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Page 1
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt Adrian J, Calvopiña K, Turrientes MC, Kavanagh ME, Lubriks D, Hinchliffe P, Langley GW, Aboklaish AF, Eneroth A, Backlund M, Baran AG, Nielsen EI, Speake M, Kuka J, Robinson J, Grinberga S, Robinson L, McDonough MA, Rydzik AM, Leissing TM, Jimenez-Castellanos JC, Avison MB, Da Silva Pinto S, Pannifer AD, Martjuga M, Widlake E, Priede M, Hopkins Navratilova I, Gniadkowski M, Belfrage AK, Brandt P, Yli-Kauhaluoma J, Bacque E, Page MGP, Björkling F, Tyrrell JM, Spencer J, Lang PA, Baranczewski P, Cantón R, McElroy SP, Jones PS, Baquero F, Suna E, Morrison A, Walsh TR, Schofield CJ. Brem J, et al. Among authors: backlund m. Nat Chem. 2022 Jan;14(1):15-24. doi: 10.1038/s41557-021-00831-x. Epub 2021 Dec 13. Nat Chem. 2022. PMID: 34903857
N-(Heteroaryl)thiophene sulfonamides as angiotensin AT2 receptor ligands.
Wannberg J, Gising J, Henriksson M, Vo DD, Sävmarker J, Sallander J, Gutiérrez-de-Terán H, Larsson J, Hamid S, Ablahad H, Spizzo I, Gaspari TA, Widdop RE, Grönbladh A, Petersen NN, Backlund M, Hallberg M, Larhed M. Wannberg J, et al. Among authors: backlund m. Eur J Med Chem. 2024 Feb 5;265:116122. doi: 10.1016/j.ejmech.2024.116122. Epub 2024 Jan 3. Eur J Med Chem. 2024. PMID: 38199164 Free article.
N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands.
Wannberg J, Gising J, Lindman J, Salander J, Gutiérrez-de-Terán H, Ablahad H, Hamid S, Grönbladh A, Spizzo I, Gaspari TA, Widdop RE, Hallberg A, Backlund M, Leśniak A, Hallberg M, Larhed M. Wannberg J, et al. Among authors: backlund m. Bioorg Med Chem. 2021 Jan 1;29:115859. doi: 10.1016/j.bmc.2020.115859. Epub 2020 Nov 7. Bioorg Med Chem. 2021. PMID: 33309749
Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.
Huseby DL, Cao S, Zamaratski E, Sooriyaarachchi S, Ahmad S, Bergfors T, Krasnova L, Pelss J, Ikaunieks M, Loza E, Katkevics M, Bobileva O, Cirule H, Gukalova B, Grinberga S, Backlund M, Simoff I, Leber AT, Berruga-Fernández T, Antonov D, Konda VR, Lindström S, Olanders G, Brandt P, Baranczewski P, Vingsbo Lundberg C, Liepinsh E, Suna E, Jones TA, Mowbray SL, Hughes D, Karlén A. Huseby DL, et al. Among authors: backlund m. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2317274121. doi: 10.1073/pnas.2317274121. Epub 2024 Apr 5. Proc Natl Acad Sci U S A. 2024. PMID: 38579010 Free PMC article.
Neuroprotective and Disease-Modifying Effects of the Triazinetrione ACD856, a Positive Allosteric Modulator of Trk-Receptors for the Treatment of Cognitive Dysfunction in Alzheimer's Disease.
Parrado Fernandez C, Juric S, Backlund M, Dahlström M, Madjid N, Lidell V, Rasti A, Sandin J, Nordvall G, Forsell P. Parrado Fernandez C, et al. Among authors: backlund m. Int J Mol Sci. 2023 Jul 6;24(13):11159. doi: 10.3390/ijms241311159. Int J Mol Sci. 2023. PMID: 37446337 Free PMC article.
Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.
Sou T, Hansen J, Liepinsh E, Backlund M, Ercan O, Grinberga S, Cao S, Giachou P, Petersson A, Tomczak M, Urbas M, Zabicka D, Vingsbo Lundberg C, Hughes D, Hobbie SN, Friberg LE. Sou T, et al. Among authors: backlund m. Clin Pharmacol Ther. 2021 Apr;109(4):1063-1073. doi: 10.1002/cpt.2104. Epub 2020 Nov 28. Clin Pharmacol Ther. 2021. PMID: 33150591 Free PMC article.
17 results