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Targeted treatment of severe vascular malformations harboring PIK3CA and TEK mutations with alpelisib is highly effective with limited toxicity.
Sterba M, Pokorna P, Faberova R, Pinkova B, Skotakova J, Seehofnerova A, Blatny J, Janigova L, Koskova O, Palova H, Mahdal M, Pazourek L, Jabandziev P, Slaby O, Mudry P, Sterba J. Sterba M, et al. Among authors: pazourek l. Sci Rep. 2023 Jun 28;13(1):10499. doi: 10.1038/s41598-023-37468-4. Sci Rep. 2023. PMID: 37380669 Free PMC article.
New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRβ Signaling.
Mahdal M, Neradil J, Mudry P, Paukovcekova S, Staniczkova Zambo I, Urban J, Macsek P, Pazourek L, Tomas T, Veselska R. Mahdal M, et al. Among authors: pazourek l. Cancers (Basel). 2021 Jul 15;13(14):3543. doi: 10.3390/cancers13143543. Cancers (Basel). 2021. PMID: 34298757 Free PMC article.