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17 results

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Page 1
Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.
England E, Rees DG, Scott IC, Carmen S, Chan DTY, Chaillan Huntington CE, Houslay KF, Erngren T, Penney M, Majithiya JB, Rapley L, Sims DA, Hollins C, Hinchy EC, Strain MD, Kemp BP, Corkill DJ, May RD, Vousden KA, Butler RJ, Mustelin T, Vaughan TJ, Lowe DC, Colley C, Cohen ES. England E, et al. Among authors: penney m. Sci Rep. 2023 Jun 17;13(1):9825. doi: 10.1038/s41598-023-36642-y. Sci Rep. 2023. PMID: 37330528 Free PMC article.
Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.
Nijsen MJMA, Wu F, Bansal L, Bradshaw-Pierce E, Chan JR, Liederer BM, Mettetal JT, Schroeder P, Schuck E, Tsai A, Xu C, Chimalakonda A, Le K, Penney M, Topp B, Yamada A, Spilker ME. Nijsen MJMA, et al. Among authors: penney m. CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):135-146. doi: 10.1002/psp4.12282. Epub 2018 Feb 1. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29349875 Free PMC article. Review.
Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-Cλ interface.
Bagert JD, Oganesyan V, Chiang CI, Iannotti M, Lin J, Yang C, Payne S, McMahon W, Edwards S, Dippel A, Hutchinson M, Huang F, Aleti V, Niu C, Qian C, Denham J, Ferreira S, Pradhan P, Penney M, Wang C, Liu W, Walseng E, Mazor Y. Bagert JD, et al. Among authors: penney m. MAbs. 2023 Jan-Dec;15(1):2273449. doi: 10.1080/19420862.2023.2273449. Epub 2023 Nov 6. MAbs. 2023. PMID: 37930310 Free PMC article.
A mechanistic PK/PD model of AZD0171 (anti-LIF) to support Phase II dose selection.
Shahraz A, Penney M, Candido J, Opoku-Ansah G, Neubauer M, Eyles J, Ojo O, Liu N, Luheshi NM, Phipps A, Vishwanathan K. Shahraz A, et al. Among authors: penney m. CPT Pharmacometrics Syst Pharmacol. 2024 Oct;13(10):1670-1681. doi: 10.1002/psp4.13204. Epub 2024 Jul 23. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 39041713 Free PMC article.
Structural and functional characterization of a specific antidote for ticagrelor.
Buchanan A, Newton P, Pehrsson S, Inghardt T, Antonsson T, Svensson P, Sjögren T, Öster L, Janefeldt A, Sandinge AS, Keyes F, Austin M, Spooner J, Gennemark P, Penney M, Howells G, Vaughan T, Nylander S. Buchanan A, et al. Among authors: penney m. Blood. 2015 May 28;125(22):3484-90. doi: 10.1182/blood-2015-01-622928. Epub 2015 Mar 18. Blood. 2015. PMID: 25788700 Free PMC article.
17 results