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1996 2
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15 results

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Page 1
A New C22-Quassinoid with Anti-Pancreatic Adenocarcinoma Activity from Seeds of Brucea javanica.
Yang CB, Lu SN, Lu C, Xu MM, Duan JA, Che CT, Zhou J, Zhao M. Yang CB, et al. Chem Biodivers. 2022 Jun;19(6):e202101004. doi: 10.1002/cbdv.202101004. Epub 2022 May 20. Chem Biodivers. 2022. PMID: 35514039
In addition, all isolates were evaluated for their anti-pancreatic adenocarcinoma activity by measuring the growth inhibitory of the MIA PaCa-2 cell lines. Consequently, compounds 1, 7-10, and 12-16 exhibited potent anti-pancreatic cancer activity in vitro (IC(50) =0.0540. …
In addition, all isolates were evaluated for their anti-pancreatic adenocarcinoma activity by measuring the growth inhibitory of the MIA …
Structurally diverse (9β-H)-pimarane derivatives with six frameworks from the leaves of Icacina oliviformis and their cytotoxic activities.
Xu M, Di D, Fan L, Ma Y, Wei X, Shang EX, Onakpa MM, Johnson OO, Duan JA, Che CT, Zhou J, Zhao M. Xu M, et al. Phytochemistry. 2023 Oct;214:113804. doi: 10.1016/j.phytochem.2023.113804. Epub 2023 Aug 2. Phytochemistry. 2023. PMID: 37541354
In cytotoxic bioassay, compound 2 exhibited significant cytotoxic against HT-29 with IC(50) values of 7.88 muM, even stronger than 5-fluorouracil, and 15 showed broad-spectrum cytotoxic activities against HepG2, HT-29, and MIA PaCa-2 with IC(50) values of 11.62, 9.77, and …
In cytotoxic bioassay, compound 2 exhibited significant cytotoxic against HT-29 with IC(50) values of 7.88 muM, even stronger than 5-fluorou …
High prevalence of vancomycin non-susceptible and multi-drug resistant enterococci in farmed animals and fresh retail meats in Bangladesh.
Samad MA, Sagor MS, Hossain MS, Karim MR, Mahmud MA, Sarker MS, Shownaw FA, Mia Z, Card RM, Agunos A, Johanna L. Samad MA, et al. Vet Res Commun. 2022 Sep;46(3):811-822. doi: 10.1007/s11259-022-09906-7. Epub 2022 Mar 26. Vet Res Commun. 2022. PMID: 35338457
Virulence factors such as gelatinase (gelE), aggregation factor (asa1) and sex pheromone (cpd) are detected along with vancomycin resistance gene (vanA, vanB and vanC2/C3) in VNSE isolates. The high prevalence of MDR enterococci in food animals and retail meats may cause c …
Virulence factors such as gelatinase (gelE), aggregation factor (asa1) and sex pheromone (cpd) are detected along with vancomycin resistance …
ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target.
Kimura K, Matsumoto S, Harada T, Morii E, Nagatomo I, Shintani Y, Kikuchi A. Kimura K, et al. Cancer Sci. 2020 Mar;111(3):951-961. doi: 10.1111/cas.14303. Epub 2020 Feb 22. Cancer Sci. 2020. PMID: 31925985 Free PMC article.
Lung adenocarcinoma is the most common histological type of lung cancer and is classified into adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IA). Atypical adenomatous hyperplasia (AAH) lesions are possible precursors to …
Lung adenocarcinoma is the most common histological type of lung cancer and is classified into adenocarcinoma in situ (AIS), minimally invas …
Design and synthesis of novel monoterpenoid indole alkaloid-like analogues and their antitumour activities in vitro.
