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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
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2006 1
2007 1
2009 1
2020 1
2022 2
2023 3
2024 0

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Page 1
Metabolism-Guided Optimization of Tryptophanol-Derived Isoindolinone p53 Activators.
Barcherini V, Loureiro JB, Sena A, Madeira C, Leandro P, Saraiva L, Antunes AMM, Santos MMM. Barcherini V, et al. Pharmaceuticals (Basel). 2023 Jan 19;16(2):146. doi: 10.3390/ph16020146. Pharmaceuticals (Basel). 2023. PMID: 37259297 Free PMC article.
From the metabolites' identification, performed by liquid chromatography coupled to high resolution tandem mass spectrometry (LC-HRMS/MS), followed by their preparation and structural elucidation, it was possible to identify that the indole C2 and C3 are the main target of …
From the metabolites' identification, performed by liquid chromatography coupled to high resolution tandem mass spectrometry (LC-HRMS/MS), f …
Monoclonal Antibodies, Gene Silencing and Gene Editing (CRISPR) Therapies for the Treatment of Hyperlipidemia-The Future Is Here.
Hermel M, Lieberman M, Slipczuk L, Rana JS, Virani SS. Hermel M, et al. Pharmaceutics. 2023 Jan 30;15(2):459. doi: 10.3390/pharmaceutics15020459. Pharmaceutics. 2023. PMID: 36839781 Free PMC article. Review.
The current era of cutting-edge pharmaceuticals targeting low density lipoprotein cholesterol, PCSK9, lipoprotein (a), angiopoietin-like 3, and apolipoprotein C3 are reviewed. We outline what is known, studies in progress, and futuristic goals. ...
The current era of cutting-edge pharmaceuticals targeting low density lipoprotein cholesterol, PCSK9, lipoprotein (a), angiopoietin-like 3, …
Acyl-CoA dehydrogenase substrate promiscuity: Challenges and opportunities for development of substrate reduction therapy in disorders of valine and isoleucine metabolism.
Houten SM, Dodatko T, Dwyer W, Violante S, Chen H, Stauffer B, DeVita RJ, Vaz FM, Cross JR, Yu C, Leandro J. Houten SM, et al. J Inherit Metab Dis. 2023 Sep;46(5):931-942. doi: 10.1002/jimd.12642. Epub 2023 Jun 19. J Inherit Metab Dis. 2023. PMID: 37309295
MCPA treatment of wild-type and PA HEK-293 cells caused a pronounced decrease in C3-carnitine. Furthermore, deletion of ACADSB in HEK-293 cells led to an equally strong decrease in C3-carnitine when compared to wild-type cells. ...
MCPA treatment of wild-type and PA HEK-293 cells caused a pronounced decrease in C3-carnitine. Furthermore, deletion of ACADSB in HEK …
Dihydroeugenol derivatives associated with blue LED light: A different form to face multidrug resistant (MDR) bacteria.
de Sousa AK, Rocha JE, de Freitas TS, Freitas PR, Pereira RLS, Leandro MKDNS, Machado JVC, de Oliveira LM, Torres Sierra EJ, Pereira Júnior FN, Carvalho DT, Coutinho HDM, Quintans Júnior LJ. de Sousa AK, et al. Microb Pathog. 2022 Dec;173(Pt A):105827. doi: 10.1016/j.micpath.2022.105827. Epub 2022 Oct 13. Microb Pathog. 2022. PMID: 36243385
Afterward, the plates were submitted to blue LED light for 20 min. When exposed to LED, C3 exhibited a decrease in MIC for SA ATCC and C5 for EC ATCC, with an average of 645.08 mug/mL for both cases. C2 and C4 exhibited synergism in a greater number of situations. However, …
Afterward, the plates were submitted to blue LED light for 20 min. When exposed to LED, C3 exhibited a decrease in MIC for SA ATCC an …
Disparity in peripheral and renal B-cell depletion with rituximab in systemic lupus erythematosus: an opportunity for obinutuzumab?
