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Page 1
Treatment of Multisystem Inflammatory Syndrome in Children.
McArdle AJ, Vito O, Patel H, Seaby EG, Shah P, Wilson C, Broderick C, Nijman R, Tremoulet AH, Munblit D, Ulloa-Gutierrez R, Carter MJ, De T, Hoggart C, Whittaker E, Herberg JA, Kaforou M, Cunnington AJ, Levin M; BATS Consortium. McArdle AJ, et al. N Engl J Med. 2021 Jul 1;385(1):11-22. doi: 10.1056/NEJMoa2102968. Epub 2021 Jun 16. N Engl J Med. 2021. PMID: 34133854 Free PMC article.
CONCLUSIONS: We found no evidence that recovery from MIS-C differed after primary treatment with IVIG alone, IVIG plus glucocorticoids, or glucocorticoids alone, although significant differences may emerge as more data accrue. (Funded by the European Union's Horizon 2020 P …
CONCLUSIONS: We found no evidence that recovery from MIS-C differed after primary treatment with IVIG alone, IVIG plus glucocorticoids, or g …
Development of (4-Phenylamino)quinazoline Alkylthiourea Derivatives as Novel NF-κB Inhibitors.
Darwish SS, Chen PJ, Hamed MM, Wagdy RA, Chen SH, Abadi AH, Abdel-Halim M, Hwang TL, Engel M. Darwish SS, et al. Pharmaceuticals (Basel). 2022 Jun 22;15(7):778. doi: 10.3390/ph15070778. Pharmaceuticals (Basel). 2022. PMID: 35890077 Free PMC article.
One of the best compounds, 19, strongly inhibited the production of IL-6 (IC(50) = 0.84 M) and, less potently, of TNFalpha (IC(50) = 4.0 M); in comparison, the reference compound, caffeic acid phenethyl ester (CAPE), showed IC(50)s of 1.1 and 11.4 M, r …
One of the best compounds, 19, strongly inhibited the production of IL-6 (IC(50) = 0.84 M) and, less potently, of TNFalpha (IC(50) = …
Synthesis of novel 1,2-diarylpyrazolidin-3-one-based compounds and their evaluation as broad spectrum antibacterial agents.
Mokbel SA, Fathalla RK, El-Sharkawy LY, Abadi AH, Engel M, Abdel-Halim M. Mokbel SA, et al. Bioorg Chem. 2020 Jun;99:103759. doi: 10.1016/j.bioorg.2020.103759. Epub 2020 Mar 14. Bioorg Chem. 2020. PMID: 32220665
The oxime derivative 24 exhibited promising antibacterial activity against E. coli TolC, B. subtilis and S. aureus with MIC values of 4, 10 and 20 g/mL, respectively. The new lead compound 24 was found to exhibit a weak dual inhibitory activity against both the E
The oxime derivative 24 exhibited promising antibacterial activity against E. coli TolC, B. subtilis and S. aureus with MIC va …
American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus.
Brunner HI, Holland MJ, Beresford MW, Ardoin SP, Appenzeller S, Silva CA, Flores F, Goilav B, Avar Aydin PO, Wenderfer SE, Levy DM, Ravelli A, Khubchandani R, Avcin T, Klein-Gitelman MS, Ruperto N, Feldman BM, Ying J; Paediatric Rheumatology International Trial Organisation and Pediatric Rheumatology Collaborative Study Group. Brunner HI, et al. Arthritis Care Res (Hoboken). 2019 May;71(5):579-590. doi: 10.1002/acr.23834. Arthritis Care Res (Hoboken). 2019. PMID: 30680946 Free PMC article.
Occupational stress and mental health among nurses in a medical intensive care unit of a general hospital in Bandar Abbas in 2013.
Tajvar A, Saraji GN, Ghanbarnejad A, Omidi L, Hosseini SS, Abadi AS. Tajvar A, et al. Electron Physician. 2015 Jul 20;7(3):1108-13. doi: 10.14661/2015.1108-1113. eCollection 2015 Jul. Electron Physician. 2015. PMID: 26388976 Free PMC article.
Seventy-two nurses were selected as the population for this study, and all of them were female. Two questionnaires were used in this study, i.e., General Health Questionnaire-28 (GHQ-28) for assessing mental health and an occupational stress test for assessing job stress. …
Seventy-two nurses were selected as the population for this study, and all of them were female. Two questionnaires were used in this study, …