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154 results

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Page 1
Artificial intelligence for natural product drug discovery.
Mullowney MW, Duncan KR, Elsayed SS, Garg N, van der Hooft JJJ, Martin NI, Meijer D, Terlouw BR, Biermann F, Blin K, Durairaj J, Gorostiola González M, Helfrich EJN, Huber F, Leopold-Messer S, Rajan K, de Rond T, van Santen JA, Sorokina M, Balunas MJ, Beniddir MA, van Bergeijk DA, Carroll LM, Clark CM, Clevert DA, Dejong CA, Du C, Ferrinho S, Grisoni F, Hofstetter A, Jespers W, Kalinina OV, Kautsar SA, Kim H, Leao TF, Masschelein J, Rees ER, Reher R, Reker D, Schwaller P, Segler M, Skinnider MA, Walker AS, Willighagen EL, Zdrazil B, Ziemert N, Goss RJM, Guyomard P, Volkamer A, Gerwick WH, Kim HU, Müller R, van Wezel GP, van Westen GJP, Hirsch AKH, Linington RG, Robinson SL, Medema MH. Mullowney MW, et al. Among authors: medema mh. Nat Rev Drug Discov. 2023 Nov;22(11):895-916. doi: 10.1038/s41573-023-00774-7. Epub 2023 Sep 11. Nat Rev Drug Discov. 2023. PMID: 37697042 Free article. Review.
Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome.
Chen L, Zhernakova DV, Kurilshikov A, Andreu-Sánchez S, Wang D, Augustijn HE, Vich Vila A; Lifelines Cohort Study; Weersma RK, Medema MH, Netea MG, Kuipers F, Wijmenga C, Zhernakova A, Fu J. Chen L, et al. Among authors: medema mh. Nat Med. 2022 Nov;28(11):2333-2343. doi: 10.1038/s41591-022-02014-8. Epub 2022 Oct 10. Nat Med. 2022. PMID: 36216932 Free PMC article.
A widely distributed gene cluster compensates for uricase loss in hominids.
Liu Y, Jarman JB, Low YS, Augustijn HE, Huang S, Chen H, DeFeo ME, Sekiba K, Hou BH, Meng X, Weakley AM, Cabrera AV, Zhou Z, van Wezel G, Medema MH, Ganesan C, Pao AC, Gombar S, Dodd D. Liu Y, et al. Among authors: medema mh. Cell. 2023 Aug 3;186(16):3400-3413.e20. doi: 10.1016/j.cell.2023.06.010. Cell. 2023. PMID: 37541197 Free PMC article.
A computational framework to explore large-scale biosynthetic diversity.
Navarro-Muñoz JC, Selem-Mojica N, Mullowney MW, Kautsar SA, Tryon JH, Parkinson EI, De Los Santos ELC, Yeong M, Cruz-Morales P, Abubucker S, Roeters A, Lokhorst W, Fernandez-Guerra A, Cappelini LTD, Goering AW, Thomson RJ, Metcalf WW, Kelleher NL, Barona-Gomez F, Medema MH. Navarro-Muñoz JC, et al. Among authors: medema mh. Nat Chem Biol. 2020 Jan;16(1):60-68. doi: 10.1038/s41589-019-0400-9. Epub 2019 Nov 25. Nat Chem Biol. 2020. PMID: 31768033 Free PMC article.
Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome.
Carrión VJ, Perez-Jaramillo J, Cordovez V, Tracanna V, de Hollander M, Ruiz-Buck D, Mendes LW, van Ijcken WFJ, Gomez-Exposito R, Elsayed SS, Mohanraju P, Arifah A, van der Oost J, Paulson JN, Mendes R, van Wezel GP, Medema MH, Raaijmakers JM. Carrión VJ, et al. Among authors: medema mh. Science. 2019 Nov 1;366(6465):606-612. doi: 10.1126/science.aaw9285. Science. 2019. PMID: 31672892
Genome mining strategies for metallophore discovery.
Reitz ZL, Medema MH. Reitz ZL, et al. Among authors: medema mh. Curr Opin Biotechnol. 2022 Oct;77:102757. doi: 10.1016/j.copbio.2022.102757. Epub 2022 Jul 30. Curr Opin Biotechnol. 2022. PMID: 35914390 Free article. Review.
A widely distributed gene cluster compensates for uricase loss in hominids.
Liu Y, Jarman JB, Low YS, Augustijn HE, Huang S, Chen H, DeFeo ME, Sekiba K, Hou BH, Meng X, Weakley AM, Cabrera AV, Zhou Z, van Wezel G, Medema MH, Ganesan C, Pao AC, Gombar S, Dodd D. Liu Y, et al. Among authors: medema mh. Cell. 2023 Sep 28;186(20):4472-4473. doi: 10.1016/j.cell.2023.08.036. Cell. 2023. PMID: 37774682 Free PMC article.
Road MAPs to engineer host microbiomes.
Oyserman BO, Medema MH, Raaijmakers JM. Oyserman BO, et al. Among authors: medema mh. Curr Opin Microbiol. 2018 Jun;43:46-54. doi: 10.1016/j.mib.2017.11.023. Epub 2017 Dec 5. Curr Opin Microbiol. 2018. PMID: 29207308 Free article. Review.
154 results