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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1873 1
1881 2
1894 1
1945 3
1946 5
1947 6
1948 12
1949 7
1950 9
1951 26
1952 21
1953 14
1954 23
1955 9
1956 30
1957 18
1958 16
1959 7
1960 2
1961 9
1962 3
1963 14
1964 34
1965 25
1966 32
1967 24
1968 31
1969 40
1970 46
1971 38
1972 44
1973 29
1974 36
1975 63
1976 38
1977 41
1978 60
1979 57
1980 71
1981 58
1982 61
1983 61
1984 71
1985 55
1986 51
1987 62
1988 49
1989 63
1990 98
1991 62
1992 74
1993 69
1994 39
1995 47
1996 62
1997 54
1998 64
1999 59
2000 68
2001 72
2002 79
2003 77
2004 81
2005 86
2006 77
2007 87
2008 112
2009 99
2010 135
2011 120
2012 134
2013 184
2014 159
2015 185
2016 165
2017 175
2018 173
2019 198
2020 211
2021 232
2022 17
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4,695 results
Results by year
Filters applied: . Clear all The following term was not found in PubMed: Goteman
Page 1
Malin regulates Wnt signaling pathway through degradation of dishevelled2.
Sharma J, Mulherkar S, Mukherjee D, Jana NR. Sharma J, et al. J Biol Chem. 2012 Feb 24;287(9):6830-9. doi: 10.1074/jbc.M111.315135. Epub 2012 Jan 5. J Biol Chem. 2012. PMID: 22223637 Free PMC article.
Partial knockdown of malin significantly increases the level of dishevelled2 and up-regulates Wnt signaling. Several malin mutants are found to be ineffective in degrading dishevelled2 and regulating the Wnt pathway. ...
Partial knockdown of malin significantly increases the level of dishevelled2 and up-regulates Wnt signaling. Several malin mut …
Lafora disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level.
Romá-Mateo C, Moreno D, Vernia S, Rubio T, Bridges TM, Gentry MS, Sanz P. Romá-Mateo C, et al. BMC Evol Biol. 2011 Jul 28;11:225. doi: 10.1186/1471-2148-11-225. BMC Evol Biol. 2011. PMID: 21798009 Free PMC article.
In order to perform its function, malin forms a functional complex with laforin, a glucan phosphatase that facilitates targeting of malin to its corresponding substrates. ...However, TRIM32-specific substrates were not reciprocally ubiquitinated by the laforin-ma
In order to perform its function, malin forms a functional complex with laforin, a glucan phosphatase that facilitates targeting of …
Regulation of the autophagic PI3KC3 complex by laforin/malin E3-ubiquitin ligase, two proteins involved in Lafora disease.
Sanchez-Martin P, Lahuerta M, Viana R, Knecht E, Sanz P. Sanchez-Martin P, et al. Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118613. doi: 10.1016/j.bbamcr.2019.118613. Epub 2019 Nov 21. Biochim Biophys Acta Mol Cell Res. 2020. PMID: 31758957 Free PMC article.
Mutations in at least two genes are responsible for the disease: EPM2A, encoding the glucan phosphatase laforin, and EPM2B, encoding the RING-type E3-ubiquitin ligase malin. Both laforin and malin form a functional complex in which laforin recruits the substrates to …
Mutations in at least two genes are responsible for the disease: EPM2A, encoding the glucan phosphatase laforin, and EPM2B, encoding the RIN …
Endocytosis of the glutamate transporter 1 is regulated by laforin and malin: Implications in Lafora disease.
Perez-Jimenez E, Viana R, Muñoz-Ballester C, Vendrell-Tornero C, Moll-Diaz R, Garcia-Gimeno MA, Sanz P. Perez-Jimenez E, et al. Glia. 2021 May;69(5):1170-1183. doi: 10.1002/glia.23956. Epub 2020 Dec 23. Glia. 2021. PMID: 33368637 Free PMC article.
