Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control.
Chilloux J, Brial F, Everard A, Smyth D, Andrikopoulos P, Zhang L, Plovier H, Myridakis A, Hoyles L, Moreno-Navarrete JM, Luque JL, Casagrande V, Menghini R, Ahmetaj-Shala B, Blancher C, Martinez-Gili L, Gencer S, Fearnside JF, Barton RH, Neves AL, Rothwell AR, Gérard C, Calderari S, Williamson MJ, Fuchs JE, Govada L, Boulangé CL, Patel S, Scott J, Thursz M, Chayen N, Glen RC, Gooderham NJ, Nicholson JK, Federici M, Fernández-Real JM, Gauguier D, Liu PP, Cani PD, Dumas ME.
Chilloux J, et al. Among authors: govada l.
Nat Metab. 2025 Dec;7(12):2531-2547. doi: 10.1038/s42255-025-01413-8. Epub 2025 Dec 8.
Nat Metab. 2025.
PMID: 41361024
Free PMC article.