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Pharmacokinetic assessment of dapivirine vaginal microbicide gel in healthy, HIV-negative women.
Nel AM, Coplan P, Smythe SC, McCord K, Mitchnick M, Kaptur PE, Romano J. Nel AM, et al. AIDS Res Hum Retroviruses. 2010 Nov;26(11):1181-90. doi: 10.1089/aid.2009.0227. Epub 2010 Sep 21. AIDS Res Hum Retroviruses. 2010. PMID: 20854207 Clinical Trial.
Plasma concentrations of dapivirine increased over time with gel dose and were greater on Day 10 (C(max) 31 to 471 pg/ml) than Day 1 (C(max) 23 to 80 pg/ml). T(max) was 10-12 h on Day 1, and 9 h on Day 10. ...
Plasma concentrations of dapivirine increased over time with gel dose and were greater on Day 10 (C(max) 31 to 471 pg/ml) than Day 1 …
Uncoupling of the noradrenergic-hypothalamic-pituitary-adrenal axis in panic disorder patients.
Coplan JD, Pine D, Papp L, Martinez J, Cooper T, Rosenblum LA, Gorman JM. Coplan JD, et al. Neuropsychopharmacology. 1995 Aug;13(1):65-73. doi: 10.1016/0893-133X(95)00018-9. Neuropsychopharmacology. 1995. PMID: 8526972
Healthy volunteers exhibited multiple significant "couplings" between either baseline or maximal decrease (delta max) of plasma MHPG, with either baseline or delta max plasma cortisol measures both within the first and second challenges and between the first and sec …
Healthy volunteers exhibited multiple significant "couplings" between either baseline or maximal decrease (delta max) of plasma MHPG, …
Neuroendocrine predictors of response to intravenous clomipramine therapy for refractory obsessive-compulsive disorder.
Mathew SJ, Coplan JD, Perko KA, Goetz RR, de la Neuz M, Hollander E, Liebowitz MR, Fallon BA. Mathew SJ, et al. Depress Anxiety. 2001;14(4):199-208. doi: 10.1002/da.1067. Depress Anxiety. 2001. PMID: 11754126 Clinical Trial.
Response was assessed by the Clinical Global Impressions (CGI). Low PRL(MAX) to IV CMI and low cortisol levels overall on day 1 were both significantly associated with clinical response at day 14. ...
Response was assessed by the Clinical Global Impressions (CGI). Low PRL(MAX) to IV CMI and low cortisol levels overall on day 1 were …