Evolution of STAT2 resistance to flavivirus NS5 occurred multiple times despite genetic constraints.
Veit EC, Salim MS, Jung MJ, Richardson RB, Boys IN, Quinlan M, Barrall EA, Bednarski E, Hamilton RE, Kikawa C, Elde NC, García-Sastre A, Evans MJ.
Veit EC, et al.
Nat Commun. 2024 Jun 26;15(1):5426. doi: 10.1038/s41467-024-49758-0.
Nat Commun. 2024.
PMID: 38926343
Free PMC article.
In four species, resistance requires distinct sets of multiple amino acid changes that often individually disrupt STAT2 signaling. This reflects an evolutionary ridge where progressive resistance is balanced by the need to maintain STAT2 function. ...
In four species, resistance requires distinct sets of multiple amino acid changes that often individually disrupt STAT2 signaling. This refl …