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A plant-based transient expression system for the rapid production of highly immunogenic Hepatitis E virus-like particles.
Mardanova ES, Takova KH, Toneva VT, Zahmanova GG, Tsybalova LM, Ravin NV. Mardanova ES, et al. Among authors: tsybalova lm. Biotechnol Lett. 2020 Nov;42(11):2441-2446. doi: 10.1007/s10529-020-02995-x. Epub 2020 Sep 1. Biotechnol Lett. 2020. PMID: 32875477
Highly Immunogenic Nanoparticles Based on a Fusion Protein Comprising the M2e of Influenza A Virus and a Lipopeptide.
Zykova AA, Blokhina EA, Kotlyarov RY, Stepanova LA, Tsybalova LM, Kuprianov VV, Ravin NV. Zykova AA, et al. Among authors: tsybalova lm. Viruses. 2020 Oct 6;12(10):E1133. doi: 10.3390/v12101133. Viruses. 2020. PMID: 33036278 Free PMC article.
Plant-Produced Recombinant Influenza A Virus Candidate Vaccine Based on Flagellin Linked to Conservative Fragments of M2 Protein and Hemagglutintin.
Blokhina EA, Mardanova ES, Stepanova LA, Tsybalova LM, Ravin NV. Blokhina EA, et al. Among authors: tsybalova lm. Plants (Basel). 2020 Jan 29;9(2):162. doi: 10.3390/plants9020162. Plants (Basel). 2020. PMID: 32013187 Free PMC article.
Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various influenza viruses a subtypes.
Stepanova LA, Mardanova ES, Shuklina MA, Blokhina EA, Kotlyarov RY, Potapchuk MV, Kovaleva AA, Vidyaeva IG, Korotkov AV, Eletskaya EI, Ravin NV, Tsybalova LM. Stepanova LA, et al. Among authors: tsybalova lm. J Biomed Sci. 2018 Apr 9;25(1):33. doi: 10.1186/s12929-018-0433-5. J Biomed Sci. 2018. PMID: 29631629 Free PMC article.
Combination of M2e peptide with stalk HA epitopes of influenza A virus enhances protective properties of recombinant vaccine.
Tsybalova LM, Stepanova LA, Shuklina MA, Mardanova ES, Kotlyarov RY, Potapchuk MV, Petrov SA, Blokhina EA, Ravin NV. Tsybalova LM, et al. PLoS One. 2018 Aug 23;13(8):e0201429. doi: 10.1371/journal.pone.0201429. eCollection 2018. PLoS One. 2018. PMID: 30138320 Free PMC article.
High immunogenicity of plant-produced candidate influenza vaccine based on the M2e peptide fused to flagellin.
Mardanova ES, Kotlyarov RY, Kuprianov VV, Stepanova LA, Tsybalova LM, Lomonossoff GP, Ravin NV. Mardanova ES, et al. Among authors: tsybalova lm. Bioengineered. 2016;7(1):28-32. doi: 10.1080/21655979.2015.1126017. Epub 2015 Dec 28. Bioengineered. 2016. PMID: 26710263 Free PMC article.
Efficient Transient Expression of Recombinant Proteins in Plants by the Novel pEff Vector Based on the Genome of Potato Virus X.
Mardanova ES, Blokhina EA, Tsybalova LM, Peyret H, Lomonossoff GP, Ravin NV. Mardanova ES, et al. Among authors: tsybalova lm. Front Plant Sci. 2017 Feb 28;8:247. doi: 10.3389/fpls.2017.00247. eCollection 2017. Front Plant Sci. 2017. PMID: 28293244 Free PMC article.
Protection against multiple influenza A virus strains induced by candidate recombinant vaccine based on heterologous M2e peptides linked to flagellin.
Stepanova LA, Kotlyarov RY, Kovaleva AA, Potapchuk MV, Korotkov AV, Sergeeva MV, Kasianenko MA, Kuprianov VV, Ravin NV, Tsybalova LM, Skryabin KG, Kiselev OI. Stepanova LA, et al. Among authors: tsybalova lm. PLoS One. 2015 Mar 23;10(3):e0119520. doi: 10.1371/journal.pone.0119520. eCollection 2015. PLoS One. 2015. PMID: 25799221 Free PMC article.
Development of a candidate influenza vaccine based on virus-like particles displaying influenza M2e peptide into the immunodominant loop region of hepatitis B core antigen: Insertion of multiple copies of M2e increases immunogenicity and protective efficiency.
Ravin NV, Blokhina EA, Kuprianov VV, Stepanova LA, Shaldjan AA, Kovaleva AA, Tsybalova LM, Skryabin KG. Ravin NV, et al. Among authors: tsybalova lm. Vaccine. 2015 Jun 26;33(29):3392-7. doi: 10.1016/j.vaccine.2015.04.066. Epub 2015 Apr 29. Vaccine. 2015. PMID: 25937448
Development of a candidate influenza vaccine based on virus-like particles displaying influenza M2e peptide into the immunodominant region of hepatitis B core antigen: Broad protective efficacy of particles carrying four copies of M2e.
Tsybalova LM, Stepanova LA, Kuprianov VV, Blokhina EA, Potapchuk MV, Korotkov AV, Gorshkov AN, Kasyanenko MA, Ravin NV, Kiselev OI. Tsybalova LM, et al. Vaccine. 2015 Jun 26;33(29):3398-406. doi: 10.1016/j.vaccine.2015.04.073. Epub 2015 May 11. Vaccine. 2015. PMID: 25976545
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