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Page 1
Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators.
Botelho HM, Lopes-Pacheco M, Pinto MC, Railean V, Pankonien I, Caleiro MF, Clarke LA, Cachatra V, Neumann B, Tischer C, Moiteiro C, Ousingsawat J, Kunzelmann K, Pepperkok R, Amaral MD. Botelho HM, et al. Among authors: pinto mc. iScience. 2025 Feb 1;28(3):111942. doi: 10.1016/j.isci.2025.111942. eCollection 2025 Mar 21. iScience. 2025. PMID: 40040803 Free PMC article.
CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.
Lim SH, Snider J, Birimberg-Schwartz L, Ip W, Serralha JC, Botelho HM, Lopes-Pacheco M, Pinto MC, Moutaoufik MT, Zilocchi M, Laselva O, Esmaeili M, Kotlyar M, Lyakisheva A, Tang P, López Vázquez L, Akula I, Aboualizadeh F, Wong V, Grozavu I, Opacak-Bernardi T, Yao Z, Mendoza M, Babu M, Jurisica I, Gonska T, Bear CE, Amaral MD, Stagljar I. Lim SH, et al. Among authors: pinto mc. Mol Syst Biol. 2022 Feb;18(2):e10629. doi: 10.15252/msb.202110629. Mol Syst Biol. 2022. PMID: 35156780 Free PMC article.
Synergy in Cystic Fibrosis Therapies: Targeting SLC26A9.
Pinto MC, Quaresma MC, Silva IAL, Railean V, Ramalho SS, Amaral MD. Pinto MC, et al. Int J Mol Sci. 2021 Dec 2;22(23):13064. doi: 10.3390/ijms222313064. Int J Mol Sci. 2021. PMID: 34884866 Free PMC article.
Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids.
Rodenburg LW, Delpiano L, Railean V, Centeio R, Pinto MC, Smits SMA, van der Windt IS, van Hugten CFJ, van Beuningen SFB, Rodenburg RNP, van der Ent CK, Amaral MD, Kunzelmann K, Gray MA, Beekman JM, Amatngalim GD. Rodenburg LW, et al. Among authors: pinto mc. Int J Mol Sci. 2022 Oct 21;23(20):12657. doi: 10.3390/ijms232012657. Int J Mol Sci. 2022. PMID: 36293514 Free PMC article.
A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic.
Lérias JR, Pinto MC, Botelho HM, Awatade NT, Quaresma MC, Silva IAL, Wanitchakool P, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD. Lérias JR, et al. Among authors: pinto mc. Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):421-431. doi: 10.1016/j.bbamcr.2017.11.009. Epub 2017 Nov 15. Biochim Biophys Acta Mol Cell Res. 2018. PMID: 29154949 Free article.