Fang J, Huang T, Xia M, Deng L, Hao X, Wang Y, Mu S. Fang J, et al. Org Biomol Chem. 2018 Apr 25;16(16):3026-3037. doi: 10.1039/c8ob00677f. Org Biomol Chem. 2018. PMID: 29634066
A biomimetic synthetic strategy and combinatorial chemistry were used to synthesize 34 novel monoterpenoid indole alkaloid (MIA) analogues, and their cytotoxic activities against five cancer cell lines (SW-480, A-549, HL-60, SMMC-7721, and MCF-7) were determined using the …
A biomimetic synthetic strategy and combinatorial chemistry were used to synthesize 34 novel monoterpenoid indole alkaloid (MIA) anal …
Subclinical endometritis in dairy cattle is associated with distinct mRNA expression patterns in blood and endometrium.
Raliou M, Dembélé D, Düvel A, Bolifraud P, Aubert J, Mary-Huard T, Rocha D, Piumi F, Mockly S, Heppelmann M, Dieuzy-Labaye I, Zieger P, G E Smith D, Schuberth HJ, Sheldon IM, Sandra O. Raliou M, et al. PLoS One. 2019 Aug 2;14(8):e0220244. doi: 10.1371/journal.pone.0220244. eCollection 2019. PLoS One. 2019. PMID: 31374089 Free PMC article.
Nineteen differentially expressed genes associated with SCE were common to both circulating WBC and the endometrium. Among these genes, transcript abundance of immune factors C3, C2, LTF, PF4 and TRAPPC13 were up-regulated in SCE cows at 45-55 days postpartum. Moreover, mR …
Nineteen differentially expressed genes associated with SCE were common to both circulating WBC and the endometrium. Among these genes, tran …
Anti-inflammatory and analgesic activities of Neolamarckia cadamba and its bioactive monoterpenoid indole alkaloids.
Yuan HL, Zhao YL, Qin XJ, Liu YP, Yu HF, Zhu PF, Jin Q, Yang XW, Luo XD. Yuan HL, et al. J Ethnopharmacol. 2020 Oct 5;260:113103. doi: 10.1016/j.jep.2020.113103. Epub 2020 Jun 20. J Ethnopharmacol. 2020. PMID: 32569718
Subsequent phytochemical investigation of EA fraction led to the structural characterization of four new monoterpenoid indole alkaloids, neocadambines A-D (1-4), as well as eight known analogues (5-12). Neocadambine A possesses a novel 14-nor-MIA skeleton that could be der …
Subsequent phytochemical investigation of EA fraction led to the structural characterization of four new monoterpenoid indole alkaloids, neo …
Local secretion of complement C3 in the exocrine pancreas: ductal epithelial cells as a possible biosynthetic site.
Andoh A, Fujiyama Y, Sumiyoshi K, Bamba T. Andoh A, et al. Gastroenterology. 1996 Jun;110(6):1919-25. doi: 10.1053/gast.1996.v110.pm8964419. Gastroenterology. 1996. PMID: 8964419
METHODS: C3 protein in human pancreatic fluid was analyzed by, immunoblotting. ...C3 mRNA expression was observed in the ductal cell carcinoma lines (PANC-1 and MIA PaCa-2) but not in the acinar cell line (HPC-YO and AR-42J). ...
METHODS: C3 protein in human pancreatic fluid was analyzed by, immunoblotting. ...C3 mRNA expression was observed in the ducta …
CCN1 promotes tumorigenicity through Rac1/Akt/NF-κB signaling pathway in pancreatic cancer.
Wang X, Deng Y, Mao Z, Ma X, Fan X, Cui L, Qu J, Xie D, Zhang J. Wang X, et al. Tumour Biol. 2012 Oct;33(5):1745-58. doi: 10.1007/s13277-012-0434-z. Epub 2012 Jul 3. Tumour Biol. 2012. PMID: 22752926
Then we forced expression and silenced CCN1 expression in pancreatic cancer cell lines MIA PaCa2 and PANC-1 respectively, using lentivirus vectors. We characterized the stable cells in vitro and in vivo using a nude mouse xenograft model. ...Furthermore, we disclosed that …
Then we forced expression and silenced CCN1 expression in pancreatic cancer cell lines MIA PaCa2 and PANC-1 respectively, using lenti …
15 results