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Discoidin domain receptor 1 activation links extracellular matrix to podocyte lipotoxicity in Alport syndrome.
Kim JJ, David JM, Wilbon SS, Santos JV, Patel DM, Ahmad A, Mitrofanova A, Liu X, Mallela SK, Ducasa GM, Ge M, Sloan AJ, Al-Ali H, Boulina M, Mendez AJ, Contreras GN, Prunotto M, Sohail A, Fridman R, Miner JH, Merscher S, Fornoni A. Kim JJ, et al. EBioMedicine. 2021 Jan;63:103162. doi: 10.1016/j.ebiom.2020.103162. Epub 2020 Dec 16. EBioMedicine. 2021. PMID: 33340991 Free PMC article.
Nonsegmented Negative-Sense RNA Viruses Utilize N (6)-Methyladenosine (m(6)A) as a Common Strategy To Evade Host Innate Immunity.
Lu M, Xue M, Wang HT, Kairis EL, Ahmad S, Wei J, Zhang Z, Liu Q, Zhang Y, Gao Y, Garcin D, Peeples ME, Sharma A, Hur S, He C, Li J. Lu M, et al. J Virol. 2021 Apr 12;95(9):e01939-20. doi: 10.1128/JVI.01939-20. Print 2021 Apr 12. J Virol. 2021. PMID: 33536170 Free PMC article.
As obligate intracellular parasites, many viruses acquire m(6)A methylation in their RNAs. However, the biological functions of viral m(6)A methylation are poorly understood. ...Viral RNA lacking m(6)A methylation induces a significantly higher type I interfe …
As obligate intracellular parasites, many viruses acquire m(6)A methylation in their RNAs. However, the biological functions of viral …
Plasma protein(s)-based conceptual diagnostic tool for assessing high-altitude acclimation in humans.
Paul S, Gangwar A, Bhargava K, Khan N, Khurana P, Ahmad Y. Paul S, et al. Funct Integr Genomics. 2020 Mar;20(2):191-200. doi: 10.1007/s10142-019-00712-0. Epub 2019 Aug 24. Funct Integr Genomics. 2020. PMID: 31444657
Exposure to high altitude above 3000 m leads to two outcomes-acclimation or high-altitude maladies. ...In this study, we investigate and statistically evaluate the trendlines of various hypoxia-responsive plasma protein levels, reported significantly perturbed in our previ …
Exposure to high altitude above 3000 m leads to two outcomes-acclimation or high-altitude maladies. ...In this study, we investigate …
Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate.
Ahmad S, Wright KN, Sun X, Groban L, Ferrario CM. Ahmad S, et al. Biochem Biophys Res Commun. 2019 Oct 22;518(4):651-656. doi: 10.1016/j.bbrc.2019.08.098. Epub 2019 Aug 26. Biochem Biophys Res Commun. 2019. PMID: 31466718 Free PMC article.
In the presence of both (CPA + rhChymase), small amounts of Ang-(1-9) and Ang-(1-7) were generated from (125)I-hAng-(1-12). The K(m) and V(max) values were 150 5 muM and 384 23 nM/min/mg of CPA and 40 9 muM and 116 20 nM/min/mg of rhChymase. The catalytic efficiency (V(max …
In the presence of both (CPA + rhChymase), small amounts of Ang-(1-9) and Ang-(1-7) were generated from (125)I-hAng-(1-12). The K(m) …
Molecular docking, DFT and antimicrobial studies of Cu(II) complex as topoisomerase I inhibitor.
Parveen S, Arjmand F, Zhang Q, Ahmad M, Khan A, Toupet L. Parveen S, et al. J Biomol Struct Dyn. 2021 Apr;39(6):2092-2105. doi: 10.1080/07391102.2020.1743365. Epub 2020 Mar 25. J Biomol Struct Dyn. 2021. PMID: 32174234
The intrinsic bonding constant value, K(b) was calculated to be 4.36 10(4) and 8.78 10(4) M(-1) with CT DNA and tRNA respectively. DNA cleavage activity was carried out with a pBR322 plasmid DNA substrate to ascertain the cleaving ability. Furthermore, Topo-I inhibition as …
The intrinsic bonding constant value, K(b) was calculated to be 4.36 10(4) and 8.78 10(4) M(-1) with CT DNA and tRNA respectively. DN …
Barrier protective effect of asiatic acid in TNF-α-induced activation of human aortic endothelial cells.
Fong LY, Ng CT, Cheok ZL, Mohd Moklas MA, Hakim MN, Ahmad Z. Fong LY, et al. Phytomedicine. 2016 Feb 15;23(2):191-9. doi: 10.1016/j.phymed.2015.11.019. Epub 2016 Jan 5. Phytomedicine. 2016. PMID: 26926181 Free article.
For other assays, HAECs were pretreated with various doses of asiatic acid (10-40 M) for 6 h followed by stimulation with TNF-alpha (10 ng/ml) for 6 h. ...
For other assays, HAECs were pretreated with various doses of asiatic acid (10-40 M) for 6 h followed by stimulation with TNF-alpha ( …
(13)C, (31)P and (15)N NMR studies of the ligand exchange reactions of auranofin and chloro(triethylphosphine)gold(I) with thiourea.
Ahmad S, Isab AA. Ahmad S, et al. J Inorg Biochem. 2002 Jan 1;88(1):44-52. doi: 10.1016/s0162-0134(01)00305-1. J Inorg Biochem. 2002. PMID: 11750024
However, some of the displaced Et(3)P is oxidized to Et(3)PO while the remaining reacts with Tu to form Et(3)P-Tu species, characterized by delta 31P of 1.0 ppm, assigned after an independent reaction between Et(3)P and Tu. In an experiment using a 0.05 M solution of auran …
However, some of the displaced Et(3)P is oxidized to Et(3)PO while the remaining reacts with Tu to form Et(3)P-Tu species, characterized by …
Gustatory receptor neurons in Manduca sexta contain a TrpA1-dependent signaling pathway that integrates taste and temperature.
Afroz A, Howlett N, Shukla A, Ahmad F, Batista E, Bedard K, Payne S, Morton B, Mansfield JH, Glendinning JI. Afroz A, et al. Chem Senses. 2013 Sep;38(7):605-17. doi: 10.1093/chemse/bjt032. Epub 2013 Jul 4. Chem Senses. 2013. PMID: 23828906 Free PMC article.
Next, we asked whether TrpA1 mediates the thermally dependent taste response to AA. To this end, we 1) identified a TrpA1 gene in M. sexta; 2) demonstrated expression of TrpA1 in the lateral and medial styloconic sensilla; 3) determined that 2 TrpA1 antagonists (HC-030031 …
Next, we asked whether TrpA1 mediates the thermally dependent taste response to AA. To this end, we 1) identified a TrpA1 gene in M. …
13 results