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Year Number of Results
1986 1
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1999 2
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2008 2
2009 4
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2011 1
2012 4
2013 3
2014 2
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77 results

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Page 1
An expanded universe of cancer targets.
Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS; Cancer Target Discovery and Development Network. Hahn WC, et al. Cell. 2021 Mar 4;184(5):1142-1155. doi: 10.1016/j.cell.2021.02.020. Cell. 2021. PMID: 33667368 Free PMC article. Review.
DNA-encoded library-enabled discovery of proximity-inducing small molecules.
Mason JW, Chow YT, Hudson L, Tutter A, Michaud G, Westphal MV, Shu W, Ma X, Tan ZY, Coley CW, Clemons PA, Bonazzi S, Berst F, Briner K, Liu S, Zécri FJ, Schreiber SL. Mason JW, et al. Nat Chem Biol. 2024 Feb;20(2):170-179. doi: 10.1038/s41589-023-01458-4. Epub 2023 Nov 2. Nat Chem Biol. 2024. PMID: 37919549 Free PMC article.
YTHDF2: a key RNA reader and antitumor target.
Xiao S, Duan S, Caligiuri MA, Ma S, Yu J. Xiao S, et al. Trends Immunol. 2025 Jun;46(6):485-498. doi: 10.1016/j.it.2025.04.003. Epub 2025 May 20. Trends Immunol. 2025. PMID: 40399203 Review.
N(6)-methyladenosine (m(6)A) is a key mRNA modification influencing mRNA stability and translation. YTHDF2, a major m(6)A 'reader', was initially recognized for promoting mRNA decay but is now also known to enhance translation by binding to methylated mRNAs. ...
N(6)-methyladenosine (m(6)A) is a key mRNA modification influencing mRNA stability and translation. YTHDF2, a major m(6)A 'rea …
Mapping the landscape of genetic dependencies in chordoma.
Sharifnia T, Wawer MJ, Goodale A, Lee Y, Kazachkova M, Dempster JM, Muller S, Levy J, Freed DM, Sommer J, Kalfon J, Vazquez F, Hahn WC, Root DE, Clemons PA, Schreiber SL. Sharifnia T, et al. Nat Commun. 2023 Apr 6;14(1):1933. doi: 10.1038/s41467-023-37593-8. Nat Commun. 2023. PMID: 37024492 Free PMC article.
Loss of YTHDF2 enhances Th9 programming and CAR-Th9 cell antitumor efficacy.
Xiao S, Duan S, Hong Y, Zhang J, Ma S, Caligiuri MA, Yu J. Xiao S, et al. Nat Immunol. 2025 Sep;26(9):1501-1515. doi: 10.1038/s41590-025-02235-2. Epub 2025 Aug 18. Nat Immunol. 2025. PMID: 40826275 Free PMC article.
However, the role of RNA N(6)-methyladenosine (m(6)A) modification in this differentiation is unclear. Here we show that YTHDF2, an important m(6)A reader protein known to destabilize m(6)A-modified mRNA, negatively regulates Th9 cell differentiation. ...
However, the role of RNA N(6)-methyladenosine (m(6)A) modification in this differentiation is unclear. Here we show that YTHDF2, an i …
A Streamlined Telepresent Video Platform for Aerospace Medicine.
Beer JMA, Ng PC, Wlodarski DC, Tompkins J, Mock J, Mojica A, Clemons M. Beer JMA, et al. Aerosp Med Hum Perform. 2025 Nov;96(11):1008-1014. doi: 10.3357/AMHP.6687.2025. Aerosp Med Hum Perform. 2025. PMID: 41253366
Beer JMA, Ng PC, Wlodarski DC, Tompkins J, Mock J, Mojica A, Clemons M. A streamlined telepresent video platform for aerospace medicine. Aerosp Med Hum Perform. 2025; 96(11):1008-1014....
Beer JMA, Ng PC, Wlodarski DC, Tompkins J, Mock J, Mojica A, Clemons M. A streamlined telepresent video platform for aerospace …
Metformin, insulin, breast cancer and more..
Berstein LM. Berstein LM. Future Oncol. 2009 Apr;5(3):309-12. doi: 10.2217/fon.09.2. Future Oncol. 2009. PMID: 19374538
EVALUATION OF: Goodwin PJ, Pritchard KI, Ennis M, Clemons M, Graham M, Fantus IG: Insulin-lowering effects of metformin in women with early breast cancer. ...
EVALUATION OF: Goodwin PJ, Pritchard KI, Ennis M, Clemons M, Graham M, Fantus IG: Insulin-lowering effects of me …
Diversity-oriented synthesis encoded by deoxyoligonucleotides.
Hudson L, Mason JW, Westphal MV, Richter MJR, Thielman JR, Hua BK, Gerry CJ, Xia G, Osswald HL, Knapp JM, Tan ZY, Kokkonda P, Tresco BIC, Liu S, Reidenbach AG, Lim KS, Poirier J, Capece J, Bonazzi S, Gampe CM, Smith NJ, Bradner JE, Coley CW, Clemons PA, Melillo B, Hon CS, Ottl J, Dumelin CE, Schaefer JV, Faust AME, Berst F, Schreiber SL, Zécri FJ, Briner K. Hudson L, et al. Nat Commun. 2023 Aug 15;14(1):4930. doi: 10.1038/s41467-023-40575-5. Nat Commun. 2023. PMID: 37582753 Free PMC article.
Similar compounds searching system by using the gene expression microarray database.
Toyoshiba H, Sawada H, Naeshiro I, Horinouchi A. Toyoshiba H, et al. Toxicol Lett. 2009 Apr 10;186(1):52-7. doi: 10.1016/j.toxlet.2008.08.009. Epub 2008 Aug 29. Toxicol Lett. 2009. PMID: 18801419
[Lamb, J., Crawford, E.D., Peck, D., Modell, J.W., Blat, I.C., Wrobel, M.J., Lerner, J., Brunet, J.P., Subramanian, A., Ross, K.N., Reich, M., Hieronymus, H., Wei, G., Armstrong, S.A., Haggarty, S.J., Clemons, P.A., Wei, R., Carr, S.A., Lander, E.S., Golub, T …
[Lamb, J., Crawford, E.D., Peck, D., Modell, J.W., Blat, I.C., Wrobel, M.J., Lerner, J., Brunet, J.P., Subramanian, A., Ross, K.N., R …
77 results