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Showing results for menten fu
Your search for Mengen Fu retrieved no results
Evaluation of 5-fluorouracil pharmacokinetic models and therapeutic drug monitoring in cancer patients.
van Kuilenburg AB, Maring JG. van Kuilenburg AB, et al. Pharmacogenomics. 2013 May;14(7):799-811. doi: 10.2217/pgs.13.54. Pharmacogenomics. 2013. PMID: 23651027 Review.
To date, compartmental Michaelis-Menten elimination-based modeling has proven to be a sensitive and accurate tool for analyzing the pharmacokinetics of 5-FU and to identify patients with a dihydropyrimidine dehydrogenase deficiency. These Michaelis-Menten mod …
To date, compartmental Michaelis-Menten elimination-based modeling has proven to be a sensitive and accurate tool for analyzing the p …
Enzyme-mimetic self-catalyzed polymerization of polypeptide helices.
Song Z, Fu H, Baumgartner R, Zhu L, Shih KC, Xia Y, Zheng X, Yin L, Chipot C, Lin Y, Cheng J. Song Z, et al. Nat Commun. 2019 Nov 29;10(1):5470. doi: 10.1038/s41467-019-13502-w. Nat Commun. 2019. PMID: 31784526 Free PMC article.
The reversible binding between the N terminus of alpha-helical polypeptides and NCAs promotes rate acceleration of the subsequent ring-opening reaction. A two-stage, Michaelis-Menten-type kinetic model is proposed by considering the binding and reaction between the propaga …
The reversible binding between the N terminus of alpha-helical polypeptides and NCAs promotes rate acceleration of the subsequent ring-openi …
Role of an Ice Surface in the Photoreaction of Coumarins.
Zhang S, Zhang C, Fu Y, Li L, Huang C, Lin Y, Zhu C, Francisco JS, He Z, Zhou X, Wang J. Zhang S, et al. Langmuir. 2022 Sep 20;38(37):11346-11353. doi: 10.1021/acs.langmuir.2c01637. Epub 2022 Sep 6. Langmuir. 2022. PMID: 36066243
We further reveal that the reaction rate is found to be proportional to the total area of the ice surface and follows Michaelis-Menten-like kinetics, indicating that the ice surface catalyzes the reaction. ...
We further reveal that the reaction rate is found to be proportional to the total area of the ice surface and follows Michaelis-Menten
Population Pharmacokinetic-Pharmacodynamic Modeling of 5-Fluorouracil for Toxicities in Rats.
Kobuchi S, Ito Y, Sakaeda T. Kobuchi S, et al. Eur J Drug Metab Pharmacokinet. 2017 Aug;42(4):707-718. doi: 10.1007/s13318-016-0389-3. Eur J Drug Metab Pharmacokinet. 2017. PMID: 27889876
RESULTS: The population pharmacokinetic model consisting of a two-compartment model with Michaelis-Menten elimination kinetics successfully characterized the individual and population predictions of the plasma concentration of 5-FU and provided credible parameter es …
RESULTS: The population pharmacokinetic model consisting of a two-compartment model with Michaelis-Menten elimination kinetics succes …
Kinetics of Enzymatic Reactions at the Solid/Liquid Interface in Nanofluidic Channels.
Yamamoto K, Morikawa K, Imanaka H, Imamura K, Kitamori T. Yamamoto K, et al. Anal Chem. 2022 Nov 15;94(45):15686-15694. doi: 10.1021/acs.analchem.2c02878. Epub 2022 Oct 31. Anal Chem. 2022. PMID: 36315424
Devices with channel depths of 300 nm, 4.4 mum, and 13.6 mum were fabricated. Kinetic parameters were determined by the Michaelis-Menten model. Compared to the bulk reaction, all k(cat)s for immobilized enzyme reactors were decreased, although the k(cat)s were approximatel …
Devices with channel depths of 300 nm, 4.4 mum, and 13.6 mum were fabricated. Kinetic parameters were determined by the Michaelis-Menten
Michaelis-Menten speeds up tau-leaping under a wide range of conditions.
