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To Kill a Microglia: A Case for CSF1R Inhibitors.

Green KN, Crapser JD, Hohsfield LA. Green KN, et al. Among authors: hohsfield la. Trends Immunol. 2020 Sep;41(9):771-784. doi: 10.1016/j.it.2020.07.001. Epub 2020 Aug 10. Trends Immunol. 2020. PMID: 32792173 Free PMC article. Review.

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Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.

Spangenberg E, Severson PL, Hohsfield LA, Crapser J, Zhang J, Burton EA, Zhang Y, Spevak W, Lin J, Phan NY, Habets G, Rymar A, Tsang G, Walters J, Nespi M, Singh P, Broome S, Ibrahim P, Zhang C, Bollag G, West BL, Green KN. Spangenberg E, et al. Among authors: hohsfield la. Nat Commun. 2019 Aug 21;10(1):3758. doi: 10.1038/s41467-019-11674-z. Nat Commun. 2019. PMID: 31434879 Free PMC article.

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Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain.

Crapser JD, Spangenberg EE, Barahona RA, Arreola MA, Hohsfield LA, Green KN. Crapser JD, et al. Among authors: hohsfield la. EBioMedicine. 2020 Aug;58:102919. doi: 10.1016/j.ebiom.2020.102919. Epub 2020 Jul 31. EBioMedicine. 2020. PMID: 32745992 Free PMC article.

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Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R^+/- mouse model of ALSP, which can be rescued via CSF1R inhibitors.

Arreola MA, Soni N, Crapser JD, Hohsfield LA, Elmore MRP, Matheos DP, Wood MA, Swarup V, Mortazavi A, Green KN. Arreola MA, et al. Among authors: hohsfield la. Sci Adv. 2021 Aug 25;7(35):eabg1601. doi: 10.1126/sciadv.abg1601. Print 2021 Aug. Sci Adv. 2021. PMID: 34433559 Free PMC article.

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Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice.

Elmore MRP, Hohsfield LA, Kramár EA, Soreq L, Lee RJ, Pham ST, Najafi AR, Spangenberg EE, Wood MA, West BL, Green KN. Elmore MRP, et al. Among authors: hohsfield la. Aging Cell. 2018 Dec;17(6):e12832. doi: 10.1111/acel.12832. Epub 2018 Oct 2. Aging Cell. 2018. PMID: 30276955 Free PMC article.

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Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave.

Hohsfield LA, Najafi AR, Ghorbanian Y, Soni N, Crapser J, Figueroa Velez DX, Jiang S, Royer SE, Kim SJ, Henningfield CM, Anderson A, Gandhi SP, Mortazavi A, Inlay MA, Green KN. Hohsfield LA, et al. Elife. 2021 Aug 23;10:e66738. doi: 10.7554/eLife.66738. Elife. 2021. PMID: 34423781 Free PMC article.

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Childbearing vs. clinical trial participation: is it one or the other?

Hernandez SJ, Hohsfield LA. Hernandez SJ, et al. Among authors: hohsfield la. J Transl Med. 2021 Jun 15;19(1):260. doi: 10.1186/s12967-021-02930-2. J Transl Med. 2021. PMID: 34130723 Free PMC article.

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Migration of blood cells to β-amyloid plaques in Alzheimer's disease.

Hohsfield LA, Humpel C. Hohsfield LA, et al. Exp Gerontol. 2015 May;65:8-15. doi: 10.1016/j.exger.2015.03.002. Epub 2015 Mar 6. Exp Gerontol. 2015. PMID: 25752742 Free PMC article. Review.

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Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic mice.

Olivarria GM, Cheng Y, Furman S, Pachow C, Hohsfield LA, Smith-Geater C, Miramontes R, Wu J, Burns MS, Tsourmas KI, Stocksdale J, Manlapaz C, Yong WH, Teijaro J, Edwards R, Green KN, Thompson LM, Lane TE. Olivarria GM, et al. Among authors: hohsfield la. bioRxiv. 2021 Nov 17:2021.11.15.468761. doi: 10.1101/2021.11.15.468761. Preprint. bioRxiv. 2021. PMID: 34816260 Free PMC article. Updated.

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Effects of long-term and brain-wide colonization of peripheral bone marrow-derived myeloid cells in the CNS.

Hohsfield LA, Najafi AR, Ghorbanian Y, Soni N, Hingco EE, Kim SJ, Jue AD, Swarup V, Inlay MA, Green KN. Hohsfield LA, et al. J Neuroinflammation. 2020 Sep 20;17(1):279. doi: 10.1186/s12974-020-01931-0. J Neuroinflammation. 2020. PMID: 32951604 Free PMC article.

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