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Page 1
Molecular glue CELMoD compounds are regulators of cereblon conformation.
Watson ER, Novick S, Matyskiela ME, Chamberlain PP, H de la Peña A, Zhu J, Tran E, Griffin PR, Wertz IE, Lander GC. Watson ER, et al. Among authors: lander gc. Science. 2022 Nov 4;378(6619):549-553. doi: 10.1126/science.add7574. Epub 2022 Nov 3. Science. 2022. PMID: 36378961 Free PMC article.
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S, Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A, Chamberlain PP. Matyskiela ME, et al. Among authors: lander gc. Nature. 2016 Jul 14;535(7611):252-7. doi: 10.1038/nature18611. Epub 2016 Jun 22. Nature. 2016. PMID: 27338790
DELE1 oligomerization promotes integrated stress response activation.
Yang J, Baron KR, Pride DE, Schneemann A, Guo X, Chen W, Song AS, Aviles G, Kampmann M, Wiseman RL, Lander GC. Yang J, et al. Among authors: lander gc. Nat Struct Mol Biol. 2023 Sep;30(9):1295-1302. doi: 10.1038/s41594-023-01061-0. Epub 2023 Aug 7. Nat Struct Mol Biol. 2023. PMID: 37550454 Free PMC article.
Conquer by cryo-EM without physically dividing.
Lander GC, Glaeser RM. Lander GC, et al. Biochem Soc Trans. 2021 Nov 1;49(5):2287-2298. doi: 10.1042/BST20210360. Biochem Soc Trans. 2021. PMID: 34709401 Free PMC article. Review.
Structural basis for piRNA targeting.
Anzelon TA, Chowdhury S, Hughes SM, Xiao Y, Lander GC, MacRae IJ. Anzelon TA, et al. Among authors: lander gc. Nature. 2021 Sep;597(7875):285-289. doi: 10.1038/s41586-021-03856-x. Epub 2021 Sep 1. Nature. 2021. PMID: 34471284 Free PMC article.
Go hybrid: EM, crystallography, and beyond.
Lander GC, Saibil HR, Nogales E. Lander GC, et al. Curr Opin Struct Biol. 2012 Oct;22(5):627-35. doi: 10.1016/j.sbi.2012.07.006. Epub 2012 Jul 24. Curr Opin Struct Biol. 2012. PMID: 22835744 Free PMC article. Review.
112 results