Wu S, Fu J, Cao Y, Petzold L. Wu S, et al. J Chem Phys. 2011 Apr 7;134(13):134112. doi: 10.1063/1.3576123. J Chem Phys. 2011. PMID: 21476748 Free PMC article.
This paper examines the benefits of Michaelis-Menten model reduction techniques in stochastic tau-leaping simulations. ...
This paper examines the benefits of Michaelis-Menten model reduction techniques in stochastic tau-leaping simulations. ...
Nonlinear pharmacokinetics of 5-fluorouracil in rats.
Jarugula VR, Lam SS, Boudinot FD. Jarugula VR, et al. J Pharm Sci. 1997 Jun;86(6):756-8. doi: 10.1021/js960451a. J Pharm Sci. 1997. PMID: 9188061
The effects of dose on the pharmacokinetics of 5-fluorouracil (5-FU) were investigated following intravenous administration of 5-FU at 10, 50, and 100 mg/kg to adult male Sprague-Dawley rats. ...The lower nonrenal clearance following the 100-mg/kg dose compared with …
The effects of dose on the pharmacokinetics of 5-fluorouracil (5-FU) were investigated following intravenous administration of 5-F
Pharmacokinetic analysis of doxifluridine and its metabolites, 5-fluorouracil and 5-fluorouridine, after oral administration in beagle dogs.
Baek IH, Lee BY, Kim MS, Kwon KI. Baek IH, et al. Eur J Drug Metab Pharmacokinet. 2013 Dec;38(4):295-9. doi: 10.1007/s13318-013-0130-4. Epub 2013 Apr 7. Eur J Drug Metab Pharmacokinet. 2013. PMID: 23564503
After the administration of 200 mg of Furtulon to 23 beagle dogs, the plasma concentrations of doxifluridine, 5-FU, and 5-FUrd were measured simultaneously, using LC-MS/MS. The parent-metabolite compartment model with first-order absorption and Michaelis-Menten kine …
After the administration of 200 mg of Furtulon to 23 beagle dogs, the plasma concentrations of doxifluridine, 5-FU, and 5-FUrd were m …
Modeling and Designing Particle-Regulated Amyloid-like Assembly of Synthetic Polypeptides in Aqueous Solution.
Yang T, Benson K, Fu H, Xue T, Song Z, Duan H, Xia H, Kalluri A, He J, Cheng J, Kumar CV, Lin Y. Yang T, et al. Biomacromolecules. 2022 Jan 10;23(1):196-209. doi: 10.1021/acs.biomac.1c01230. Epub 2021 Dec 29. Biomacromolecules. 2022. PMID: 34964619
Amyloid-like fibrillation was supported by a variety of standard characterization methods. Nucleation followed a Michaelis-Menten-like scheme for the cationic silica NPCs, while the corresponding anionic or neutral nanoparticles had no effect on fibrillation. ...
Amyloid-like fibrillation was supported by a variety of standard characterization methods. Nucleation followed a Michaelis-Menten-lik …
Metal-Organic Frameworks-Based Immobilized Enzyme Microreactors Integrated with Capillary Electrochromatography for High-Efficiency Enzyme Assay.
Liu R, Yi G, Ji B, Liu X, Gui Y, Xia Z, Fu Q. Liu R, et al. Anal Chem. 2022 May 3;94(17):6540-6547. doi: 10.1021/acs.analchem.1c05586. Epub 2022 Apr 23. Anal Chem. 2022. PMID: 35465669
The excellent separation performance of the UiO-66-NH(2)-modified capillary was verified by high-efficiency separation of three types of neutral, acidic, and basic compounds. The Michaelis-Menten constant and enzyme inhibition kinetics of UiO-66-NH(2)-IMER were systematica …
The excellent separation performance of the UiO-66-NH(2)-modified capillary was verified by high-efficiency separation of three types of neu …
69 results