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1989 2
1990 1
1992 2
1993 3
1994 2
1995 1
1996 1
1999 2
2000 4
2001 1
2003 2
2004 2
2005 5
2006 1
2007 6
2008 3
2009 3
2010 2
2011 1
2012 3
2013 4
2014 2
2015 1
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2024 0

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74 results

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Page 1
Complement amplification revisited.
Lutz HU, Jelezarova E. Lutz HU, et al. Mol Immunol. 2006 Jan;43(1-2):2-12. doi: 10.1016/j.molimm.2005.06.020. Mol Immunol. 2006. PMID: 16023211 Review.
Complement amplification in blood takes place not only on activating surfaces, but in plasma as well, where it is maintained primarily by C3b2-IgG complexes. Regular products of C3 activation in serum, these complexes are inherently very efficient precursors of the alterna …
Complement amplification in blood takes place not only on activating surfaces, but in plasma as well, where it is maintained primarily by C3 …
Homeostatic roles of naturally occurring antibodies: an overview.
Lutz HU. Lutz HU. J Autoimmun. 2007 Dec;29(4):287-94. doi: 10.1016/j.jaut.2007.07.007. Epub 2007 Sep 12. J Autoimmun. 2007. PMID: 17826952 Review.
IgG NAbs to an exposed protein, band 3 from red blood cells, bind to oligomerized band 3 and due to an affinity for C3 within their framework preferentially form C3b2-IgG complexes from nascent C3b. Thus, anti-band 3 NAbs gain potency by using avidity and generating a pote …
IgG NAbs to an exposed protein, band 3 from red blood cells, bind to oligomerized band 3 and due to an affinity for C3 within their f …
Membranoproliferative glomerulonephritis type II (dense deposit disease): an update.
Appel GB, Cook HT, Hageman G, Jennette JC, Kashgarian M, Kirschfink M, Lambris JD, Lanning L, Lutz HU, Meri S, Rose NR, Salant DJ, Sethi S, Smith RJ, Smoyer W, Tully HF, Tully SP, Walker P, Welsh M, Würzner R, Zipfel PF. Appel GB, et al. J Am Soc Nephrol. 2005 May;16(5):1392-403. doi: 10.1681/ASN.2005010078. Epub 2005 Mar 30. J Am Soc Nephrol. 2005. PMID: 15800116 Review.
The pathophysiologic basis of MPGN II is associated with the uncontrolled systemic activation of the alternative pathway (AP) of the complement cascade. In most patients, loss of complement regulation is caused by C3 nephritic factor, an autoantibody directed against the …
The pathophysiologic basis of MPGN II is associated with the uncontrolled systemic activation of the alternative pathway (AP) of the complem …
Stimulation of complement amplification by F(ab')(2)-containing immune complexes and naturally occurring anti-hinge antibodies, possible role in systemic inflammation.
Lutz HU, Fumia S. Lutz HU, et al. Autoimmun Rev. 2008 Jun;7(6):508-13. doi: 10.1016/j.autrev.2008.04.017. Epub 2008 May 12. Autoimmun Rev. 2008. PMID: 18558371 Review.
Immune complexes containing IgG (IgG-IC) rarely stimulate complement amplification in human plasma. IgG molecules doing so may have an affinity for C3 within their framework and therefore preferentially generate C3b(2)-IgG complexes, potent C3 convertase precursors. …
Immune complexes containing IgG (IgG-IC) rarely stimulate complement amplification in human plasma. IgG molecules doing so may have an affin …
How immune complexes from certain IgG NAbs and any F(ab')₂ can mediate excessive complement activation.
Lutz HU. Lutz HU. Adv Exp Med Biol. 2012;750:186-96. doi: 10.1007/978-1-4614-3461-0_14. Adv Exp Med Biol. 2012. PMID: 22903675 Free PMC article. Review.
