Targeted anticancer potential against glioma cells of thymoquinone delivered by mesoporous silica core-shell nanoformulations with pH-dependent release.
Shahein SA, Aboul-Enein AM, Higazy IM, Abou-Elella F, Lojkowski W, Ahmed ER, Mousa SA, AbouAitah K.
Shahein SA, et al.
Int J Nanomedicine. 2019 Jul 19;14:5503-5526. doi: 10.2147/IJN.S206899. eCollection 2019.
Int J Nanomedicine. 2019.
PMID: 31410001
Free PMC article.
The core-shell nanoformulations significantly improved caspase-3 activation, cytochrome c triggers, cell cycle arrest at G2/M, and apoptosis induction compared to TQ. CONCLUSION: Use of MSNs loaded with TQ permit improved cancer targeting and opens the door to translating …
The core-shell nanoformulations significantly improved caspase-3 activation, cytochrome c triggers, cell cycle arrest at G2/M, and ap …