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Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, Serchov T, Diniz CRAF, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castrén E. Casarotto PC, et al. Among authors: laukkanen l. Cell. 2021 Mar 4;184(5):1299-1313.e19. doi: 10.1016/j.cell.2021.01.034. Epub 2021 Feb 18. Cell. 2021. PMID: 33606976 Free PMC article.
Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior.
Tikker L, Casarotto P, Singh P, Biojone C, Piepponen TP, Estartús N, Seelbach A, Sridharan R, Laukkanen L, Castrén E, Partanen J. Tikker L, et al. Among authors: laukkanen l. J Neurosci. 2020 Nov 4;40(45):8669-8682. doi: 10.1523/JNEUROSCI.2252-19.2020. Epub 2020 Oct 12. J Neurosci. 2020. PMID: 33046550 Free PMC article.