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Adenosine deaminase activity in COPD patients and healthy subjects.
Goodarzi MT, Abdi M, Tavilani H, Nadi E, Rashidi M. Goodarzi MT, et al. Iran J Allergy Asthma Immunol. 2010 Mar;9(1):7-12. Iran J Allergy Asthma Immunol. 2010. PMID: 20548128 Free article.
COPD consists of emphysema which is the destruction and inflammation of the lung alveoli. Adenosine deaminase (ADA, E.C.3.5.4.4) converts adenosine to inosine. There are two isoenzymes of ADA in serum; ADA1 and ADA2. It has been established that in COPD patients the …
COPD consists of emphysema which is the destruction and inflammation of the lung alveoli. Adenosine deaminase (ADA, E.C.3.5.4.4) conv …
The SAGA/TREX-2 subunit Sus1 binds widely to transcribed genes and affects mRNA turnover globally.
García-Molinero V, García-Martínez J, Reja R, Furió-Tarí P, Antúnez O, Vinayachandran V, Conesa A, Pugh BF, Pérez-Ortín JE, Rodríguez-Navarro S. García-Molinero V, et al. Epigenetics Chromatin. 2018 Mar 29;11(1):13. doi: 10.1186/s13072-018-0184-2. Epigenetics Chromatin. 2018. PMID: 29598828 Free PMC article.
BACKGROUND: Eukaryotic transcription is regulated through two complexes, the general transcription factor IID (TFIID) and the coactivator Spt-Ada-Gcn5 acetyltransferase (SAGA). Recent findings confirm that both TFIID and SAGA contribute to the synthesis of nearly all trans …
BACKGROUND: Eukaryotic transcription is regulated through two complexes, the general transcription factor IID (TFIID) and the coactivator Sp …
Adenosine A2A Receptors Are Upregulated in Peripheral Blood Mononuclear Cells from Atrial Fibrillation Patients.
Godoy-Marín H, Duroux R, Jacobson KA, Soler C, Colino-Lage H, Jiménez-Sábado V, Montiel J, Hove-Madsen L, Ciruela F. Godoy-Marín H, et al. Int J Mol Sci. 2021 Mar 27;22(7):3467. doi: 10.3390/ijms22073467. Int J Mol Sci. 2021. PMID: 33801676 Free PMC article.
In addition, plasma adenosine content and adenosine deaminase (ADA) activity in these subjects were also determined. Our results revealed increased A2AR expression in the right atrium from AF patients, as previously described. Interestingly, increased levels of adenosine c …
In addition, plasma adenosine content and adenosine deaminase (ADA) activity in these subjects were also determined. Our results reve …
Pharmacokinetics and tissue distribution of eighteen major alkaloids of Aconitum carmichaelii in rats by UHPLC-QQQ-MS.
Zhang Y, Zong X, Wu JL, Liu Y, Liu Z, Zhou H, Liu L, Li N. Zhang Y, et al. J Pharm Biomed Anal. 2020 Jun 5;185:113226. doi: 10.1016/j.jpba.2020.113226. Epub 2020 Mar 3. J Pharm Biomed Anal. 2020. PMID: 32163851
To systematically understand the pharmacokinetics (PK) and tissue distribution of A. carmichaelii, 18 representative alkaloids, including 8 amine- (ADA), 4 monoester- (MDA) and 6 diester-type (DDA) diterpenoid alkaloids, were simultaneously quantified by ultra-high perform …
To systematically understand the pharmacokinetics (PK) and tissue distribution of A. carmichaelii, 18 representative alkaloids, including 8 …
Enzymes of the purine metabolism in rat brain microsomes.
Franco R, Canela EI, Bozal J. Franco R, et al. Neurochem Res. 1986 Mar;11(3):407-22. doi: 10.1007/BF00965015. Neurochem Res. 1986. PMID: 3084983
Rat brain microsomes, when they are suspended in moderate ionic strength medium, released enzyme activities of lactate dehydrogenase (LDH, E.C.1.1.1.27), malate dehydrogenase (MDH, E.C.1.1.1.37), adenosine deaminase (ADA, E.C.3.5.4.4), guanine deaminase (GAH, E.C.3.5.4.3), …
Rat brain microsomes, when they are suspended in moderate ionic strength medium, released enzyme activities of lactate dehydrogenase (LDH, E …
Treatment of experimental autoimmune encephalomyelitis with adenylate deaminase from Penicillium lanoso-viride.
Nikolajeva V, Eze D, Petrina Z, Muiznieks I. Nikolajeva V, et al. J Autoimmun. 2000 Mar;14(2):107-13. doi: 10.1006/jaut.1999.0358. J Autoimmun. 2000. PMID: 10677241
A decrease in the number of morbid and dead animals was observed. Of ADA treated animals, 50-80% developed no clinical manifestations of EAE. ...The mechanism of ADA cerebroprotective action is discussed. Significant skin-allergic cross-reaction of delayed-type hype …
A decrease in the number of morbid and dead animals was observed. Of ADA treated animals, 50-80% developed no clinical manifestations …
Cocrystals of 6-methyl-2-thiouracil: presence of the acceptor-donor-acceptor/donor-acceptor-donor synthon.
Hützler WM, Egert E. Hützler WM, et al. Acta Crystallogr C Struct Chem. 2015 Mar;71(Pt 3):229-38. doi: 10.1107/S2053229615002867. Epub 2015 Feb 20. Acta Crystallogr C Struct Chem. 2015. PMID: 25734855
The results of seven cocrystallization experiments of the antithyroid drug 6-methyl-2-thiouracil (MTU), C(5)H(6)N(2)OS, with 2,4-diaminopyrimidine, 2,4,6-triaminopyrimidine and 6-amino-3H-isocytosine (viz. 2,6-diamino-3H-pyrimidin-4-one) are reported. MTU features an ADA ( …
The results of seven cocrystallization experiments of the antithyroid drug 6-methyl-2-thiouracil (MTU), C(5)H(6)N(2)OS, with 2,4-diaminopyri …
Heterogeneous localization of some purine enzymes in subcellular fractions of rat brain and cerebellum.
Franco R, Canela EI, Bozal J. Franco R, et al. Neurochem Res. 1986 Mar;11(3):423-35. doi: 10.1007/BF00965016. Neurochem Res. 1986. PMID: 3010150
The activity of guanine deaminase (GAH, E.C.3.5.4.3) was lower in rat cerebellum soluble and microsomal fractions than in rat brain subfractions. Adenosine deaminase (ADA, E.C.3.5.4.4) activity was released in higher proportion than guanine deaminase, purine nucleoside pho …
The activity of guanine deaminase (GAH, E.C.3.5.4.3) was lower in rat cerebellum soluble and microsomal fractions than in rat brain subfract …