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Page 1
Aged mice exhibit widespread metabolic changes but preserved major fluxes.
Jankowski CSR, Samarah LZ, MacArthur MR, Mitchell SJ, Weilandt DR, Hunter CJ, Zeng X, McReynolds MR, Rabinowitz JD. Jankowski CSR, et al. Among authors: macarthur mr. Cell Metab. 2025 Nov 4;37(11):2280-2294.e4. doi: 10.1016/j.cmet.2025.09.009. Epub 2025 Oct 16. Cell Metab. 2025. PMID: 41106390
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis.
Lee WD, Weilandt DR, Liang L, MacArthur MR, Jaiswal N, Ong O, Mann CG, Chu Q, Hunter CJ, Ryseck RP, Lu W, Oschmann AM, Cowan AJ, TeSlaa TA, Bartman CR, Jang C, Baur JA, Titchenell PM, Rabinowitz JD. Lee WD, et al. Among authors: macarthur mr. Cell Metab. 2025 Mar 4;37(3):758-771.e8. doi: 10.1016/j.cmet.2024.12.009. Epub 2025 Jan 30. Cell Metab. 2025. PMID: 39889702 Free PMC article.
Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors.
Roichman A, Zuo Q, Hwang S, Lu W, Cordova RA, MacArthur MR, Boyer JA, Mitchell SJ, Powers J, Koval SA, Hunter CJ, Rijmers J, Ryseck RP, AbuSalim JE, Chatterjee S, Lee WD, Xu X, Xing X, Chen Z, Zeng X, Marwaha S, McBride MJ, Guo JY, Kang Y, Donia MS, Rabinowitz JD. Roichman A, et al. Among authors: macarthur mr. Cell. 2025 May 29;188(11):3065-3080.e21. doi: 10.1016/j.cell.2025.04.041. Epub 2025 May 19. Cell. 2025. PMID: 40393457
Spatial metabolic gradients in the liver and small intestine.
Samarah LZ, Zheng C, Xing X, Lee WD, Afriat A, Chitra U, MacArthur MR, Lu W, Jankowski CSR, Ma C, Hunter CJ, Neinast M, Weilandt DR, Raphael BJ, Rabinowitz JD. Samarah LZ, et al. Among authors: macarthur mr. Nature. 2025 Dec;648(8092):182-190. doi: 10.1038/s41586-025-09616-5. Epub 2025 Oct 15. Nature. 2025. PMID: 41094143 Free PMC article.
Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.
Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T. Langston PK, et al. Among authors: macarthur mr. Nat Immunol. 2019 Sep;20(9):1186-1195. doi: 10.1038/s41590-019-0453-7. Epub 2019 Aug 5. Nat Immunol. 2019. PMID: 31384058 Free PMC article.
Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice.
Trautman ME, Green CL, MacArthur MR, Chaiyakul K, Alam YH, Yeh CY, Babygirija R, James I, Gilpin M, Zelenovskiy E, Green M, Marshall RN, Raskin A, Sonsalla MM, Flores V, Simcox JA, Ong IM, Malecki KC, Jang C, Lamming DW. Trautman ME, et al. Among authors: macarthur mr. Mol Metab. 2025 Nov;101:102248. doi: 10.1016/j.molmet.2025.102248. Epub 2025 Sep 10. Mol Metab. 2025. PMID: 40939730 Free PMC article.
Host metabolism can produce many indoles and phenols independently of the microbiome.
AbuSalim JE, Olszewski K, Youssef S, Mitchell SJ, Hunter CJ, Little J, Sidebottom A, Boyer JA, Knutson SD, Samarah LZ, MacArthur MR, Henneberg AL, Ryseck RP, Opitz CA, MacMillan DWC, Donia MS, Pamer EG, Imam S, Lehmann CJ, Odenike O, Rabinowitz JD. AbuSalim JE, et al. Among authors: macarthur mr. Nat Metab. 2026 Jul;8(7):1528-1544. doi: 10.1038/s42255-026-01550-8. Epub 2026 Jun 23. Nat Metab. 2026. PMID: 42337138 Free PMC article.
Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models.
Roichman A, Reyes-Castellanos G, Chen Z, Chen Z, Mitchell SJ, MacArthur MR, Sawant A, Levett L, Powers JR, Burgo V, Gomez-Jenkins M, Ibrahim M, Xu X, Tomlinson B, Hang X, Pamer EG, Wei Y, Kang Y, White EP, Rabinowitz JD. Roichman A, et al. Among authors: macarthur mr. Cancer Res. 2025 Sep 2;85(17):3335-3347. doi: 10.1158/0008-5472.CAN-24-4378. Cancer Res. 2025. PMID: 40540354 Free PMC article.
Competitive catabolism drives hyperglycemia and hyperinsulinemia in obesity.
Weilandt DR, Lee WD, MacArthur MR, Liang L, Holman CD, Chu Q, Cowan AJ, Baur JA, Wingreen NS, Rabinowitz JD. Weilandt DR, et al. Among authors: macarthur mr. Cell Metab. 2026 Sep 1;38(9):1786-1801.e9. doi: 10.1016/j.cmet.2026.07.001. Epub 2026 Jul 21. Cell Metab. 2026. PMID: 42480542
60 results