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Page 1
Synthesis of C3/C1-Substituted Tetrahydroisoquinolines.
Mihoubi M, Micale N, Scala A, Jarraya RM, Bouaziz A, Schirmeister T, Risitano F, Piperno A, Grassi G. Mihoubi M, et al. Molecules. 2015 Aug 14;20(8):14902-14. doi: 10.3390/molecules200814902. Molecules. 2015. PMID: 26287146 Free PMC article.
A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada scoparia leaves against a panel of human and parasitic proteases revealed an interesting activity profile of 2 towards human 20S proteasome. This outcome suggests that the …
A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada scoparia leaves against a panel of huma …
Giant coronary artery aneurysm at autopsy.
Blackman A, Mohammed W. Blackman A, et al. BMJ Case Rep. 2018 Mar 20;2018:bcr2017222816. doi: 10.1136/bcr-2017-222816. BMJ Case Rep. 2018. PMID: 29559482 Free PMC article.
This case presents a woman in her early 20s who died after the sudden onset of chest pain. Five years earlier, she was investigated for a cardiac murmur during pregnancy and an echocardiogram revealed a 6.03.0 cm blood-filled sac compressing the left atrium and anterolater …
This case presents a woman in her early 20s who died after the sudden onset of chest pain. Five years earlier, she was investigated f …
Microfluidic protein isolation and sample preparation for high-resolution cryo-EM.
Schmidli C, Albiez S, Rima L, Righetto R, Mohammed I, Oliva P, Kovacik L, Stahlberg H, Braun T. Schmidli C, et al. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15007-15012. doi: 10.1073/pnas.1907214116. Epub 2019 Jul 10. Proc Natl Acad Sci U S A. 2019. PMID: 31292253 Free PMC article.
Less than 1 muL of cell lysate is required as starting material to solve the atomic structure of the untagged, endogenous human 20S proteasome. Our work paves the way for high-throughput structure determination of proteins from minimal amounts of cell lysate and opens more …
Less than 1 muL of cell lysate is required as starting material to solve the atomic structure of the untagged, endogenous human 20S p …
In silico identification of 20S proteasome-beta5 subunit inhibitors using structure-based virtual screening.
El Yaagoubi OM, Ezzemani W, Oularbi L, Samaki H, Aboudkhil S. El Yaagoubi OM, et al. J Biomol Struct Dyn. 2023 Jul 4:1-9. doi: 10.1080/07391102.2023.2232041. Online ahead of print. J Biomol Struct Dyn. 2023. PMID: 37403265
Proteasome inhibitors have effective anti-tumor activity in cell culture and can induce apoptosis by interfering with the degradation of cell cycle proteins. 20S Proteasome is acknowledged to be a satisfactory target that has persistent properties against the human immune …
Proteasome inhibitors have effective anti-tumor activity in cell culture and can induce apoptosis by interfering with the degradation of cel …
Detection of 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae in the United Kingdom, December 2021 to June 2022.
Day M, Pitt R, Mody N, Saunders J, Rai R, Nori A, Church H, Mensforth S, Corkin H, Jones J, Naicker P, Khan WM, Thomson Glover R, Mortimer K, Hylton C, Moss E, Pasvol TJ, Richardson A, Sun S, Woodford N, Mohammed H, Sinka K, Fifer H. Day M, et al. Euro Surveill. 2022 Nov;27(46):2200803. doi: 10.2807/1560-7917.ES.2022.27.46.2200803. Euro Surveill. 2022. PMID: 36398578 Free PMC article.
Most of these cases were associated with travel from the Asia-Pacific region; all were heterosexual people, with most in their 20s. Although all cases were successfully treated, not all partners of cases could be traced, and there is a risk of further transmission of ceftr …
Most of these cases were associated with travel from the Asia-Pacific region; all were heterosexual people, with most in their 20s. A …
The Major Stilbene Compound Accumulated in the Roots of a Resistant Variety of Phoenix dactylifera L. Activates Proteasome for a Path in Anti-Aging Strategy.
Benabbes R, Ouahhoud S, Moueqqit M, Addi M, Hano C, Delporte C, Nacoulma AP, Megalizzi V. Benabbes R, et al. Cells. 2022 Dec 23;12(1):71. doi: 10.3390/cells12010071. Cells. 2022. PMID: 36611864 Free PMC article.
Furthermore, the methanolic fraction of the TAAR-resistant date palm variety contains a significant product, determined by LC-MS/MS and 1H, 13C NMR, belonging to the family of hydroxystilbenes, which exhibits antioxidant capacities, inhibits the mushroom tyrosinase activity, and …
Furthermore, the methanolic fraction of the TAAR-resistant date palm variety contains a significant product, determined by LC-MS/MS and 1H, …
A fortuitous discovery of a neurofibroma in a female patient with type 1 neurofibromatosis: a case report.
Harrabi F, Methnani J, Houssem A, Abdelkader M, Mehdi BL, Amine SM, Mohamed BM, Ali BA. Harrabi F, et al. J Int Med Res. 2022 Dec;50(12):3000605221139716. doi: 10.1177/03000605221139716. J Int Med Res. 2022. PMID: 36510447 Free PMC article.
This congenital disease is characterized by a wide spectrum of clinical manifestations and degree of severity. This case report describes a female patient in her early 20s who presented with a complaint of lumbosciatica-like pain evolving for several months. ...
This congenital disease is characterized by a wide spectrum of clinical manifestations and degree of severity. This case report describes a …
STA9090 as a Potential Therapeutic Agent for Liver Fibrosis by Modulating the HSP90/TβRII/Proteasome Interplay: Novel Insights from In Vitro and In Vivo Investigations.
Mohammed OA, Abdel-Reheim MA, Alamri MMS, Alfaifi J, Adam MIE, Saleh LA, Farrag AA, Yahia AIO, Abdel-Ghany S, AlQahtani AAJ, Bahashwan E, Eltahir HB, Mohammed NA, El-Wakeel HS, Hazem SH, Saber S. Mohammed OA, et al. Pharmaceuticals (Basel). 2023 Jul 28;16(8):1080. doi: 10.3390/ph16081080. Pharmaceuticals (Basel). 2023. PMID: 37630994 Free PMC article.
Our findings suggest that STA9090-induced inhibition of HSP90 leads to the degradation of TbetaRII, a fibrogenic client protein of HSP90, through the activation of the 20S proteasomal degradation system. We also revealed that this degradation mechanism is not dependent on …
Our findings suggest that STA9090-induced inhibition of HSP90 leads to the degradation of TbetaRII, a fibrogenic client protein of HSP90, th …
Antiplasmodial potential of phytochemicals from Citrus aurantifolia peels: a comprehensive in vitro and in silico study.
Elmaidomy AH, Abdelmohsen UR, Sayed AM, Altemani FH, Algehainy NA, Soost D, Paululat T, Bringmann G, Mohamed EM. Elmaidomy AH, et al. BMC Chem. 2024 Mar 30;18(1):60. doi: 10.1186/s13065-024-01162-x. BMC Chem. 2024. PMID: 38555456 Free PMC article.
We found that limonin (2), luteolin (3), and myricetin (5) could interact with 20S a proteasome, choline kinase, and phosphocholine cytidylyltransferase, respectively, which are important enzymes for the survival and growth of the parasite. ...
We found that limonin (2), luteolin (3), and myricetin (5) could interact with 20S a proteasome, choline kinase, and phosphocholine c …
14 results