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Activation of the Nrf2 response by oleanolic acid oxime morpholide (3-hydroxyiminoolean-12-en-28-oic acid morpholide) is associated with its ability to induce apoptosis and inhibit proliferation in HepG2 hepatoma cells.
Narożna M, Krajka-Kuźniak V, Kleszcz R, Bednarczyk-Cwynar B, Szaefer H, Baer-Dubowska W. Narożna M, et al. Eur J Pharmacol. 2020 Sep 15;883:173307. doi: 10.1016/j.ejphar.2020.173307. Epub 2020 Jul 12. Eur J Pharmacol. 2020. PMID: 32668287
Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential.
Narożna M, Krajka-Kuźniak V, Bednarczyk-Cwynar B, Kucińska M, Kleszcz R, Kujawski J, Piotrowska-Kempisty H, Plewiński A, Murias M, Baer-Dubowska W. Narożna M, et al. Pharmaceuticals (Basel). 2021 Jul 17;14(7):688. doi: 10.3390/ph14070688. Pharmaceuticals (Basel). 2021. PMID: 34358114 Free PMC article.