Reddy VR, Pepper RJ, Shah K, Cambridge G, Henderson SR, Klein C, Kell L, Taylor SJ, Isenberg DA, Cragg MS, Leandro MJ. Reddy VR, et al. Rheumatology (Oxford). 2022 Jul 6;61(7):2894-2904. doi: 10.1093/rheumatology/keab827. Rheumatology (Oxford). 2022. PMID: 34788412 Free PMC article.
There were no significant relationships between peripheral BCD and patient age, disease duration, serum C3 levels or the level of expression of B cell surface proteins CD20 and FcgammaRIIb. ...
There were no significant relationships between peripheral BCD and patient age, disease duration, serum C3 levels or the level of exp …
Effects of maternal protein restriction on central and peripheral renin-angiotensin systems in male rat offspring.
Barros MAV, de Brito Alves JL, Barros RGN, Santana E Silva M, Nasser S, Tourneur Y, Leandro CVG, Vidal H, Pirola L, Costa-Silva JH. Barros MAV, et al. Life Sci. 2020 Dec 15;263:118574. doi: 10.1016/j.lfs.2020.118574. Epub 2020 Oct 10. Life Sci. 2020. PMID: 33049280 Free article.
The peripheral chemoreflex was similar between the groups. LP group had lower gene expression of Rac1 (Ras-related C3 botulinum toxin substrate 1) (NP: 1.13 0.06 vs. LP: 0.88 0.08). ...
The peripheral chemoreflex was similar between the groups. LP group had lower gene expression of Rac1 (Ras-related C3 botulinum toxin …
B cell depletion therapy in systemic lupus erythematosus: long-term follow-up and predictors of response.
Ng KP, Cambridge G, Leandro MJ, Edwards JC, Ehrenstein M, Isenberg DA. Ng KP, et al. Ann Rheum Dis. 2007 Sep;66(9):1259-62. doi: 10.1136/ard.2006.067124. Epub 2007 Apr 5. Ann Rheum Dis. 2007. PMID: 17412738 Free PMC article.
Baseline anti-extractable nuclear antigen (ENA) was the only identified independent predictor of flare post-BCDT (p = 0.034, odds ratio = 8, 95% CI 1.2 to 55) from multivariable analysis. Patients with low baseline serum C3 had a shorter time to flare post-BCDT (p = 0.008) …
Baseline anti-extractable nuclear antigen (ENA) was the only identified independent predictor of flare post-BCDT (p = 0.034, odds ratio = 8, …
An open study of B lymphocyte depletion in systemic lupus erythematosus.
Leandro MJ, Edwards JC, Cambridge G, Ehrenstein MR, Isenberg DA. Leandro MJ, et al. Arthritis Rheum. 2002 Oct;46(10):2673-7. doi: 10.1002/art.10541. Arthritis Rheum. 2002. PMID: 12384926 Free article. Clinical Trial.
In patients 4 and 5, the urinary protein-to-creatinine ratio decreased significantly. C3 serum levels increased in all 5 patients who had low levels at baseline; in two of these patients, patients 2 and 5, C3 values were normal at 6 months. ...
In patients 4 and 5, the urinary protein-to-creatinine ratio decreased significantly. C3 serum levels increased in all 5 patients who …
B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients.
Leandro MJ, Cambridge G, Edwards JC, Ehrenstein MR, Isenberg DA. Leandro MJ, et al. Rheumatology (Oxford). 2005 Dec;44(12):1542-5. doi: 10.1093/rheumatology/kei080. Epub 2005 Sep 27. Rheumatology (Oxford). 2005. PMID: 16188950 Clinical Trial.
Disease activity in these patients was assessed every 1-2 months using the British Isles Lupus Assessment Group (BILAG) system and estimates of anti-double-stranded DNA antibodies and serum C3 levels. During the follow-up period, significant side-effects were sought and th …
Disease activity in these patients was assessed every 1-2 months using the British Isles Lupus Assessment Group (BILAG) system and estimates …
11 results