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Discovery of New 1,3,4-Oxadiazoles with Dual Activity Targeting the Cholinergic Pathway as Effective Anti-Alzheimer Agents.
Elghazawy NH, Zaafar D, Hassan RR, Mahmoud MY, Bedda L, Bakr AF, Arafa RK. Elghazawy NH, et al. ACS Chem Neurosci. 2022 Apr 20;13(8):1187-1205. doi: 10.1021/acschemneuro.1c00766. Epub 2022 Apr 4. ACS Chem Neurosci. 2022. PMID: 35377601
Our synthesized compounds displayed excellent in vitro enzyme inhibitory activity at nanomolar (nM) concentrations against two major AD disease-modifying targets, i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among our compounds, 5e was considered th …
Our synthesized compounds displayed excellent in vitro enzyme inhibitory activity at nanomolar (nM) concentrations against two major AD dise …
Impact of Acrylic and Silicone-Based Soft-Liner Materials on Biting Force and Quality of Life of the Complete Denture Wearers: A Randomized Clinical Trial.
Alqutaibi AY, Alnazzawi AA, Farghal AE, Bakr RM, Mahmoud II. Alqutaibi AY, et al. J Clin Med. 2023 Mar 6;12(5):2073. doi: 10.3390/jcm12052073. J Clin Med. 2023. PMID: 36902859 Free PMC article.
The finding showed that both treatment modalities significantly improved the OHRQoL of included patients at one-month and three-month periods compared to baseline records (i.e., dentures before relining) with a statistically significant difference (p < 0.05). ...
The finding showed that both treatment modalities significantly improved the OHRQoL of included patients at one-month and three-month period …
Cytogenetic study of the effect of Schistosoma mansoni infection on human peripheral blood lymphocytes and the role of beta-carotene and vitamin E in modulating this effect.
Khaled IA, El-Ansary MS, Saleh AF, Mahmoud OM, Baioumi EA, Bakr HA. Khaled IA, et al. Mol Biol Rep. 2011 Aug;38(6):4101-9. doi: 10.1007/s11033-010-0530-3. Epub 2010 Nov 24. Mol Biol Rep. 2011. PMID: 21107709
Lymphocyte cultures of S. mansoni patients treated with 10 mug/ml beta-carotene or 20 mg/ml vitamin E showed a significant decrease in the percentage of structural chromosomal aberrations and the frequency of SCEs. ...Furthermore, higher doses of antioxidant drugs, beta-ca …
Lymphocyte cultures of S. mansoni patients treated with 10 mug/ml beta-carotene or 20 mg/ml vitamin E showed a significant decrease i …