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Evolution of resistance to Aurora kinase B inhibitors in leukaemia cells.
Failes TW, Mitic G, Abdel-Halim H, Po'uha ST, Liu M, Hibbs DE, Kavallaris M. Failes TW, et al. PLoS One. 2012;7(2):e30734. doi: 10.1371/journal.pone.0030734. Epub 2012 Feb 16. PLoS One. 2012. PMID: 22359551 Free PMC article.
Human T-cell acute lymphoblastic leukaemia cells, CCRF-CEM, were selected for resistance in 4 M ZM447439. CEM/AKB4 cells showed no cross-resistance to tubulin-targeted and DNA-damaging agents, but were hypersensitive to an Aurora kinase A inhibitor. ...Progression of resi …
Human T-cell acute lymphoblastic leukaemia cells, CCRF-CEM, were selected for resistance in 4 M ZM447439. CEM/AKB4 cells showed no c …
Exploring chromone-2-carboxamide derivatives for triple-negative breast cancer targeting EGFR, FGFR3, and VEGF pathways: Design, synthesis, and preclinical insights.
El-Gamil DS, Zaky MY, Maximous PM, Sharaky M, El-Dessouki AM, Riad NM, Shaaban S, Abdel-Halim M, Al-Karmalawy AA. El-Gamil DS, et al. Drug Dev Res. 2024 Aug;85(5):e22228. doi: 10.1002/ddr.22228. Drug Dev Res. 2024. PMID: 38952003
Moreover, compound 15 exerted cell cycle arrest at both the G0-G1 and G2-M phases. The in vivo efficacy of compound 15 as an antitumor agent was further investigated in female mice bearing Solid Ehrlich Carcinoma. ...
Moreover, compound 15 exerted cell cycle arrest at both the G0-G1 and G2-M phases. The in vivo efficacy of compound 15 as an antitumo …
Effect of solvent on absorption and fluorescence spectra of a typical fluorinated azo dye for its acidic and basic structures.
Abdel-Halim ST. Abdel-Halim ST. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Nov;82(1):253-9. doi: 10.1016/j.saa.2011.07.045. Epub 2011 Jul 23. Spectrochim Acta A Mol Biomol Spectrosc. 2011. PMID: 21820950
The effect of 15 polar solvents on absorption and fluorescence energies of a typical fluorinated azo dye, 4-(2,3,5,6-tetrafluoro-pyridin-4-yl azo)-phenol, was reported for its acidic, MH, and basic, M, structures. For MH, the absorption energy is described on the basis of …
The effect of 15 polar solvents on absorption and fluorescence energies of a typical fluorinated azo dye, 4-(2,3,5,6-tetrafluoro-pyridin-4-y …