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The functional MICA-129 polymorphism is associated with skin but not joint manifestations of psoriatic disease independently of HLA-B and HLA-C.
Pollock RA, Chandran V, Pellett FJ, Thavaneswaran A, Eder L, Barrett J, Rahman P, Farewell V, Gladman DD. Pollock RA, et al. Tissue Antigens. 2013 Jul;82(1):43-7. doi: 10.1111/tan.12126. Epub 2013 Apr 24. Tissue Antigens. 2013. PMID: 23611695
A methionine/valine polymorphism at amino acid 129 of the major histocompatibility complex class I chain-related gene A (MICA-129) categorizes alleles into strong and weak binders of the natural killer (NK) and T-cell receptor NKG2D. ...No association remained after adjust …
A methionine/valine polymorphism at amino acid 129 of the major histocompatibility complex class I chain-related gene A (MICA-129) ca …
Differential major histocompatibility complex class I chain-related A allele associations with skin and joint manifestations of psoriatic disease.
Pollock R, Chandran V, Barrett J, Eder L, Pellett F, Yao C, Lino M, Shanmugarajah S, Farewell VT, Gladman DD. Pollock R, et al. Tissue Antigens. 2011 Jun;77(6):554-61. doi: 10.1111/j.1399-0039.2011.01670.x. Epub 2011 Apr 4. Tissue Antigens. 2011. PMID: 21457151
Here, we describe a case-control study that aims to validate previously reported MICA allele associations with PsA and determine whether MICA alleles differentiate patients with PsA from those with psoriasis without PsA. ...Independent of HLA, only MICA*016 i …
Here, we describe a case-control study that aims to validate previously reported MICA allele associations with PsA and determine whet …
Further Evidence Supporting a Parent-of-Origin Effect in Psoriatic Disease.
Pollock RA, Thavaneswaran A, Pellett F, Chandran V, Petronis A, Rahman P, Gladman DD. Pollock RA, et al. Arthritis Care Res (Hoboken). 2015 Nov;67(11):1586-90. doi: 10.1002/acr.22625. Arthritis Care Res (Hoboken). 2015. PMID: 26017758 Free article.
Newfoundland probands with paternally transmitted disease had higher HLA-B*08 carriage (P = 0.04) and lower MICA-129Met carriage (P = 0.03). Males had higher HLA-B*38 carriage (P = 0.05) and a higher prevalence of nail lesions (P = 0.01). ...
Newfoundland probands with paternally transmitted disease had higher HLA-B*08 carriage (P = 0.04) and lower MICA-129Met carriage (P = …
Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.
Okada Y, Han B, Tsoi LC, Stuart PE, Ellinghaus E, Tejasvi T, Chandran V, Pellett F, Pollock R, Bowcock AM, Krueger GG, Weichenthal M, Voorhees JJ, Rahman P, Gregersen PK, Franke A, Nair RP, Abecasis GR, Gladman DD, Elder JT, de Bakker PI, Raychaudhuri S. Okada Y, et al. Am J Hum Genet. 2014 Aug 7;95(2):162-72. doi: 10.1016/j.ajhg.2014.07.002. Epub 2014 Jul 31. Am J Hum Genet. 2014. PMID: 25087609 Free PMC article.
Here, we conducted a large-scale fine-mapping study of PsV risk in the MHC region in 9,247 PsV-affected individuals and 13,589 controls of European descent by imputing class I and II human leukocyte antigen (HLA) genes from SNP genotype data. In addition, we imputed sequence vari …
Here, we conducted a large-scale fine-mapping study of PsV risk in the MHC region in 9,247 PsV-affected individuals and 13,589 controls of E …