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Analysis of Histone Modifications by Mass Spectrometry.
Völker-Albert MC, Schmidt A, Forne I, Imhof A. Völker-Albert MC, et al. Curr Protoc Protein Sci. 2018 Apr;92(1):e54. doi: 10.1002/cpps.54. Curr Protoc Protein Sci. 2018. PMID: 30040183
Histone N termini undergo diverse post-translational modifications that significantly extend the information potential of the genetic code. Moreover, these modifications mark specific chromatin regions, modulating epigenetic control, lineage commitment, and overall functio …
Histone N termini undergo diverse post-translational modifications that significantly extend the information potential of the genetic code. …
GSNOR Contributes to Demethylation and Expression of Transposable Elements and Stress-Responsive Genes.
Rudolf EE, Hüther P, Forné I, Georgii E, Han Y, Hell R, Wirtz M, Imhof A, Becker C, Durner J, Lindermayr C. Rudolf EE, et al. Antioxidants (Basel). 2021 Jul 15;10(7):1128. doi: 10.3390/antiox10071128. Antioxidants (Basel). 2021. PMID: 34356361 Free PMC article.
We propose that GSNOR1 activity affects chromatin accessibility by controlling the transmethylation activity (MI) required for maintaining DNA methylation and the level of the repressive chromatin mark H3K9me2....
We propose that GSNOR1 activity affects chromatin accessibility by controlling the transmethylation activity (MI) required for maintaining D …
Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin.
Pellegrino S, Michelena J, Teloni F, Imhof R, Altmeyer M. Pellegrino S, et al. Cell Rep. 2017 May 30;19(9):1819-1831. doi: 10.1016/j.celrep.2017.05.016. Cell Rep. 2017. PMID: 28564601 Free PMC article.
Here, we show that the ability of 53BP1 to accumulate around DSBs declines as cells progress through S phase and reveal that the inverse relationship between 53BP1 recruitment and replicated chromatin is linked to the replication-coupled dilution of 53BP1's target mark H4K …
Here, we show that the ability of 53BP1 to accumulate around DSBs declines as cells progress through S phase and reveal that the inverse rel …
Methylation of histone H3 lysine 9 occurs during translation.
Rivera C, Saavedra F, Alvarez F, Díaz-Celis C, Ugalde V, Li J, Forné I, Gurard-Levin ZA, Almouzni G, Imhof A, Loyola A. Rivera C, et al. Nucleic Acids Res. 2015 Oct 30;43(19):9097-106. doi: 10.1093/nar/gkv929. Epub 2015 Sep 24. Nucleic Acids Res. 2015. PMID: 26405197 Free PMC article.
This includes methylation of lysine 9 on histone H3 (H3K9), a mark that primes the formation of heterochromatin, a critical chromatin landmark for genome stability. ...
This includes methylation of lysine 9 on histone H3 (H3K9), a mark that primes the formation of heterochromatin, a critical chromatin …
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.
Metzger E, Wang S, Urban S, Willmann D, Schmidt A, Offermann A, Allen A, Sum M, Obier N, Cottard F, Ulferts S, Preca BT, Hermann B, Maurer J, Greschik H, Hornung V, Einsle O, Perner S, Imhof A, Jung M, Schüle R. Metzger E, et al. Nat Struct Mol Biol. 2019 May;26(5):361-371. doi: 10.1038/s41594-019-0219-9. Epub 2019 May 6. Nat Struct Mol Biol. 2019. PMID: 31061526
C21orf127 functions as an obligate heterodimer with TRMT112, writing the methylation mark on lysine 12 of histone H4 (H4K12) in vitro and in vivo. We characterized H4K12 recognition by solving the crystal structure of human C21orf127-TRMT112, hereafter termed 'lysine methy …
C21orf127 functions as an obligate heterodimer with TRMT112, writing the methylation mark on lysine 12 of histone H4 (H4K12) in vitro …
Analysis of histone modifications by mass spectrometry.
Villar-Garea A, Israel L, Imhof A. Villar-Garea A, et al. Curr Protoc Protein Sci. 2008 Feb;Chapter 14:Unit 14.10. doi: 10.1002/0471140864.ps1410s51. Curr Protoc Protein Sci. 2008. PMID: 18429056
Histone N-termini undergo diverse post-translational modifications that significantly extend the information potential of the genetic code. Moreover, they appear to mark specific chromatin regions, modulating epigenetic control, lineage commitment, and overall function of …
Histone N-termini undergo diverse post-translational modifications that significantly extend the information potential of the genetic code. …
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.
Saredi G, Huang H, Hammond CM, Alabert C, Bekker-Jensen S, Forne I, Reverón-Gómez N, Foster BM, Mlejnkova L, Bartke T, Cejka P, Mailand N, Imhof A, Patel DJ, Groth A. Saredi G, et al. Nature. 2016 Jun 30;534(7609):714-718. doi: 10.1038/nature18312. Epub 2016 Jun 22. Nature. 2016. PMID: 27338793 Free PMC article.
We identify the TONSL ankyrin repeat domain (ARD) as a reader of histone H4 tails unmethylated at K20 (H4K20me0), which are specific to new histones incorporated during DNA replication and mark post-replicative chromatin until the G2/M phase of the cell cycle. ...
We identify the TONSL ankyrin repeat domain (ARD) as a reader of histone H4 tails unmethylated at K20 (H4K20me0), which are specific to new …
Recommendations for competency in allergy training for undergraduates qualifying as medical practitioners: a position paper of the world allergy organization.
Potter PC, Warner JO, Pawankar R, Kaliner MA, Del Giacco S, Rosenwasser L; WAO Specialty and Training Council. Potter PC, et al. World Allergy Organ J. 2009 Aug;2(8):150-4. doi: 10.1186/1939-4551-2-8-150. World Allergy Organ J. 2009. PMID: 23283109 Free PMC article.
The Council acknowledges specific comments from: The American Academy of Allergy, Asthma and Immunology (AAAAI) (Amal H Assa'ad); The American College of Allergy, Asthma and Immunology (ACAAI) (Mark Dykewicz, D. Betty Lew, Bryan L. Martin); The Argentine Association of All …
The Council acknowledges specific comments from: The American Academy of Allergy, Asthma and Immunology (AAAAI) (Amal H Assa'ad); The Americ …
Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits.
Brami-Cherrier K, Anzalone A, Ramos M, Forne I, Macciardi F, Imhof A, Borrelli E. Brami-Cherrier K, et al. Mol Psychiatry. 2014 Nov;19(11):1193-200. doi: 10.1038/mp.2014.67. Epub 2014 Jul 15. Mol Psychiatry. 2014. PMID: 25023144 Free PMC article.
Indeed, we observed a remarkable downregulation of gene expression in this area of ~2000 genes, which involves a widespread increase in the histone repressive mark H3K9me2/3. This reprogramming process is coupled to psychotic-like behaviors in the mutant mice. ...
Indeed, we observed a remarkable downregulation of gene expression in this area of ~2000 genes, which involves a widespread increase in the …
15 results