Wakita T, Muramatsu M, Liang TJ, Kato T. Murayama A, et al. Among authors: shimotohno k. Hepatology. 2021 Feb;73(2):520-532. doi: 10.1002/hep.31308. Epub 2020 Oct 31. Hepatology. 2021. PMID: 32446278 Free PMC article.

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Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional Cure.

Honda T, Yamada N, Murayama A, Shiina M, Aly HH, Kato A, Ito T, Ishizu Y, Kuzuya T, Ishigami M, Murakami Y, Tanaka T, Moriishi K, Nishitsuji H, Shimotohno K, Ishikawa T, Fujishiro M, Muramatsu M, Wakita T, Kato T. Honda T, et al. Among authors: shimotohno k. Cell Mol Gastroenterol Hepatol. 2021;12(5):1583-1598. doi: 10.1016/j.jcmgh.2021.07.013. Epub 2021 Aug 2. Cell Mol Gastroenterol Hepatol. 2021. PMID: 34352407 Free PMC article.

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Strong alkaline electrolyzed water efficiently inactivates SARS-CoV-2, other viruses, and Gram-negative bacteria.

Suzuki Y, Hishiki T, Emi A, Sakaguchi S, Itamura R, Yamamoto R, Matsuzawa T, Shimotohno K, Mizokami M, Nakano T, Yamamoto N. Suzuki Y, et al. Among authors: shimotohno k. Biochem Biophys Res Commun. 2021 Oct 20;575:36-41. doi: 10.1016/j.bbrc.2021.08.048. Epub 2021 Aug 23. Biochem Biophys Res Commun. 2021. PMID: 34455219 Free PMC article.

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Role of microRNA-210-3p in hepatitis B virus-related hepatocellular carcinoma.

Morishita A, Fujita K, Iwama H, Chiyo T, Fujihara S, Oura K, Tadokoro T, Mimura S, Nomura T, Tani J, Yoneyama H, Kobayashi K, Kamada H, Guan Y, Nishiyama A, Okano K, Suzuki Y, Himoto T, Shimotohno K, Masaki T. Morishita A, et al. Among authors: shimotohno k. Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G401-G409. doi: 10.1152/ajpgi.00269.2019. Epub 2020 Jan 6. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 31905024 Free article.

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TIP60 Complex Inhibits Hepatitis B Virus Transcription.

Nishitsuji H, Ujino S, Harada K, Shimotohno K. Nishitsuji H, et al. Among authors: shimotohno k. J Virol. 2018 Feb 26;92(6):e01788-17. doi: 10.1128/JVI.01788-17. Print 2018 Mar 15. J Virol. 2018. PMID: 29321313 Free PMC article.

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In vitro models for analysis of the hepatitis C virus life cycle.

Aly HH, Shimotohno K, Hijikata M, Seya T. Aly HH, et al. Among authors: shimotohno k. Microbiol Immunol. 2012 Jan;56(1):1-9. doi: 10.1111/j.1348-0421.2011.00403.x. Microbiol Immunol. 2012. PMID: 22145950 Free article. Review.

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Does Genetic Predisposition Contribute to the Exacerbation of COVID-19 Symptoms in Individuals with Comorbidities and Explain the Huge Mortality Disparity between the East and the West?

Yamamoto N, Yamamoto R, Ariumi Y, Mizokami M, Shimotohno K, Yoshikura H. Yamamoto N, et al. Among authors: shimotohno k. Int J Mol Sci. 2021 May 8;22(9):5000. doi: 10.3390/ijms22095000. Int J Mol Sci. 2021. PMID: 34066804 Free PMC article. Review.

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