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Showing results for M. S. tavazoie
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HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events.
Alarcón CR, Goodarzi H, Lee H, Liu X, Tavazoie S, Tavazoie SF. Alarcón CR, et al. Cell. 2015 Sep 10;162(6):1299-308. doi: 10.1016/j.cell.2015.08.011. Epub 2015 Aug 27. Cell. 2015. PMID: 26321680 Free PMC article.
We find that the RNA-binding protein HNRNPA2B1 binds m(6)A-bearing RNAs in vivo and in vitro and its biochemical footprint matches the m(6)A consensus motif. ...We propose HNRNPA2B1 to be a nuclear reader of the m(6)A mark and to mediate, in part, this mark' …
We find that the RNA-binding protein HNRNPA2B1 binds m(6)A-bearing RNAs in vivo and in vitro and its biochemical footprint matches th …
mSphere of Influence: How the single cell contributes to the collective.
Lewin GR. Lewin GR. mSphere. 2025 Jan 28;10(1):e0043124. doi: 10.1128/msphere.00431-24. Epub 2024 Dec 11. mSphere. 2025. PMID: 39660837 Free PMC article.
In this mSphere of Influence article, she reflects on how two papers describing bacterial single-cell RNA-seq-"Prokaryotic single-cell RNA sequencing by in situ combinatorial indexing" by S. B. Blattman, W. Jiang, P. Oikonomou, and S. Tavazoie (Nat Microbiol …
In this mSphere of Influence article, she reflects on how two papers describing bacterial single-cell RNA-seq-"Prokaryotic single-cell RNA s …
[Prediction of transcription and genomic sequences].
Martin D, Ghattas B, Thieffry D. Martin D, et al. Med Sci (Paris). 2004 Nov;20(11):1036-40. doi: 10.1051/medsci/200420111036. Med Sci (Paris). 2004. PMID: 15525501 Free article. Review. French.
On the basis of the resulting sequences, computational biologists now attempt to localise the most important functional regions, starting with genes, but also importantly the regulatory motifs and conditions controlling their expression. In a recent paper published in Cell, M …
On the basis of the resulting sequences, computational biologists now attempt to localise the most important functional regions, starting wi …
Learning module networks from genome-wide location and expression data.
Xu X, Wang L, Ding D. Xu X, et al. FEBS Lett. 2004 Dec 17;578(3):297-304. doi: 10.1016/j.febslet.2004.11.019. FEBS Lett. 2004. PMID: 15589836 Free article.
We develop a systematic algorithm for discovering network of regulatory modules, which identifies regulatory modules and their regulation program by integrating genome-wide location and expression data. Unlike previous approaches [Eisen, M.B., Spellman, P.T., Brown, P.O. a …
We develop a systematic algorithm for discovering network of regulatory modules, which identifies regulatory modules and their regulation pr …
N6-methyladenosine marks primary microRNAs for processing.
Alarcón CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF. Alarcón CR, et al. Nature. 2015 Mar 26;519(7544):482-5. doi: 10.1038/nature14281. Epub 2015 Mar 18. Nature. 2015. PMID: 25799998 Free PMC article.
In vitro processing reactions confirmed the sufficiency of the N(6)-methyladenosine (m(6)A) mark in promoting pri-miRNA processing. Finally, gain-of-function experiments revealed that METTL3 is sufficient to enhance miRNA maturation in a global and non-cell-type-specific m …
In vitro processing reactions confirmed the sufficiency of the N(6)-methyladenosine (m(6)A) mark in promoting pri-miRNA processing. F …
let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts.
Legesse-Miller A, Elemento O, Pfau SJ, Forman JJ, Tavazoie S, Coller HA. Legesse-Miller A, et al. J Biol Chem. 2009 Mar 13;284(11):6605-9. doi: 10.1074/jbc.C900002200. Epub 2009 Jan 6. J Biol Chem. 2009. PMID: 19126550 Free PMC article.
We hypothesized that low Cdc34 levels would result in decreased SCF activity, stabilization of the SCF target Wee1, and G(2)/M accumulation. Consistent with this hypothesis, small interfering RNA-mediated down-regulation of Wee1 reversed the G(2)/M phenotype induced …
We hypothesized that low Cdc34 levels would result in decreased SCF activity, stabilization of the SCF target Wee1, and G(2)/M accumu …