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Page 1
N-acetyl-phenylalanine induces hepatic steatosis in MASLD by disrupting ER-mitochondria calcium coupling and mitochondrial lipid oxidation.
Lefebvre R, Rousseaux T, Bendridi N, Chanon S, Arquier D, Humbert A, Bertocchini N, Pillot B, Meugnier E, Vieille-Marchiset A, Nawrot M, Pinteur C, Ayciriex S, Loomba R, Rieusset J, Caussy C. Lefebvre R, et al. Among authors: nawrot m. bioRxiv [Preprint]. 2025 Sep 26:2025.09.24.678188. doi: 10.1101/2025.09.24.678188. bioRxiv. 2025. PMID: 41040284 Free PMC article. Preprint.
Endoplasmic reticulum-mitochondria contact sites are signalling hubs connecting nutrient sensing and GLP-1 secretion in L cells of the mouse gut: from physiology to obesity and type 2 diabetes.
Humbert A, Nawrot M, Bendridi N, Gouriou Y, Bertocchini N, Chauvin MA, Ji-Cao J, Durand C, Vieille-Marchiset A, Pinteur C, Morio B, Reimann F, Guerci B, Ravier MA, Lestavel S, Rieusset J. Humbert A, et al. Among authors: nawrot m. Diabetologia. 2026 Jul;69(7):2044-2060. doi: 10.1007/s00125-026-06693-7. Epub 2026 Mar 8. Diabetologia. 2026. PMID: 41795036 Free PMC article.
Intestinal FXR deficiency uncouples steatosis protection from liver inflammation and fibrosis in MASH-diet fed mice.
Nawrot M, Peschard S, Thibaut MM, Ory K, Vallez E, Dorchies E, Touche V, Dubois-Chevalier J, Gheeraert C, Caron S, Bantubungi K, Lefebvre P, Tailleux A, Haas JT, Bindels LB, Leclercq I, Dombrowicz D, Lestavel S, Staels B. Nawrot M, et al. Sci Rep. 2026 Jul 10. doi: 10.1038/s41598-026-60976-y. Online ahead of print. Sci Rep. 2026. PMID: 42431962 Free article.
The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids.
Ducastel S, Touche V, Trabelsi MS, Boulinguiez A, Butruille L, Nawrot M, Peschard S, Chávez-Talavera O, Dorchies E, Vallez E, Annicotte JS, Lancel S, Briand O, Bantubungi K, Caron S, Bindels LB, Delzenne NM, Tailleux A, Staels B, Lestavel S. Ducastel S, et al. Among authors: nawrot m. Sci Rep. 2020 Jan 13;10(1):174. doi: 10.1038/s41598-019-56743-x. Sci Rep. 2020. PMID: 31932631 Free PMC article.