Tumor Necrosis Factor-alpha affects melanocyte survival and melanin synthesis via multiple pathways in vitiligo.
Singh M, Mansuri MS, Kadam A, Palit SP, Dwivedi M, Laddha NC, Begum R.
Singh M, et al.
Cytokine. 2021 Apr;140:155432. doi: 10.1016/j.cyto.2021.155432. Epub 2021 Jan 28.
Cytokine. 2021.
PMID: 33517195
Moreover, we observed a reduction in melanin content via shedding of dendrites, down-regulation of MITF-M, TYR and up-regulation of TNFR1, IL6, ICAM1 expression, whereas TNFR2 levels remain unaltered. ...
Moreover, we observed a reduction in melanin content via shedding of dendrites, down-regulation of MITF-M, TYR and up-regulation of T …