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Year Number of Results
2020 4
2021 2
2022 5
2023 3
2024 2
2025 6
2026 3

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23 results

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Page 1
Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection.
Broomfield BJ, Tan CW, Qin RZ, Abberger H, Duckworth BC, Alvarado C, Dalit L, Lee CL, Shandre Mugan R, Mazrad ZAI, Muramatsu H, Mackiewicz L, Williams BE, Chen J, Takanashi A, Fabb S, Pellegrini M, Rogers KL, Moon WJ, Pouton CW, Davis MJ, Nutt SL, Pardi N, Wimmer VC, Groom JR. Broomfield BJ, et al. Among authors: mackiewicz l. J Exp Med. 2025 May 5;222(5):e20241148. doi: 10.1084/jem.20241148. Epub 2025 Mar 10. J Exp Med. 2025. PMID: 40062995 Free PMC article.
Combination antiretroviral therapy and MCL-1 inhibition mitigate HTLV-1 infection in vivo.
Cooney JP, Hirons A, Jansz N, Allison CC, Hickey P, Teh CE, Tan T, Dagley LF, Yousef J, Yurick D, Khoury G, Preston SP, Arandjelovic P, Davidson KC, Williams LJ, Bader SM, Wang L, Bhandari R, Mackiewicz L, Dayton M, Clow W, Faulkner GJ, Gray DH, Einsiedel L, Purcell DFJ, Doerflinger M, Pellegrini M. Cooney JP, et al. Among authors: mackiewicz l. Cell. 2025 Sep 4;188(18):4896-4912.e19. doi: 10.1016/j.cell.2025.06.023. Epub 2025 Jul 10. Cell. 2025. PMID: 40645177 Free article.
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.
Simpson DS, Pang J, Weir A, Kong IY, Fritsch M, Rashidi M, Cooney JP, Davidson KC, Speir M, Djajawi TM, Hughes S, Mackiewicz L, Dayton M, Anderton H, Doerflinger M, Deng Y, Huang AS, Conos SA, Tye H, Chow SH, Rahman A, Norton RS, Naderer T, Nicholson SE, Burgio G, Man SM, Groom JR, Herold MJ, Hawkins ED, Lawlor KE, Strasser A, Silke J, Pellegrini M, Kashkar H, Feltham R, Vince JE. Simpson DS, et al. Among authors: mackiewicz l. Immunity. 2022 Mar 8;55(3):423-441.e9. doi: 10.1016/j.immuni.2022.01.003. Epub 2022 Feb 8. Immunity. 2022. PMID: 35139355 Free PMC article.
Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection.
M Bader S, Scherer L, Bhandari R, Motyer AJ, Cooney JP, Mackiewicz L, Dayton M, Sheerin D, V L Romero D, Schaefer J, Pang J, Chen S, Schoffer K, Wang L, Jin X, Batey D, Yip RKH, Zaman I, Rajasekhar P, Gartner MJ, Wilcox S, Whitehead L, Georgy SR, Maluenda A, Davidson KC, Allison CC, Bowden R, Brinkmann K, Asselin-Labat ML, Phipson B, Tanzer MC, Herold MJ, Samson AL, Vince JE, Strasser A, Pellegrini M, Doerflinger M. M Bader S, et al. Among authors: mackiewicz l. Nat Commun. 2025 Nov 13;16(1):9822. doi: 10.1038/s41467-025-65098-z. Nat Commun. 2025. PMID: 41233351 Free PMC article.
Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner.
Kleeman EA, Gubert C, Reisinger SN, Davidson KC, Lu D, Dayton M, Mackiewicz L, Masson BA, Adithya P, Garnham AL, Stathatos G, O'Bryan MK, R Muralitharan R, Marques FZ, Li S, Liao H, McLaughlin S, Keough ET, Wheeler MY, Kiridena P, Doerflinger M, Pellegrini M, Hannan AJ. Kleeman EA, et al. Among authors: mackiewicz l. Nat Commun. 2025 Oct 11;16(1):9045. doi: 10.1038/s41467-025-64473-0. Nat Commun. 2025. PMID: 41076487 Free PMC article.
A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.
M Bader S, Calleja DJ, Devine SM, Kuchel NW, Lu BGC, Wu X, Birkinshaw RW, Bhandari R, Loi K, Volpe R, Khakham Y, Au AE, Blackmore TR, Mackiewicz L, Dayton M, Schaefer J, Scherer L, Stock AT, Cooney JP, Schoffer K, Maluenda A, Kleeman EA, Davidson KC, Allison CC, Ebert G, Chen G, Katneni K, Klemm TA, Nachbur U, Georgy SR, Czabotar PE, Hannan AJ, Putoczki TL, Tanzer M, Pellegrini M, Lechtenberg BC, Charman SA, Call MJ, Mitchell JP, Lowes KN, Lessene G, Doerflinger M, Komander D. M Bader S, et al. Among authors: mackiewicz l. Nat Commun. 2025 Apr 3;16(1):2900. doi: 10.1038/s41467-025-57905-4. Nat Commun. 2025. PMID: 40180914 Free PMC article.
Efferocytosis of apoptotic bodies drives SARS-CoV-2 infection and macrophage inflammation.
Phan TK, Sheerin D, Shi B, Chua NK, Gummadi S, Dayton M, Mackiewicz L, Maluenda A, Ozkocak DC, Atkin-Smith GK, Peton N, Ang CS, Audi O, Thinh Le Q, Tran TU, Tu TM, Tixeira R, Ashdown GW, Davidson KC, Fonseka P, Feltham R, Doerflinger M, Hulett MD, Coussens AK, Poon IKH. Phan TK, et al. Among authors: mackiewicz l. Nat Commun. 2026 Jun 15;17(1):7535. doi: 10.1038/s41467-026-74363-8. Nat Commun. 2026. PMID: 42297820 Free PMC article.
Targeting rapidly cycling receptors CD2 and CD7 increases nanoparticle delivery to primary CD4+ T cells.
Cevaal PM, Ali A, Doerflinger M, Cortez-Jugo C, Tan A, Liu H, Chen MZ, Wang L, Dayton M, Mackiewicz L, Kan S, Faria M, Gubser C, Lafleur RPM, De Rose R, Johnston APR, Caruso F, Roche M, Symons J, Lewin SR. Cevaal PM, et al. Among authors: mackiewicz l. Nat Commun. 2026 Jul 1;17(1):8204. doi: 10.1038/s41467-026-74981-2. Nat Commun. 2026. PMID: 42386746 Free PMC article.
Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria.
Bader SM, Preston SP, Saliba K, Lipszyc A, Grant ZL, Mackiewicz L, Baldi A, Hempel A, Clark MP, Peiris T, Clow W, Bjelic J, Stutz MD, Arandjelovic P, Teale J, Du F, Coultas L, Murphy JM, Allison CC, Pellegrini M, Samson AL. Bader SM, et al. Among authors: mackiewicz l. Cell Death Differ. 2023 Jan;30(1):27-36. doi: 10.1038/s41418-022-01042-8. Epub 2022 Jul 23. Cell Death Differ. 2023. PMID: 35871233 Free PMC article.
23 results