The ability of IgG-IC to capture dimeric C3b by the Fab portion is dependent on an affinity for C3 within the Fab portion, but outside the antigen-binding region. ...Both types of complexes, C3b2-IgG-IC and C3b2-F(ab')2-IC/anti-hinge NAbs, are potent precursors of alternat …
The ability of IgG-IC to capture dimeric C3b by the Fab portion is dependent on an affinity for C3 within the Fab portion, but outsid …
New approaches to the treatment of dense deposit disease.
Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF; Dense Deposit Disease Focus Group. Smith RJ, et al. J Am Soc Nephrol. 2007 Sep;18(9):2447-56. doi: 10.1681/ASN.2007030356. Epub 2007 Aug 5. J Am Soc Nephrol. 2007. PMID: 17675665 Free PMC article. Review.
A secondary criterion should be normalization of activity levels of the alternative complement pathway as measured by C3/C3d ratios and C3NeF levels. Outcomes should be reported to a central repository that is now accessible to all clinicians. ...
A secondary criterion should be normalization of activity levels of the alternative complement pathway as measured by C3/C3d ratios a …
Homoleptic Fe(III) and Fe(IV) Complexes of a Dianionic C3-Symmetric Scorpionate.
Tretiakov S, Lutz M, Titus CJ, de Groot F, Nehrkorn J, Lohmiller T, Holldack K, Schnegg A, Tarrago MFX, Zhang P, Ye S, Aleshin D, Pavlov A, Novikov V, Moret ME. Tretiakov S, et al. Inorg Chem. 2023 Jul 10;62(27):10613-10625. doi: 10.1021/acs.inorgchem.3c00871. Epub 2023 Jun 27. Inorg Chem. 2023. PMID: 37369076 Free PMC article.
Band 3/complement-mediated recognition and removal of normally senescent and pathological human erythrocytes.
Arese P, Turrini F, Schwarzer E. Arese P, et al. Cell Physiol Biochem. 2005;16(4-6):133-46. doi: 10.1159/000089839. Cell Physiol Biochem. 2005. PMID: 16301814 Free article. Review.
It is shown how specific oxidative as well as non-oxidative band 3 modifications enhance RBC membrane affinity for normally circulating anti-band 3 antibodies, and how membrane-bound anti-band 3 antibodies bring about a limited complement activation and membrane deposition of com …
It is shown how specific oxidative as well as non-oxidative band 3 modifications enhance RBC membrane affinity for normally circulating anti …
Assembly and regulation of the complement amplification loop in blood: the role of C3b-C3b-IgG complexes.
Jelezarova E, Lutz HU. Jelezarova E, et al. Mol Immunol. 1999 Sep-Oct;36(13-14):837-42. doi: 10.1016/s0161-5890(99)00104-2. Mol Immunol. 1999. PMID: 10698337 Review.
Amplification of complement activation in blood and serum starts on multi-protein complexes that act as precursors of an alternative C3 convertase. Among these covalently linked C4b-, C3b-, and IgG-containing complexes C3b-C3b-IgG complexes represent the major species cont …
Amplification of complement activation in blood and serum starts on multi-protein complexes that act as precursors of an alternative C3
Epidemiology of human immunodeficiency virus-visceral leishmaniasis-co-infection.
Naufal Spir PR, Zampieri D'Andrea LA, Fonseca ES, Prestes-Carneiro LE. Naufal Spir PR, et al. J Microbiol Immunol Infect. 2016 Apr;49(2):295-9. doi: 10.1016/j.jmii.2013.05.002. Epub 2013 Jul 6. J Microbiol Immunol Infect. 2016. PMID: 23834783 Free article.
We describe the epidemiological aspects of the expanding infection of VL and a case report of an HIV-VL-co-infected child from the west region of Sao Paulo state. The patient was an AIDS-C3 with low levels of CD4, high viral load, severe diarrhea, oral and perineal candidi …
We describe the epidemiological aspects of the expanding infection of VL and a case report of an HIV-VL-co-infected child from the west regi …
74 results