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2016 2
2018 1
2019 5
2020 1
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Page 1
DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters.
Sutton MN, Lu Z, Li YC, Zhou Y, Huang T, Reger AS, Hurwitz AM, Palzkill T, Logsdon C, Liang X, Gray JW, Nan X, Hancock J, Wahl GM, Bast RC Jr. Sutton MN, et al. Cell Rep. 2019 Dec 10;29(11):3448-3459.e6. doi: 10.1016/j.celrep.2019.11.045. Cell Rep. 2019. PMID: 31825828 Free PMC article.
RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells.
Sutton MN, Yang H, Huang GY, Fu C, Pontikos M, Wang Y, Mao W, Pang L, Yang M, Liu J, Parker-Thornburg J, Lu Z, Bast RC Jr. Sutton MN, et al. Autophagy. 2018;14(4):637-653. doi: 10.1080/15548627.2018.1427022. Epub 2018 Mar 21. Autophagy. 2018. PMID: 29368982 Free PMC article.
DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1.
Sutton MN, Huang GY, Liang X, Sharma R, Reger AS, Mao W, Pang L, Rask PJ, Lee K, Gray JP, Hurwitz AM, Palzkill T, Millward SW, Kim C, Lu Z, Bast RC Jr. Sutton MN, et al. Cancers (Basel). 2019 Apr 18;11(4):557. doi: 10.3390/cancers11040557. Cancers (Basel). 2019. PMID: 31003488 Free PMC article.
Amino Acid Deprivation-Induced Autophagy Requires Upregulation of DIRAS3 through Reduction of E2F1 and E2F4 Transcriptional Repression.
Sutton MN, Huang GY, Zhou J, Mao W, Langley R, Lu Z, Bast RC Jr. Sutton MN, et al. Cancers (Basel). 2019 Apr 30;11(5):603. doi: 10.3390/cancers11050603. Cancers (Basel). 2019. PMID: 31052266 Free PMC article.
The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3-induced dormant ovarian cancer xenografts.
Mao W, Peters HL, Sutton MN, Orozco AF, Pang L, Yang H, Lu Z, Bast RC Jr. Mao W, et al. Among authors: sutton mn. Cancer. 2019 Apr 15;125(8):1267-1280. doi: 10.1002/cncr.31935. Epub 2019 Jan 8. Cancer. 2019. PMID: 30620384 Free PMC article.
Complementary Longitudinal Serum Biomarkers to CA125 for Early Detection of Ovarian Cancer.
Simmons AR, Fourkala EO, Gentry-Maharaj A, Ryan A, Sutton MN, Baggerly K, Zheng H, Lu KH, Jacobs I, Skates S, Menon U, Bast RC Jr. Simmons AR, et al. Among authors: sutton mn. Cancer Prev Res (Phila). 2019 Jun;12(6):391-400. doi: 10.1158/1940-6207.CAPR-18-0377. Epub 2019 Apr 9. Cancer Prev Res (Phila). 2019. PMID: 30967390 Free PMC article.
Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders.
Li YC, Lytle NK, Gammon ST, Wang L, Hayes TK, Sutton MN, Bast RC Jr, Der CJ, Piwnica-Worms D, McCormick F, Wahl GM. Li YC, et al. Among authors: sutton mn. Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12121-12130. doi: 10.1073/pnas.2000848117. Epub 2020 May 18. Proc Natl Acad Sci U S A. 2020. PMID: 32424096
Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB.
Morgado M, Sutton MN, Simmons M, Warren CR, Lu Z, Constantinou PE, Liu J, Francis LL, Conlan RS, Bast RC Jr, Carson DD. Morgado M, et al. Among authors: sutton mn. Oncotarget. 2016 Mar 22;7(12):14871-84. doi: 10.18632/oncotarget.7652. Oncotarget. 2016. PMID: 26918940 Free PMC article.
Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models.
Ornelas A, McCullough CR, Lu Z, Zacharias NM, Kelderhouse LE, Gray J, Yang H, Engel BJ, Wang Y, Mao W, Sutton MN, Bhattacharya PK, Bast RC Jr, Millward SW. Ornelas A, et al. Among authors: sutton mn. BMC Cancer. 2016 Oct 26;16(1):824. doi: 10.1186/s12885-016-2850-8. BMC Cancer. 2016. PMID: 27784287 Free PMC article.
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