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A single dose of AC102 restores hearing in a guinea pig model of noise-induced hearing loss to almost prenoise levels.
Rommelspacher H, Bera S, Brommer B, Ward R, Kwiatkowska M, Zygmunt T, Theden F, Üsekes B, Eren N, Nieratschker M, Arnoldner C, Plontke SK, Hellmann-Regen J, Schlingensiepen R. Rommelspacher H, et al. Among authors: nieratschker m. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2314763121. doi: 10.1073/pnas.2314763121. Epub 2024 Apr 1. Proc Natl Acad Sci U S A. 2024. PMID: 38557194 Free PMC article.
A homozygous AP3D1 missense variant in patients with sensorineural hearing loss as the leading manifestation.
Frohne A, Koenighofer M, Cetin H, Nieratschker M, Liu DT, Laccone F, Neesen J, Nemec SF, Schwarz-Nemec U, Schoefer C, Avraham KB, Frei K, Grabmeier-Pfistershammer K, Kratzer B, Schmetterer K, Pickl WF, Parzefall T. Frohne A, et al. Among authors: nieratschker m. Hum Genet. 2023 Aug;142(8):1077-1089. doi: 10.1007/s00439-022-02506-0. Epub 2022 Nov 29. Hum Genet. 2023. PMID: 36445457 Free PMC article.
Single-incision cochlear implantation and hearing evaluation in piglets and minipigs.
Yildiz E, Gerlitz M, Gadenstaetter AJ, Landegger LD, Nieratschker M, Schum D, Schmied M, Haase A, Kanz F, Kramer AM, Glueckert R, Staecker H, Honeder C, Arnoldner C. Yildiz E, et al. Among authors: nieratschker m. Hear Res. 2022 Dec;426:108644. doi: 10.1016/j.heares.2022.108644. Epub 2022 Oct 31. Hear Res. 2022. PMID: 36343533 Free article.
A preoperative dose of the pyridoindole AC102 improves the recovery of residual hearing in a gerbil animal model of cochlear implantation.
Nieratschker M, Yildiz E, Gerlitz M, Bera S, Gadenstaetter AJ, Kramer AM, Kwiatkowska M, Mistrik P, Landegger LD, Braun S, Schlingensiepen R, Honeder C, Arnoldner C, Rommelspacher H. Nieratschker M, et al. Cell Death Dis. 2024 Jul 26;15(7):531. doi: 10.1038/s41419-024-06854-9. Cell Death Dis. 2024. PMID: 39060244 Free PMC article.
Investigation of inner ear drug delivery with a cochlear catheter in piglets as a representative model for human cochlear pharmacokinetics.
Yildiz E, Gadenstaetter AJ, Gerlitz M, Landegger LD, Liepins R, Nieratschker M, Glueckert R, Staecker H, Honeder C, Arnoldner C. Yildiz E, et al. Among authors: nieratschker m. Front Pharmacol. 2023 Mar 9;14:1062379. doi: 10.3389/fphar.2023.1062379. eCollection 2023. Front Pharmacol. 2023. PMID: 36969846 Free PMC article.
15 results