The disease is caused by mutations in EPM2A or EPM2B genes, which encode laforin, a glucan phosphatase, and malin, an E3-ubiquitin ligase, respectively. Although the exact roles of laforin and malin are still not well understood, it is known that they work as a comp …
The disease is caused by mutations in EPM2A or EPM2B genes, which encode laforin, a glucan phosphatase, and malin, an E3-ubiquitin li …
Lafora disease proteins laforin and malin negatively regulate the HIPK2-p53 cell death pathway.
Upadhyay M, Gupta S, Bhadauriya P, Ganesh S. Upadhyay M, et al. Biochem Biophys Res Commun. 2015 Aug 14;464(1):106-11. doi: 10.1016/j.bbrc.2015.06.018. Epub 2015 Jun 21. Biochem Biophys Res Commun. 2015. PMID: 26102034
LD is caused by defects in either the laforin protein phosphatase or the malin E3 ubiquitin ligase. Laforin and malin were shown play key roles in proteolytic processes, unfolded stress response, and glycogen metabolism. ...Overexpression of laforin or malin
LD is caused by defects in either the laforin protein phosphatase or the malin E3 ubiquitin ligase. Laforin and malin were sho …
Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models.
Upadhyay M, Agarwal S, Bhadauriya P, Ganesh S. Upadhyay M, et al. Neurobiol Dis. 2017 Apr;100:39-51. doi: 10.1016/j.nbd.2017.01.002. Epub 2017 Jan 4. Neurobiol Dis. 2017. PMID: 28063983
However, whether or not such neurodegenerative changes are a direct effect of the loss of laforin/malin was not unequivocally established. Here, we show that laforin- or malin-deficient neurons and fibroblasts display a significantly higher number of fragmented mito …
However, whether or not such neurodegenerative changes are a direct effect of the loss of laforin/malin was not unequivocally establi …
Loss of malin, but not laforin, results in compromised autophagic flux and proteasomal dysfunction in cells exposed to heat shock.
Jain N, Rai A, Mishra R, Ganesh S. Jain N, et al. Cell Stress Chaperones. 2017 Mar;22(2):307-315. doi: 10.1007/s12192-016-0754-9. Epub 2016 Dec 14. Cell Stress Chaperones. 2017. PMID: 27975203 Free PMC article.
Loss of malin leads to reduced proteasomal activity in the heat-shocked cells. Taken together, our results suggest a distinct mode of action for laforin and malin in the heat shock-induced proteolytic processes....
Loss of malin leads to reduced proteasomal activity in the heat-shocked cells. Taken together, our results suggest a distinct mode of …
Lafora Disease: A Ubiquitination-Related Pathology.
García-Gimeno MA, Knecht E, Sanz P. García-Gimeno MA, et al. Cells. 2018 Jul 26;7(8):87. doi: 10.3390/cells7080087. Cells. 2018. PMID: 30050012 Free PMC article. Review.
LD is caused by mutations in the EPM2A gene, encoding the dual phosphatase laforin, or the EPM2B gene, encoding the E3-ubiquitin ligase malin. Laforin and malin form a functional complex that is involved in the regulation of glycogen synthesis. ...In this work we re …
LD is caused by mutations in the EPM2A gene, encoding the dual phosphatase laforin, or the EPM2B gene, encoding the E3-ubiquitin ligase m
Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin.
Gentry MS, Worby CA, Dixon JE. Gentry MS, et al. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8501-6. doi: 10.1073/pnas.0503285102. Epub 2005 Jun 1. Proc Natl Acad Sci U S A. 2005. PMID: 15930137 Free PMC article.
Additionally, malin interacts with and polyubiquitinates laforin, leading to its degradation. ...Our results demonstrate that laforin is a physiologic substrate of malin, and we propose possible models to explain how recessive mutations in either malin or laf …
Additionally, malin interacts with and polyubiquitinates laforin, leading to its degradation. ...Our results demonstrate that laforin …
4,695 results